Interplay between thermal contact and hormonal activity: A kinetic analysis on smartphone-induced endocrine disruption [0.03%]
热接触与激素活性之间的相互作用：手机引起内分泌干扰的 kinetics 分析
Sunday Amos Onikanni,Nguyen Thi Ai Nhung,Omolola Esther Amos et al.
Sunday Amos Onikanni et al.
Endocrine toxicology has largely overlooked persistent, behavior-linked thermal microenvironments established by smartphones, a phenomenon characterized by near-continuous human-thermal interaction. In this review, we propose a mechanistic ...
The mechanism underlying PAK1-mediated regulation of estrogen secretion in Bactrian camels' granulosa cells via the steroid pathway [0.03%]
PAK1通过类固醇途径调节双峰骆驼颗粒细胞中雌激素分泌的机制研究
Qi Wang,Tingting Ge,Caihui Si et al.
Qi Wang et al.
This study investigates the regulatory role of p21-activated protein kinase 1 (PAK1) in estrogen secretion during ovulation induction in Bactrian camels, along with the associated molecular mechanisms. We evaluated the morphological differe...
β-sitosterol and next-generation neuroprotection for multi-target strategies and the gut-brain axis in neurodegenerative diseases [0.03%]
β-谷固醇与下一代神经保护在神经退行性疾病中的多靶点策略及脑肠轴研究
Azhagu Madhavan Sivalingam
Azhagu Madhavan Sivalingam
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases arise from complex interactions among oxidative stress, neuroinflammation, metabolic dysfunction, and dysregulated signaling networks. This review aim of the synthesiz...
The Microbiome-Gut-Gonad Axis: How Microbial Metabolites Orchestrate Reproductive Physiology, Pathology, and Therapy [0.03%]
微生物-肠道-生殖腺轴：微生物代谢产物如何协调生殖生理、病理和治疗
Amr Ali Mohamed Abdelgawwad El-Sehrawy,Ghaleb Oriquat,Jasur Rizaev et al.
Amr Ali Mohamed Abdelgawwad El-Sehrawy et al.
The human microbiome, a dynamic endocrine organ, exerts profound systemic influence through the production of bioactive metabolites. While the microbiome-gut-brain axis is well-established, the direct conduit between the gut microbiota and ...
L-arginine improves prenatal and pre-pubertal codeine-induced steroidogenesis deregulation by suppressing oxidative stress-dependent signaling in male wistar rats [0.03%]
L-精氨酸通过抑制雄性Wistar大鼠氧化应激依赖性信号改善阿片所致的胎盘和幼年肾上腺皮质类固醇激素生成异常
R E Akhigbe,O A Afolabi,A F Ajayi
R E Akhigbe
This study investigated the impact of prepubertal L-arginine on prepubertal and maternal codeine-induced testicular toxicity in F1 male offspring. Forty female rats were randomized at weaning into either vehicle-treated control or codeine-t...
Discovery of 17-imidazo[1,2-a]pyridinyl-3α-hydroxy-5α-androstanes (17IPAs) as novel potent positive allosteric modulators of the GABAA receptor: Synthesis, in vitro and in silico studies [0.03%]
发现17-咪唑并[1,2-a]吡啶基-3α-羟基-5α-雄甾烷（17IPAs）为新型强效GABAA受体正向变构调节剂：体内和计算机辅助研究
Yulia A Volkova,Valentina E Birukova,Sergey N Kolbaev et al.
Yulia A Volkova et al.
Neuroactive steroids (NASs) have attracted considerable interest as novel treatments for various central nervous system (CNS) disorders and as new intravenous general anesthetics. Herein, we report the synthesis, biological evaluation, and ...
Androgen receptor as therapeutic indicator for LAR-positive triple-negative breast cancer: Preclinical and clinical assessment [0.03%]
用于LAR阳性三阴性乳腺癌的治疗标志物——靶向雄激素受体的疗法：从临床前研究到临床试验评估
Nirali Shukla,Devanshi Sharma,Deepshikha Rathore et al.
Nirali Shukla et al.
Triple-negative breast cancer (TNBC) is an aggressive disease with limited treatment options, where the luminal androgen receptor (LAR+) subtype presents a promising target for AR-directed therapy. However, the impact of AR splice-variants ...
The 24,25(OH)2D3-TLCD3B signaling complex and reproductive function in mice and men [0.03%]
24,25(OH)₂D₃-TLCDB信号复合体在小鼠和人类生殖功能中的作用
Ireen Kooij,Katrine Mitrofanov,Anders Rehfeld et al.
Ireen Kooij et al.
Vitamin D influences male reproductive function, and the expression of the vitamin D-inactivating enzyme CYP24A1 in spermatozoa has consistently been shown to be positively correlated with semen quality. The predominant CYP24A1-generated me...
Testosterone and epitestosterone differentially regulate UDP-glucuronosyltransferases (UGT) activity [0.03%]
睾酮和表睾酮对糖基转移酶(UGT)活性的调节作用不同
Ling Xiao,Juan Qi,Yuanyuan Zhang et al.
Ling Xiao et al.
Despite being constantly exposed to endogenous substrates, the effects of these substrates on UDP-glucuronosyltransferase (UGT) activity remain poorly understood. This study investigated the effects of testosterone (T) and its 17-epimer epi...
Interferon-gamma-inducible protein-10 is associated to increased primary bile acids and fibrosis in primary sclerosing cholangitis [0.03%]
干扰素诱导蛋白-10与原发性硬化性胆管炎中主要胆酸增加和纤维化相关
Bettina Langhans,Leona Dold,Taotao Zhou et al.
Bettina Langhans et al.
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts. Altered bile acid (BA) profile was shown to trigger immune responses in the liver, contri...