Allele diversity of the killer cell immunoglobulin-like receptors KIR3DL1/S1 and the combination with their HLA ligands in Mexican Mestizos from Mexico City [0.03%]
墨西哥墨西哥城梅斯蒂索人中杀伤细胞免疫球蛋白样受体KIR3DL1 / S1的等位基因多态性及其与相应的HLA配体的组合研究
B A González-Quezada,M G J Sánchez-Fernández,A J Munguía-Saldaña et al.
B A González-Quezada et al.
Killer cell immunoglobulin-like receptors (KIRs), expressed on Natural Killer (NK) cells, activate/inhibit NK cell function through interactions with their HLA-A, B and C ligands. KIR3DL1 is one of the most polymorphic genes and its effect ...
Tukisa Smith,Charlotte Cunningham-Rundles
Tukisa Smith
Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody production due to either molecular defects intrinsic to B-cells or a failure of interaction between B-cells and T-cells. Patients typically have recurrent ...
Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population [0.03%]
人HLA-DRB1*13：02，HLA-DRB1 * 04：06和HLA-DQB1 * 06：04等位基因与韩国女性宫颈癌的关联研究
Hyoeun Shim,Boram Park,Hye-Jin Shin et al.
Hyoeun Shim et al.
Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cerv...
Genetic association between CD86 polymorphisms and the risk of sepsis in a Chinese Han population [0.03%]
汉族人CD86基因多态性与脓毒症易感性的遗传相关性研究
Yanjie Fu,Jinghua Zhang,Hansheng Bai et al.
Yanjie Fu et al.
Background: Sepsis is a clinical syndrome that is frequently observed after injury or infection, representing a leading cause of mortality worldwide. CD86 (B7-2) is a co-stimulatory molecule on antigen-presenting cells, a...
WITHDRAWN: Association of polymorphisms in CTLA4 and interleukin genes with Hashimoto's thyroiditis among Han Chinese: A case-control study [0.03%]
撤回：细胞毒性T淋巴细胞相关抗原4和白细胞介素基因多态性与汉族桥本甲状腺炎的相关性：一项病例对照研究
Xiaofei Lv,Xialian Tang,Jinbin Lai et al.
Xiaofei Lv et al.
Retraction of Publication
Human immunology. 2018 Oct 13:S0198-8859(18)30775-4. DOI:10.1016/j.humimm.2018.10.010 2018
The MHC in the era of next-generation sequencing: Implications for bridging structure with function [0.03%]
新一代测序时代的MHC：对连接结构与功能的启示
Effie W Petersdorf,Colm O&#x;hUigin
Effie W Petersdorf
The MHC continues to have the most disease-associations compared to other regions of the human genome, even in the genome-wide association study (GWAS) and single nucleotide polymorphism (SNP) era. Analysis of non-coding variation and their...
On the structure-function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking [0.03%]
关于MHCII类分子的结构功能以及单个氨基酸多态性如何改变其胞内转运机制的研究
Jacques Thibodeau,Mohamed Abdelwafi Moulefera,Renaud Balthazard
Jacques Thibodeau
Classical HLA class II molecules are highly polymorphic heterodimeric transmembrane proteins encoded by a polygenic cluster on chromosome 6. Polymorphic residues in the membrane-distal domains ensure that a large collection of microbial pep...
Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop [0.03%]
第17届人类白细胞抗原和免疫遗传学研讨会杀手细胞免疫球蛋白样受体(KIR)组报告摘要
Maneesh K Misra,Danillo G Augusto,Gonzalo Montero Martin et al.
Maneesh K Misra et al.
The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diver...
Improved accuracy of clinical HLA genotyping by next-generation DNA sequencing affects unrelated donor search results for hematopoietic stem cell transplantation [0.03%]
基于下一代测序的临床HLA基因分型准确性改进对造血干细胞移植无关供者检索结果的影响
Elizabeth S Allen,Bing Yang,Jodi Garrett et al.
Elizabeth S Allen et al.
Matching of human leukocyte antigen (HLA) genes is critically important in hematopoietic stem cell transplantation (HSCT). HLA genes are highly polymorphic and HLA matching has historically been limited by technologies that are unable to un...
IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases [0.03%]
IL-35促进B细胞STAT3磷酸化和IL-10的产生，但冠状动脉疾病患者B细胞中IL-35的分泌减少
Zhendong Zhu,Yunmei Zhang,Jiyun Ye et al.
Zhendong Zhu et al.
Interleukin (IL)-35 is a heterodimeric cytokine composed of the IL-12A subunit and the Epstein-Barr virus induced gene 3 (EBI3) subunit. Binding of IL-35 with IL-12 receptor subunit beta 2 (IL-12RB2) and IL-6 signal transducer (IL-6ST) occu...