Cytotoxic and immunomodulatory activity of CD151-LEL-based peptides in breast cancer and THP-1 cells [0.03%]
基于CD151-LEL的肽段对乳腺癌及THP-1细胞的细胞毒作用和免疫调节作用
Rahul Kumar Vempati,RamaRao Malla
Rahul Kumar Vempati
CD151, a cell surface oncoprotein belongs to the tetraspanin family, drives metastasis, drug resistance, and immune escape, and is recognized as a tumor-associated antigen (TAA). In the screening phase, a positive correlation between CD151 ...
A multipronged Tα1 reset of CD8+ T cell cytotoxicity against breast cancer [0.03%]
重编程CD8⁺T细胞细胞毒性的多重手段对抗乳腺癌
Smriti Mishra,Gaurang Telang,Anurag Sureshbabu et al.
Smriti Mishra et al.
Thymosin α1 (Tα1) is an endogenous thymic peptide that enhances immune competence through activation of T cells, dendritic cells, and innate immune pathways. However, its direct impact on CD8+ T cell-mediated antitumor immunity in breast ...
Gene alterations in inborn errors of immunity and their presence in cancers: implications for oncogenesis, progression, and outcomes [0.03%]
基因组改变在先天性免疫缺陷疾病中的作用及其在癌症中的存在意义：对肿瘤发生、发展和预后的启示
Samuel Lokanc,Patrick Sipila,Geoffrey D E Cuvelier et al.
Samuel Lokanc et al.
Inborn Errors of Immunity (IEI) are genetic disorders impairing the immune system, increasing susceptibility to infections, autoimmunity, inflammation, and malignancies. Mutations in over 500 genes have been shown to cause IEI. This study i...
Meta-analysis of the association between HLA-G 14-bp Insertion/Deletion polymorphism and susceptibility to viral infections and cancer risk [0.03%]
HLA-G 14 bp插入/缺失多态性与病毒感染易感性和癌症风险相关性的 meta 分析研究
Hager Bourogâa,Sabrine Dhouioui,Haifa Zaibi et al.
Hager Bourogâa et al.
Background/objective: HLA-G 14-bp insertion/deletion (I/D) polymorphism has been linked to both cancer susceptibility and various viral infections. This meta-analysis examined the relationship between HLA-G 14-bp I/D poly...
Modulatory effect of magnesium sulfate on NLRP3 inflammasome expression by human monocytes stimulated in vitro with monosodium urate [0.03%]
硫酸镁通过体外刺激的尿酸单钠盐对人体单核细胞NLRP3炎性小体表达的调节作用
Gabriela de Oliveira Franco,Mariana Romao-Veiga,Vanessa Rocha Ribeiro-Vasques et al.
Gabriela de Oliveira Franco et al.
The NLRP3 inflammasome contributes to inflammation in preeclampsia (PE), a hypertensive pregnancy disorder associated with immune imbalance. Magnesium sulfate (MgSO4), the standard therapy for eclampsia, also exhibits anti-inflammatory prop...
ILT4 and its R20H variant as marker of poor prognosis in Spanish patients with colorectal cancer [0.03%]
西班牙结直肠癌患者中ILT4及其R20H变异体作为预后不良标志物的研究
Sandra Fernández-Uría,Christian Vaquero-Yuste,Elena Álvarez-González et al.
Sandra Fernández-Uría et al.
Background: Immune checkpoint blockade is proving beneficial for cancer treatment by stimulating the anti-tumor immune response. However, the lack of success in certain cancer types encourages the research of new potentia...
Characterization of anti-HLA antibodies pre- and post-renal transplantation in the Tunisian central region [0.03%]
Maha Changuel,Ichrak Bannour,Mourad Elghali et al.
Maha Changuel et al.
Background: In kidney transplantation, anti-HLA antibodies are associated with poor graft outcomes. This study aimed to describe the profile of anti-HLA antibodies in both renal transplanted patients and patients awaiting...
Nathan A Lemp,Peter Lalli,Sara O Dionne
Nathan A Lemp
Background: Human leukocyte antigen (HLA) typing is essential for organ donor-recipient matching. However, complexities arise when donors have unique clinical histories that are not fully disclosed to laboratory personnel...
A novel pathogenic RFXANK variant causing MHC class II deficiency in two unrelated patients from Mexico [0.03%]
墨西哥两个无关患者的MHCⅡ类分子缺陷的一种新型致病性RFXANK变异
Maria Enriqueta Nuñez-Nuñez,Lucero Valenzuela-Vazquez,Juan Carlos Bustamante-Ogando et al.
Maria Enriqueta Nuñez-Nuñez et al.
Association of NLRC3 gene polymorphism with Graves' disease susceptibility in a Southwest Chinese Han population [0.03%]
NLRC3基因多态性与我国西南地区汉族人群Graves病易感性的关联研究
Zhongzhi Liang,Qinxingzi Li,Xin Wang et al.
Zhongzhi Liang et al.
Purpose: Graves' disease (GD) is a frequently-occurring autoimmune thyroid 3condition, distinguished by complex molecular and cellular alterations. However, the fundamental mechanisms underlying its pathogenesis are still...