Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers [0.03%]
单细胞转录组揭示SOCE阻断剂对炎性谱系的靶向调节作用
Andreas Stephanou,Madhav Mantri,Divya Shankaranarayanan et al.
Andreas Stephanou et al.
Store-operated calcium entry (SOCE) plays a critical role in regulating intracellular calcium signaling and is essential for immune cell functions. SOCE blockade with the pyrazole derivative BTP2 has been explored as an anti-inflammatory st...
Prevalence and dynamics of HLA Donor-Specific antibodies in Simultaneous Liver-Kidney transplantation [0.03%]
肝肾联合移植中HLA供者特异性抗体的流行率及动态变化规律
Qiuheng Zhang,Mario A Pulido,Sofia Soltero et al.
Qiuheng Zhang et al.
Aims: Donor-specific antibodies (DSAs) negatively affect outcomes in solid organ transplantation outcomes, but their significance in simultaneous liver-kidney (SLK) transplant recipients remains incompletely understood. T...
The role of complement protein and complement regulatory protein in diabetic nephropathy [0.03%]
补体蛋白和补体调节蛋白在糖尿病肾病中的作用
Xiaoxiang Jiang,Zhanzhan Sun
Xiaoxiang Jiang
Background: Diabetic nephropathy is one of the main causes of end-stage renal disease, with dysregulation of the complement system playing a critical role in its pathogenesis. However, the specific mechanisms, key effecto...
A wide proteome analysis to engineer an efficient epitope based vaccine against Salmonella Typhi: An immunoinformatic study [0.03%]
一种有效的针对伤寒沙门氏菌的基于表位的疫苗的蛋白质工程免疫信息学研究
Mahsa Beiranvand,Nemat Shams,Amin Jaydari et al.
Mahsa Beiranvand et al.
Background: Typhoid fever, a potentially fatal disease caused by Salmonella enterica serovar Typhi, requires effective vaccines. This study aimed to design a recombinant subunit vaccine using the most immunogenic proteins...
Preclinical and Clinical Developments in Treg Therapy for Heart Transplantation: Critical Assessment and Translational Challenges [0.03%]
心脏移植中Treg治疗的临床前和临床发展：批判性评估与转化挑战
Konstantinos Mengrelis,Laurenz Wolner,Rayna Lellis Lakatos et al.
Konstantinos Mengrelis et al.
Regulatory T cells (Tregs) represent a promising approach to induce donor-specific tolerance in cardiac transplantation, potentially reducing reliance on chronic immunosuppression. This review critically evaluates preclinical and clinical e...
Unique case of False-Positive pan-HLA-A antibody detection in LABScreen single antigen bead assay [0.03%]
LABScreen单抗原微珠试验中假阳性全HLA-A抗体检测的特殊病例
Merschman Jarret,Barnes Rachel,Burmeister Lydia et al.
Merschman Jarret et al.
Accurate detection of HLA antibodies is essential for assessing immunologic risk in transplantation. Solid-phase antibody assays (SPA), particularly Luminex-based single-antigen bead (SAB) assay offer high sensitivity, but are prone to fals...
HLA-G alleles in Italian patients with locally advanced rectal cancer (LARC) [0.03%]
意大利局部晚期直肠癌(LARC)患者的HLA-G基因型分析
Lucia Scarabel,Erick C Castelli,Michela Zorzi et al.
Lucia Scarabel et al.
Aim: High-resolution HLA-G typing in selected patients with locally advanced rectal cancer (LARC) enrolled at the National Cancer Institute "Centro di Riferimento Oncologico di Aviano (CRO) IRCCS" (Italy) (CRO-2023-77). ...
The limited clinical utility of Neutrophil-to-Lymphocyte ratio in systemic lupus Erythematosus: A Meta-Analysis with external validation [0.03%]
外验证缺血性及出血性卒中患者颈动脉内膜切除术的疗效：系统评价和Meta分析
Jingxue Du,Xiangping Tu,Manrong He et al.
Jingxue Du et al.
Objective: To evaluate the diagnostic and discriminative value of the neutrophil-to-lymphocyte ratio (NLR) in systemic lupus erythematosus (SLE). Methods:...
Novel association of HLA-DQA1 and HLA-DPB1 alleles with Acute myeloid leukemia susceptibility in (Central Asian) Kazakhstani Population: A Case-Control study [0.03%]
哈萨克族急性髓系白血病易感性的HLA-DQA1和HLA-DPB1新关联：一项基于病例对照的研究
Aida Turganbekova,Zhandos Burkitbayev,Zhulduz Zhanzakova et al.
Aida Turganbekova et al.
Background: Acute myeloid leukemia (AML) is a diverse hematological cancer characterized by clonal growth of myeloid precursors in the bone marrow. Although the core genetic pathways involved in AML development are not co...
HLA typing of HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 loci of 226 individuals from three metropolitan areas in South Africa [0.03%]
南非三个主要城市226人的HLA-A、-B、-C、-DPB1、-DQB1和-DRB1位点分型检测结果
Akiko Suzuki,Richard Baguma,Shobna Sawry et al.
Akiko Suzuki et al.
The aim of this study was to characterize HLA diversity in individuals from clinical research sites in order to better understand T cell responses to COVID-19 vaccines in relation to their HLA profiles. Next-generation sequence-based typing...