Association of IL4 and IL17A genetic polymorphisms with COVID-19 severity in a southern Brazilian population [0.03%]
巴西南部人群中IL4和IL17A基因多态性与COVID-19严重程度的关系
Manuela Nunes Drehmer,Gabriel Vaisam Castro,Daniele Delacanal Lazzari et al.
Manuela Nunes Drehmer et al.
COVID-19 has demonstrated marked differences in clinical manifestations and outcomes, with severe cases presenting excessive inflammatory responses known as cytokine storms. Polymorphisms in cytokine genes, such as interleukin-4 (IL4) and i...
Susceptibility associations of HLA class II gene polymorphisms in oral submucous fibrosis derived oral squamous cell carcinoma [0.03%]
口腔黏膜纤维化来源的口腔鳞状细胞癌中HLA-II类基因多态性的易感性关联分析
Yisi Tan,Yao Xiao,Xiaoqin Huang et al.
Yisi Tan et al.
Objective: This study aimed to explore associations between human leukocyte antigen (HLA) class II (DRB1, DQB1, DPB1) alleles and haplotypes and susceptibility to oral submucous fibrosis (OSF) and its progression to oral ...
Roles of full-length and Δα1 HLA-G isoforms in NK-cell regulation and vascular SARS-CoV-2 infection [0.03%]
全长和Δα1 HLA-G等位基因在NK细胞调节和血管SARS-CoV-2感染中的作用
G Schiuma,D Tronik-Le Roux,S Beltrami et al.
G Schiuma et al.
Human Leukocyte Antigen-G (HLA-G) is a key immunomodulatory molecule with multiple isoforms, including recently identified variants lacking the α1 domain (HLA-G Δα1). The absence of the α1 domain may reduce immune inhibition, particular...
Impact of NQO1, GSTM1 and GSTT1 genetic variants on susceptibility and relapse in childhood acute lymphoblastic leukemia [0.03%]
NQO1、GSTM1和GSTT1基因多态性对儿童急性淋巴细胞白血病易感性和复发的影响
Nathália de Sousa Pereira,Thiago Cezar Fujita,Carlos Eduardo Coral de Oliveira et al.
Nathália de Sousa Pereira et al.
Acute lymphoblastic leukemia (ALL) is a multifactorial malignancy influenced by genetic and environmental factors. Polymorphisms in detoxification enzymes such as NQO1, GSTM1, and GSTT1 may modulate susceptibility and treatment response. Th...
Identification of HLA-DR linear antibody epitopes in transplant patient sera using a multiplexed peptide immunoassay [0.03%]
利用多联肽免疫检测法定量移植患者血清中HLA-DR线性抗体表位
Maahi Ameer,Dhruvi K Mehta,Gregory S Cohen et al.
Maahi Ameer et al.
Molecular mismatch analysis is increasingly used to assess donor-recipient compatibility in transplantation. We sought to determine if reactivity against continuous HLA-DR epitopes could be directly measured using a peptide-based immunoassa...
Immunological Functions of Th17 cells in Colon Cancer: From Pathogenic Mechanisms to Emerging Treatments [0.03%]
Th17细胞在结肠癌免疫功能中的作用：从致病机制到新兴治疗措施
Qamar Abuhassan,Ali M Atoom,M M Rekha et al.
Qamar Abuhassan et al.
Colon cancer (CC) constitutes a significant global health challenge, characterized by increasing incidence and mortality rates that underscore the necessity for continued investigative efforts. Inflammation-driven cellular and molecular pro...
Revisiting HLA-G in solid organ Transplantation: Mechanistic insights and translational advances [0.03%]
组织移植中重新审视HLA-G：机制见解和转化进展
Ashwin Ajith,Laura L Mulloy,Imran Gani et al.
Ashwin Ajith et al.
Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule with potent immunoregulatory functions that plays a central role in promoting allograft acceptance. Unlike classical HLA molecules, HLA-G displays limited polymorphis...
Imputing HLA-G high-resolution alleles and regulatory haplotypes from exomes and SNP array data [0.03%]
从外显子组和SNP阵列数据中估算HLA-G高分辨率等位基因和调控型染色体片段
Rafaela Miranda Barbosa,Nayane Dos Santos Brito Silva,Diogo Meyer et al.
Rafaela Miranda Barbosa et al.
HLA-G encodes an immune checkpoint molecule with restricted expression in immune-privileged tissues and pathological conditions. It exhibits limited coding diversity but substantial regulatory-region variation influencing expression levels....
The immunosuppressive role of HLA-G+ extracellular vesicles in bone marrow of infiltrating tumors: The lesson learned from neuroblastoma and multiple myeloma [0.03%]
骨髓肿瘤浸润中HLA-G+胞外囊泡的免疫抑制作用：从神经母细胞瘤和多发性骨髓瘤得到的经验教训
Irma Airoldi,Debora Soncini,Danilo Marimpietri et al.
Irma Airoldi et al.
It is now clearly established that extracellular vesicles (EV)s represent important players in the regulation of bone marrow (BM) microenvironment during cancer progression, and anti-tumor responses. Indeed, healthy cells and neoplastic cel...