HLA DRB1*01:02 allele is associated with anti-AT1R antibodies production in kidney transplanted patients [0.03%]
HLA-DRB1*01:02等位基因与肾移植患者的抗AT1R抗体产生有关
Ilaria Carelli,Alessandro Romano,Angelo Corso Faini et al.
Ilaria Carelli et al.
Background: Kidney transplantation is lifesaving treatment for end-stage renal disease, yet immune-mediated complications limit long-term graft survival. Non-HLA antibodies (NHLA), particularly anti-Angiotensin type 1 rec...
Innovative multi-epitope vaccine development for rheumatoid arthritis via immunoinformatics [0.03%]
基于免疫信息学的类风湿关节炎多抗原表位疫苗创新设计与开发研究进展
Azizeh ShadiDizaji,Farideh Ghalamfarsa,Kagan Tolga Cinisli et al.
Azizeh ShadiDizaji et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent joint inflammation, pain, and progressive disability, affecting millions worldwide. Current therapies, including anti-inflammatory and immunosuppressive agents,...
Activating KIR3DS1: A key Driver of KIR3DL1/HLA-Bw4-Linked risk in CML [0.03%]
激活KIR3DS1基因：CML中KIR3DL1/HLA-Bw4连锁风险的关键驱动因素
Masoumeh Basirat,Maral Mokhtari,Hassan Ghader Abadi et al.
Masoumeh Basirat et al.
Background: Killer-cell immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cell development and operate by interacting with their cognate ligands, human leukocyte antigen class I (HLA-I) molecules. KIR and ...
Lindsey C Wlosinski,Michael A Scott,Cynthia A Lucidi et al.
Lindsey C Wlosinski et al.
Background: Transplant patients may have circulating non-ABO red blood cell (RBC) antibodies, but the influence of RBC alloimmunization on solid-organ transplantation outside of the ABO blood group system is not well know...
In silico design of a VacA-Based Multi-Epitope subunit vaccine candidate for immunoprotection against Helicobacter pylori [0.03%]
基于VacA的多表位亚单位疫苗候选设计用于抗幽门螺旋杆菌免疫防护
Sree Kathyayani Sundara Raman,Prayukta Padelkar,Gnanaprakash Jeyaraj et al.
Sree Kathyayani Sundara Raman et al.
Helicobacter pylori, a globally prevalent gastric pathogen associated with gastric carcinoma, ulcers of the bowel, and persistent gastritis where the vacuolating cytotoxin A (vacA), a major virulence factor, that promotes cellular damage an...
PD-1 high expression in T lymphocytes correlates with decreased survival in childhood B-cell precursor acute lymphoblastic leukemia [0.03%]
儿童前体B细胞急性淋巴细胞白血病中T淋巴细胞PD-1高表达与生存率下降相关
Clara de Oliveira Andrade,Chaislan Igor da Silva Nascimento,Jose Carlos Aragao-Santos et al.
Clara de Oliveira Andrade et al.
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common in pediatric malignancy. Despite high cure rates, relapse and treatment resistance remain major causes of mortality. Immune checkpoint molecules such as programmed d...
Shared genetic architecture between major depressive disorder and inflammatory bowel disease: Insights from large-scale genome-wide cross-trait analysis [0.03%]
重大抑郁障碍和炎症性肠病之间共享的遗传结构：来自大规模组间交叉性状分析的新视角
Yifan Ding,Qinghua Luo,Xiaojun Yan et al.
Yifan Ding et al.
Background: Major depressive disorder (MDD) and inflammatory bowel disease (IBD) exhibit clinical associations, yet the cross-disease genetic links and shared mechanisms between them remain unclear. This study aims to exp...
CAR-NK cell therapy for overcoming antigen heterogeneity and immunosuppressive tumor microenvironments [0.03%]
CAR-NK细胞疗法克服抗原异质性和免疫抑制性肿瘤微环境
Mohammad Qutub,Tanvi Premchandani,Sakshi Bhagat et al.
Mohammad Qutub et al.
Chimeric antigen receptor engineered natural killer cells (CAR-NK) have emerged as a transformative strategy in cancer immunotherapy, offering MHC-independent cytotoxicity, reduced graft-versus-host disease risks, and allogeneic "off-the-sh...
Bone marrow and peripheral blood HLA-G in hematologic diseases presenting with impaired erythropoiesis [0.03%]
骨髓和外周血HLA-G与红细胞生成受损的血液病的关系
Bruna Carvalho,Lorena Lobo de Figueriedo-Pontes,Priscila Santos Scheucher et al.
Bruna Carvalho et al.
The HLA-G molecule is expressed in few tissues and cells, such as erythroid precursors, in which it has been associated with cell signaling, maturation, and proliferation. Considering that the daily production of erythrocytes is massive, th...
Reverse vaccinology and immunoinformatics Approaches Driven designing of a Novel Multi-Epitope mRNA vaccine against Toxoplasma gondii [0.03%]
反向 vaccinology 和免疫 informatic 方法驱动的新型多表位 mRNA 疫苗的设计，用于对抗 Toxoplasma gondii
Noimul Hasan Siddiquee,Md Abdullah Al Mamun,Tasnuva Islam Dremit et al.
Noimul Hasan Siddiquee et al.
Toxoplasmosis is a zoonotic infectious disease caused by the intracellular apicomplexan parasite Toxoplasma gondii and primarily affects warm-blooded animals. Despite its global spread, the disease has limited therapeutic interventions. Che...