Assay-dependent discordance in detecting a rare HLA-DPB1 allele: long-range PCR vs. hybrid capture NGS [0.03%]
基于长片段PCR和杂交捕获NGS检测HLA-DPB1罕见等位基因的分歧现象
Katie Rozar,Pedro Cano,Deepak Verma et al.
Katie Rozar et al.
Next-generation sequencing (NGS) has become fundamental to high-resolution HLA typing, but methodological differences between long-range PCR (LR PCR) and hybrid capture (HC) approaches can lead to discrepant results. This study examined cas...
Reduced socs2 expression and elevated IL-4/IL-23 levels in multiple sclerosis patients: Implications for immune dysregulation [0.03%]
多发性硬化患者Socs2表达下降和IL-4/IL-23水平升高：对免疫功能失调的意义
Virginia Sedeño Monge,Gerardo Santos López,Elizabeth Bautista Rodríguez et al.
Virginia Sedeño Monge et al.
Multiple sclerosis (MS) is an autoimmune, chronic, and demyelinating disease of the central nervous system. Dysregulated cytokine signaling, particularly through the suppressor of cytokine signaling (SOCS) family, is implicated in MS pathog...
Rare variants in inborn errors of immunity genes in young adults with severe COVID-19: Insights from a Brazilian cohort [0.03%]
巴西队列中先天性免疫缺陷基因的罕见变异与年轻人中的重症新冠肺炎：来自巴西队列的研究发现
Marcus Villander Barros de Oliveira Sá,Gabriela Dias Rocha,Pablo Rafael Silveira Oliveira et al.
Marcus Villander Barros de Oliveira Sá et al.
Background: Host genetic variability, particularly involving inborn errors of immunity (IEI), has emerged as a critical determinant of interindividual differences in COVID-19 severity, yet comprehensive genomic characteri...
Xiaoxiang Jiang,Xuequn Miao
Xiaoxiang Jiang
Background: Dysregulation of the renal immune microenvironment contributes to kidney pathology and also exerts widespread effects on multiple systems, including the intestinal, respiratory, cardiovascular, and nervous sys...
Genetic associations between asthma and type 2 inflammatory Diseases: Insights from pleiotropic loci and genes: Shared Genetics of Type 2 Inflammatory Diseases [0.03%]
哮喘和2型炎症性疾病之间的基因关联：多效性位点和基因的启示：2型炎症性疾病共有的遗传学
Xing-Ru Chen,Chun-Tao Liu
Xing-Ru Chen
Background: Type 2 inflammatory diseases (T2IDs) often coexist, but their shared genetic basis remains unclear. This study explores common genetic basis between asthma and other T2IDs and identifies pleiotropic loci and m...
Abigail Joseph,Helen H Mah,Sunitha Vege et al.
Abigail Joseph et al.
Background: ABO histocompatibility plays a critical role in red blood cell (RBC) transfusions and is of great importance in solid organ and hematopoietic stem cell transplantation. ABO is primarily typed from red blood ce...
From Discovery to precision Tolerance: Re-Imagining Patient-Matched regulatory T cells in Shaping of a roadmap for personalized immune Re-Balancing [0.03%]
从发现到精准耐受：重塑个性化免疫再平衡的患者匹配型调节性T细胞路线图
Saleem Ahmad,Muhammad Nauman Aftab,Muhammad Shahbaz Aslam
Saleem Ahmad
The recognition of FOXP3 as the master regulator of regulatory T cells (Tregs) established the genetic and functional basis for peripheral immune tolerance. Contemporary advances in single-cell genomics and epigenetic mapping have further r...
The paradigm shift of virtual crossmatch for deceased donor kidney allocation in the United States, 2015 - 2024 [0.03%]
美国2015年至2024年死体肾脏分配中的虚拟交叉配型范式转换
Thomas G Dolan,Kelley M K Hitchman,John G Lunz et al.
Thomas G Dolan et al.
Background: Virtual Crossmatch (VXM) analysis, a specialized evaluation of immunologic compatibility based on patient anti-HLA antibody testing and donor HLA genotyping, is an invaluable tool in organ transplantation. Whi...
Transplant of serologic A1 but genotype A2 kidneys to ABO O and B recipients is Feasible and safe [0.03%]
A1血型但基因类型为A2的肾脏移植给O和B型血的受者是可行且安全的
Nassir M Thalji,Matthias Kapturczak,Tamer Shaker et al.
Nassir M Thalji et al.
Background: Kidney transplants from ABO A2 donors to O and B recipients reduce wait times without compromising outcomes. Recent work shows that ABO genotyping more accurately identifies A2 donors than serologic methods. H...
Exploring the shared genetic architecture of migraine and autoimmune diseases [0.03%]
探究偏头痛和自身免疫性疾病共有的遗传结构
Jun Chen,Yamei Wu,Meijun Liu et al.
Jun Chen et al.
Background: Migraine (MIG) frequently co-occurs with autoimmune diseases (ADs), but the shared genetic basis underlying this comorbidity remains unclear. ...