Conserved epitope-driven in silico design of a multi-epitope vaccine against the tick-borne wetland virus [0.03%]
基于保守表位的湿地病毒多表位疫苗的计算机设计
Kadhirmathiyan Velumani,Sarumathi Umapathi,Balamurugan Shanmugaraj
Kadhirmathiyan Velumani
Background: The tick-borne viruses are primarily transmitted through the bites of infected ticks. Wetland virus (WELV) is a newly identified tick-borne pathogen with no licensed vaccines and limited preventive strategies....
The significance of galectin-9 and T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) in patients with chronic lymphocytic leukemia: The role of immune evasion [0.03%]
糖类配基受体galectin-9和T细胞免疫球蛋白及粘膜素结构域分子-3(TIM-3)在慢性淋巴细胞性白血病患者中的意义：免疫逃逸的作用
Samia Hussein,Ezzat Moustafa Mohamed,Hoda F Ebian et al.
Samia Hussein et al.
Background: Chronic lymphocytic leukemia (CLL) is a hematological malignancy with the accumulation of mature, monoclonal B lymphocytes. CLL cells can escape the host's immune response by inducing T-cell exhaustion. This o...
The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks [0.03%]
人类白细胞抗原在脐带血衍生的高级细胞治疗发展中的功能相关性：公共脐带血库的新方向
Panagiotis Mallis,Theofanis Chatzistamatiou,Alexandra Siorenta et al.
Panagiotis Mallis et al.
CBUs have been applied as alternative source of HSCs transplantation. The increasing preference for haploidentical HSC transplantation has resulted in a reduced application of CBUs worldwide. Banked CBUs in public CBBs have been processed w...
From educational to graded: redefining proficiency testing in ABO genotyping [0.03%]
从教育性到等级制：ABO基因分型能力测试的再定义
Reut Hod-Dvorai,Cathi Murphey,Valia Bravo-Egana et al.
Reut Hod-Dvorai et al.
Aim: ABO genotyping is a valuable tool when serologic typing is inconclusive or not feasible. This study evaluated whether ABO genotyping delivers the same high accuracy and inter-laboratory consistency as serologic metho...
Recurrent spontaneous abortion: integrated bioinformatics and histological validation identify FURIN and NEDD4 as ferroptosis-associated endometrial markers [0.03%]
复发性自然流产：整合生物信息学和组织病理学验证鉴定FURIN 和NEDD4 为与内膜铁死亡相关的标志物
Xia Han,Ye-Ye Feng,Lu Wang
Xia Han
Background: Unexplained recurrent spontaneous abortion (RSA) affects 1-2% of couples and lacks reliable molecular markers. Emerging evidence links ferroptosis-a form of iron- and lipid-peroxide-driven cell death-to impair...
H Kahlyar,C Hogan,D Roxby et al.
H Kahlyar et al.
ABO blood group compatibility is a critical factor in solid organ and haemopoietic stem cell transplantation. In ABO-incompatible (ABOi) transplantation, recipient anti-A and/or anti-B antibodies may bind to donor red cell or endothelial A ...
Classical HLA allele and haplotype frequency estimates in US populations [0.03%]
美国各人群中经典的HLA等位基因和单体型频率估算
Loren Gragert,Abeer Madbouly,Pradeep Bashyal et al.
Loren Gragert et al.
The human leukocyte antigen (HLA) system is the primary determinant of donor selection in allogeneic hematopoietic cell transplantation (HCT) and plays a central role in solid organ transplantation, immune-mediated disease studies, evolutio...
John Mukisa,Samuel Kyobe,Marion Amujal et al.
John Mukisa et al.
Killer-cell immunoglobulin-like receptors (KIRs) are critical regulators of the innate immune system and are found on the surfaces of natural killer (NK) cells. The KIR encoding genes, located on chromosome 19q13.4, are genetically diverse ...
Low levels of soluble HLA-G as an immunological feature associated with type 2 diabetes mellitus and its microvascular complications [0.03%]
可溶型HLA-G低水平与2型糖尿病及其微血管并发症相关联的一项免疫学特征
Noorulhuda F Khalaf,Isam N Salman,Ali H Ad&#x;hiah et al.
Noorulhuda F Khalaf et al.
Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation, and soluble HLA-G (sHLA) molecules are effective immunomodulators in controlling inflammation. However, sHLA-G role in T2DM pathogenesis and its microvascul...
Investigation of human leukocyte antigen alleles as risk factors for cryptococcal disease in Ugandan individuals with HIV [0.03%]
人白细胞抗原基因型与乌干达HIV感染者隐球菌病的相关性研究
Caleb P Skipper,Biyue Dai,Bruno Borges et al.
Caleb P Skipper et al.
Cryptococcus neoformans is an opportunistic fungal infection and a leading cause of HIV-associated meningitis, contributing significantly to AIDS-related mortality, especially in Africa. Despite advancements in treatment, case fatality rate...