Study of Colombia North Wiwa El Encanto Amerindians HLA- genes: Pacific Islanders relatedness [0.03%]
哥伦比亚北部威瓦埃恩卡托美洲原住民HLA基因的研究：与太平洋岛民的亲缘关系
Antonio Arnaiz-Villena,Jose Palacio-Grüber,Ignacio Juarez et al.
Antonio Arnaiz-Villena et al.
We have studied Wiwa/Sanja Amerindians HLA-A, -B, -C, -DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from "El Encanto" town at Guanachaca riverside. High frequency alleles were in general present in ot...
CCR5Δ32 - A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility [0.03%]
CCR5Δ32-多重硬化炎性反应中的保护因素拼图的一块
Lian Lopes Troncoso,Alessandra Pontillo,Enedina Maria Lobato de Oliveira et al.
Lian Lopes Troncoso et al.
Background: Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migra...
Divya Sai Katikaneni,Lei Jin
Divya Sai Katikaneni
MHC class II regulates B cell activation, proliferation, and differentiation during cognate B cell-T cell interaction. This is, in part, due to the MHC class II signaling in B cells. Activation of MHC Class II in human B cells or "primed" m...
Genetic screening of male patients with primary hypogammaglobulinemia can guide diagnosis and clinical management [0.03%]
男性原发性低丙球血症患者基因筛查可指导诊断及临床治疗
Nicolas Vince,Gaël Mouillot,Marion Malphettes et al.
Nicolas Vince et al.
The precise diagnosis of an immunodeficiency is sometimes difficult to assess, especially due to the large spectrum of phenotypic variation reported among patients. Common variable immunodeficiency disorders (CVID) do not have, for a large ...
Continue to focus clinical decision-making on the antigen recognition domain for the present [0.03%]
继续聚焦于抗原识别域的临床决策
Carolyn Katovich Hurley,Jennifer Ng
Carolyn Katovich Hurley
Next generation DNA sequencing has facilitated the routine characterization of complete HLA gene sequences. These data complement structural and functional studies of HLA elements encoded outside of the exons specifying the antigen recognit...
No association of IL2, IL4, IL6, TNF, and IFNG gene polymorphisms was found with Taenia solium human infection or neurocysticercosis severity in a family-based study [0.03%]
一项基于家庭的研究未发现白细胞介素-2，白细胞介素-4，白细胞介素-6，肿瘤坏死因子及干扰素-γ基因多态性与猪囊尾蚴感染或脑囊尾蚴病严重程度有关联
A Fleury,C Alaez,A Dessein et al.
A Fleury et al.
Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While t...
HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians [0.03%]
挪威4514名健康人的HLA-A、-C、-B、-DRB1、-DQB1和-DPB1等位基因及单倍型的频率分布
Asgeir Lande,Irene Andersen,Torstein Egeland et al.
Asgeir Lande et al.
We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on ...
Limited impact of pre-existing donor specific HLA-antibodies (DSA) on long term allograft survival after first adult liver transplantation [0.03%]
供者特异性HLA抗体(DSA)对首次成人肝脏移植术后长期移植物存活的有限影响
Martina Koch,Matthias Marget,Martina Sterneck et al.
Martina Koch et al.
The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific ant...
Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong's experience [0.03%]
模拟非遗传性母系抗原接受HLA不符的脐带血以增加匹配单位的机会：香港的经验
Janette Kwok,Mengbiao Guo,Wanling Yang et al.
Janette Kwok et al.
In Cord blood transplantation (CBT), the non-inherited maternal antigen (NIMA) virtual six HLA matched CB is found to have similar outcomes to six HLA inherited matched CB. Such virtual HLA matched CB units can be generated by substituting ...
Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes? [0.03%]
在进行allo-HSCT的10/10 HLA匹配无关供受者对中，MHC γ区SNPs的匹配能否改善预后？
Ann M Moyer,Shahrukh K Hashmi,Cynthia Kroning et al.
Ann M Moyer et al.
Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching...