Y Yin,F Prewitt,J Nguyen et al.
Y Yin et al.
Reuse of a previously transplanted solid organ for another recipient prevents waste of functioning organs. Here, we present a case of a kidney transplant in which the donor had previously received a kidney from a living donor 6 years earlie...
In-silico design of a therapeutic multi-epitope peptide candidate vaccine against rheumatoid arthritis [0.03%]
一种治疗类风湿性关节炎的多表位肽候选疫苗的计算机设计方法
Azadeh Mohammadi Sepahvand,Nasrin Azarbani,Fateme Zare et al.
Azadeh Mohammadi Sepahvand et al.
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting the joints, resulting in inflammation, swelling, and pain, ultimately impacting patients' quality of life and causing premature death. TNF-α, regulated by the N...
Discerning the HLA allele and haplotype frequencies in the multiethnic population of Malaysia [0.03%]
马来西亚多元种族人群中HLA等位基因和单体型频率的识别
Wen Fei Kevin-Tey,Sean Wen,Ho Phin Chong et al.
Wen Fei Kevin-Tey et al.
The human leukocyte antigen (HLA) system is central to immune function, transplantation compatibility, and disease susceptibility. However, comprehensive data on HLA allele and haplotype distributions in Southeast Asia, particularly Malaysi...
Potential synergistic role of pre-formed GSTT1 antibodies and de novo HLA antibodies in a heart-transplant recipient diagnosed with AMR [0.03%]
术前存在的GSTT1抗体和术后新形成的HLA抗体在心脏移植后AMR患者中的协同作用研究
Nilesh S Chitnis,Maanika Nunugonda,Catherine Foye et al.
Nilesh S Chitnis et al.
Our center had a case of a 20-year old female with severe bi-ventricular dysfunction, leading to heart transplantation. Strong GSTT1 antibody was detected pre-transplant, which encouraged us to further study its possible significance. Gluta...
HLA-E gene polymorphism and expression in colorectal cancer patients [0.03%]
结直肠癌患者中的HLA-E基因多态性与表达量研究
Sabrine Dhouioui,Nadia Boujelbene,Marwa Hasni et al.
Sabrine Dhouioui et al.
HLA-E has been proposed as an immunomodulatory molecule in various physiological and pathological contexts. However, few data are available on its involvement in bowel oncogenesis. Our aim was to investigate whether HLA-E gene polymorphism ...
Recovery from Post-Renal transplant lymphopenia Predicts graft function and survival [0.03%]
移植后淋巴细胞减少的恢复预测移植物功能和生存率
Kevin Eappen,Paul Morrissey,Daithi S Heffernan
Kevin Eappen
Renal transplantation remains the gold standard for treating end-stage renal disease, yet early identification of patients at risk for graft dysfunction is essential to improving outcomes. Lymphocytes play a key role in the immune response ...
Prolonged wait times among highly sensitized HLA-B46 homozygous kidney transplant candidates [0.03%]
HLA-B46纯合子肾移植受者的长时间等待时间增加
Carrie L Butler,Loren Gragert,Anh Du et al.
Carrie L Butler et al.
Background: Individuals who are homozygous for HLA-B46 lack shared epitopes with most other HLA-B antigens and are capable of developing antibodies against all non-self B antigens including Bw4 and Bw6 epitopes. We identi...
Study of the association of LILRB2 gene polymorphisms with colorectal cancer susceptibility and prognosis in Tunisian population [0.03%]
LILRB2基因多态性与突尼斯人群结直肠癌易感性和预后的相关性研究
Malek Ferjani,Sabrine Dhouioui,Hager Bourogâa et al.
Malek Ferjani et al.
Background: leukocyte immunoglobulin-like receptors subfamily B member 2 (LILRB2), a receptor with immunosuppressive properties belonging to the Leucocytes Ig-Like receptors (LILR) family, is extensively detected in vario...
Increasing the liver donation pool: Eculizumab desensitization for ABO-incompatible living donor liver transplantation - A case series [0.03%]
增加供肝来源：抗ABO血型不合活体肝移植中依库珠单抗脱敏作用的病例报告
Mario Spaggiari,Maria Jimena Alaniz,Elif Kortan et al.
Mario Spaggiari et al.
Introduction: ABO-incompatible living donor liver transplantation (ABO-I LDLT) is limited by the risk of antibody-mediated rejection (AMR) from preformed anti-A/B antibodies. Conventional desensitization with therapeutic ...
Pleiotropic gene mapping Reveals shared immune regulatory hubs across 15 autoimmune diseases [0.03%]
多表型基因定位发现15种自身免疫性疾病共有的免疫调节中心
Yi Jin,Hui-Min Lu,Xing-Hao Yu
Yi Jin
Background: Autoimmune diseases (AIDs) involve immune dysfunction with complex genetic underpinnings. This study examined genetic correlations and directional genetic associations across 15 AIDs to identify common immune ...