Implications of TLR4 Polymorphisms for Precision Therapeutics in Gram-negative Infections: An Ethnogeographic-Stratified Meta-Analysis [0.03%]
toll样受体4多态性对精准治疗革兰氏阴性菌感染的影响：基于族源地理学的分层meta分析
Beatriz Giraldo Ospina,Iván Alberto Lopera Castrillón,Sandra Catalina Garzón Castaño et al.
Beatriz Giraldo Ospina et al.
Purpose: To quantify definitively the impact of loss-of-function variants of Toll-like receptor 4 (TLR4) (Asp299Gly, rs4986790 and Thr399Ile, rs4986791) on the susceptibility to, and mortality from, Gram-negative bacteria...
Assessing the Efficacy of Cannabinoid Compositions for Treating 3 Classes of Chronic Pain: A Real-World Evidence Study [0.03%]
评估大麻素组合治疗3种慢性疼痛的疗效：真实世界证据研究
Daniel J Kruger,Tyler Dautrich,Branden Hall et al.
Daniel J Kruger et al.
Purpose: Cannabis has been determined to be effective at treating chronic pain, although research on the effects of specific cannabinoids, especially for different mechanisms of chronic pain, is limited. This study examin...
Response to Letter to the Editor Regarding "The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera Estrogen Receptor Degrader, in Healthy Adult Participants" [0.03%]
关于“伊曲康唑对健康成人伏德gesrant药代动力学影响”的来信回复
Lana Tran,Jennifer A Winton,Kyle T Matschke et al.
Lana Tran et al.
Paul Beninger
Paul Beninger
BYSANTI (milsaperidone) [0.03%]
米螺环酮
Paul Beninger
Paul Beninger
Global Trends in Fixed-Dose Combination Drug Development: Regulatory Alignment and Structural Insights From FDA, EMA, and MFDS Approvals (2016-2024) [0.03%]
固定剂量复方药物研发的全球趋势：来自FDA、EMA和MFDS批准（2016-2024）的法规一致性和结构见解
Myung-Ah Chung,Eunjoo Pacifici
Myung-Ah Chung
Purpose: This study analyzes all fixed-dose combination (FDC) products approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), and Ministry of Food and Drug Safety (MFDS) from 2016 to 2024 to ...
Efficacy and Safety of a Tacrolimus Lipid Suspension Enema in Mild-to-Moderate Ulcerative Colitis: A Multicenter, Prospective, Double-Blind, Phase II Randomized Controlled Trial [0.03%]
一项针对轻至中度溃疡性结肠炎患者的有效性和安全性的他克莫司脂质悬液灌肠的多中心前瞻性双盲二期随机对照试验
Imran Ahmad,Alok R Chaturvedi,Amit Jain et al.
Imran Ahmad et al.
Purpose: A novel tacrolimus lipid suspension (TLS) enema was developed for the management of mild-to-moderate mesalamine-refractory ulcerative colitis (UC). The aim of this study was to evaluate the efficacy and safety of...
Switching to a Low Global Warming Potential Propellant in a Pressurized Metered-Dose Inhaler Does Not Affect the Pharmacokinetics of Combined Beclometasone Dipropionate/Formoterol Fumarate [0.03%]
低全球变暖潜势推进剂的更换不会影响布地奈德福莫特罗粉吸入剂型联合用药的药代动力学特征
Mafalda Almeida,Michela Salvadori,Massimo Corradi et al.
Mafalda Almeida et al.
Purpose: Use of high global warming potential propellants (eg, 1,1,1,2-tetrafluoroethane [HFA-134a]) in pressurized metered-dose inhalers (pMDIs) is being phased down. Extrafine formulation of beclometasone dipropionate (...
Navigating New Tensions: An Early Childhood Case of Intracranial Hypertension With CFTR Modulator Therapy [0.03%]
新形势下的紧张关系：一例接受CFTR调节剂治疗的颅内高压早发病例
Benjamin Legere,Paola Orozco,Sabrina Genovese et al.
Benjamin Legere et al.
Real-world Impact of GLP-1 Receptor Agonists on Health-related Quality of Life in Type 2 Diabetes and Obesity (SEVERAL Study) [0.03%]
胰高血糖素样肽-1受体激动剂对2型糖尿病和肥胖患者健康相关生活质量的现实世界影响（SEVERAL研究）
José Seijas-Amigo,Ángel Salgado-Barreira,Carlota Roca-Martinez et al.
José Seijas-Amigo et al.
Purpose: To evaluate the real-world impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on health-related quality of life (HRQoL) and metabolic outcomes in adults with type 2 diabetes and obesity. ...