Methicillin-resistant Staphylococcus aureus Nares Utility in Non-pneumonia Related Infections [0.03%]
MRSA鼻拭子在肺炎以外感染中的应用价值研究
Emily Pinto,Brian Ubhaus,Basil Taha et al.
Emily Pinto et al.
Purpose: There is an abundance of data to support the use of methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) swabs in pneumonia and to guide therapeutic decisions. Conversely, ther...
Early Feasibility Studies for Medical Devices: Insights From an Empirical Global Mapping [0.03%]
医疗器械早期可行性研究：一项实证全球调研的见解
Franco Luigi Zurlo,Carlo Federici,Maria Luisa Buzelli et al.
Franco Luigi Zurlo et al.
Purpose: Early feasibility studies (EFS) are a critical but poorly documented phase of clinical evidence generation for novel medical devices. Despite their growing relevance, no dedicated databases currently exist, limit...
Bridging Early Feasibility and Pivotal Trials: Insights From Transcatheter Tricuspid Valve Interventions [0.03%]
经导管三尖瓣介入治疗早期可行性研究与关键性试验设计衔接的启示
Monica Tocchi,Eleonora Capuzzi,Carolina Matsubayashi et al.
Monica Tocchi et al.
Purpose: Early feasibility studies (EFS) are critical in the clinical development of high-risk cardiovascular devices, enabling first-in-human evaluation and iterative refinement prior to pivotal investigation. Regulatory...
Adverse Drug Events Associated With Six Classes of Glaucoma Medications: A Retrospective Pharmacovigilance Study Using Real-World Data From The FAERS Database [0.03%]
基于真实世界数据的眼压降低药物不良事件回顾性研究
Yuqi Jiang,Shinan Wu,Yuling Chen et al.
Yuqi Jiang et al.
Purpose: Comparative post-marketing safety evidence across commonly used antiglaucoma drug classes remains limited. We conducted a real-world pharmacovigilance study to compare adverse event reporting patterns associated ...
Nutritional Support With Or Without Exercise for Older Adults With GLIM-Compatible Malnutrition: A Meta-Analysis of Randomized Controlled Trials [0.03%]
针对符合GLIM标准的老年人营养不良患者进行或不进行运动的营养支持的meta分析研究(randomized controlled trials)
Xin Liu,Zhaoxin Jiang,Pan Liu et al.
Xin Liu et al.
Purpose: This meta-analysis sought to evaluate whether the addition of exercise to nutritional support (NS) improves physical function compared with NS alone in older adults diagnosed with malnutrition retrospectively ver...
Sex-Specific Safety Profiles of PI3K Inhibitors: A Real-World Pharmacovigilance Study Based on FAERS Database [0.03%]
基于FAERS数据库的PI3K抑制剂性别特异性安全性特征的药物流行病学研究
Ximin Zhang,Weitao Lu,Dongyin Zou et al.
Ximin Zhang et al.
Purpose: This study aimed to investigate the sex-associated adverse events (AEs) reporting differences of phosphatidylinositol 3-kinase (PI3K) inhibitors from the US Food and Drug Administration Adverse Event Reporting Sy...
Cannabis Research, Policy, and Therapeutics: An International Quasi-Experiment in Cannabis Policy-Part 2 (2026) [0.03%]
大麻研究、政策和治疗学：一项关于国际类实验性大麻政策的研究（第二部分）(2026)
Julie K Johnson
Julie K Johnson
Paul Beninger,Larissa Garcia Pinto
Paul Beninger
Thyroid Immune-related Adverse Events Following Immune Checkpoint Inhibitors in NSCLC: Insights From Pharmacovigilance Data, a Retrospective Case-control Study, and Single-cell RNA Sequencing Dataset [0.03%]
基于药理警戒数据、病例对照研究和单细胞RNA测序数据分析免疫检查点抑制剂治疗NSCLC后甲状腺免疫相关不良事件的特征及机制
Xiaoyu Li,Qin Xiang,Yijia Gong et al.
Xiaoyu Li et al.
Purpose: Thyroid immune-related adverse events (irAEs) are common with immune checkpoint inhibitor (ICI) therapy in nonsmall cell lung cancer (NSCLC), but their drug-specific risks, clinical characteristics, and immune fe...
Pancreatitis Associated With Givosiran: A Real-World Pharmacovigilance Study Based on the FAERS and EudraVigilance Databases [0.03%]
基于FAERS和EudraVigilance数据库的givosiran药物警戒研究及其与胰腺炎相关的关联分析
Fang Li,Yinpeng Xu,Li Huang et al.
Fang Li et al.
Purpose: Givosiran is a small interfering RNA therapy approved for the treatment of acute hepatic porphyria. Although clinical trials have demonstrated its efficacy, pancreatitis-related adverse events (AE) have been repo...