Profiling of Potential Postmarket Risk Tracking and Pharmacovigilance Data for Avacopan [0.03%]
阿伐氯铵商业上市后再营销风险跟踪和药物流行病学数据的概要分析
Zhilan Zhou,Lurong Yu,Jiaoni Zheng et al.
Zhilan Zhou et al.
Purpose: Avacopan emerges as a significant therapeutic agent for the condition known as antineutrophil cytoplasmic antibody-associated vasculitis. However, there is a lack of current real-world safety studies with large s...
Paul Beninger
Paul Beninger
Study of Insulin Treatment Modalities in Adults With Cystic Fibrosis-Related Diabetes After Elexacaftor-Tezacaftor-Ivacaftor Therapy [0.03%]
艾莱加福韦/泰扎福韦/伊维卡福韦治疗后成人囊性纤维化相关糖尿病的胰岛素治疗研究
Luc Rakotoarisoa,François Lefebvre,Baptiste Arnouat et al.
Luc Rakotoarisoa et al.
Background: Several studies have shown improvements in glucose control after initiating elexacaftor/tezacaftor/ivacaftor (ETI) in cystic fibrosis-related diabetes (CFRD) patients. However, ETI's impact on insulin treatmen...
Analyzing Prescription Drug to Over-the-Counter Drug Switch Rejections: Understanding Regulatory Concerns, A Global Overview [0.03%]
从处方药转换为非处方药的失败分析：了解监管关注点，全球概览
Tais Uliana,Zeineb Lassoued,Sergio Moreno Restrepo et al.
Tais Uliana et al.
Purpose: Prescription-to-over-the-counter (Rx-to-OTC) switch applications face significant barriers, with many experiencing rejections despite potential public health benefits. The purpose of this article was to investiga...
Time Trends in Prescribing of Anxiolytic, Sedative, and Hypnotic Drugs in the United States [0.03%]
美国镇静、抗焦虑和安眠药物处方的流行度及其年代变化趋势分析
Zhengzhe Yang,Richard I Shader,David J Greenblatt
Zhengzhe Yang
Purpose: Sedative, anxiolytic, and hypnotic (sleep-promoting) medications are extensively prescribed in clinical practice. Most are benzodiazepine (BZ) receptor agonists, but other drug classes are prescribed as well. Rel...
Disease Severity and Healthcare Costs Associated With Chronic Kidney Disease in Patients With Systemic Lupus Erythematosus [0.03%]
系统性红斑狼疮患者慢性肾脏疾病的相关严重程度和医疗费用研究
Amy G Edgecomb,Shirley P Huang,Carlyne Averell et al.
Amy G Edgecomb et al.
Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune-mediated tissue injury. It frequently affects the kidneys, and lupus nephritis (LN) is the most severe manifestation affe...
The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera Estrogen Receptor Degrader, in Healthy Adult Participants [0.03%]
伊曲康唑对健康成人伏派德昔兰药代动力学影响的研究
Lana Tran,Jennifer A Winton,Kyle T Matschke et al.
Lana Tran et al.
Purpose: Vepdegestrant (ARV-471) is an orally administered PROteolysis TArgeting Chimera estrogen receptor (ER) degrader that directly binds an E3 ligase and ER to trigger ubiquitination and subsequent proteasomal degrada...
Pharmacokinetic Equivalence of AmphosomTM, a Newly Developed Liposomal Amphotericin B, to AmbisomeⓇ [0.03%]
一种新型的两性霉素B脂质体制剂AmphosomTM与Ambisome的药动学等同性研究
Seunghoon Han,Dong-Seok Yim,Sungpil Han et al.
Seunghoon Han et al.
Purpose: This study evaluated the bioequivalence of a newly developed liposomal amphotericin B (LAmB) formulation (DKF-5122, Amphosom™) relative to AmBisomeⓇ and mechanistically characterized the pharmacokinetic propert...
Cannabis Research, Policy, and Therapeutics-An International Quasi-Experiment in Cannabis Policy- Part 1 (2026) [0.03%]
大麻研究、政策和治疗学——一项关于国际类实验性大麻政策的研究（一）
Julie K Johnson,Graelyn Humiston,Alexander Colby
Julie K Johnson
Paul Beninger
Paul Beninger