Infrared Ion Spectroscopy Combined with Ion Mobility Spectrometry for Identification of Caffeine Metabolite Isomers and Protomers [0.03%]
红外离子光谱结合离子淌度光谱用于识别咖啡因代谢产物异构体和质子化形式
Gustavo Cervi,Thiago C Correra
Gustavo Cervi
Chromatography combined with tandem mass spectrometry is a conventional strategy for metabolite differentiation and identification. However, coelution and overlapping fragmentation patterns often limit confident assignment of isomeric and i...
Bram van de Put,Cindy Steven,Carolina O Pandeirada et al.
Bram van de Put et al.
The characterization of isomeric oligosaccharides, such as galactooligosaccharides (GOS), in complex mixtures is a long-standing analytical challenge. Due to the exponential increase in the number of possible structures with an increasing d...
Anatoly N Verenchikov,Jason Wildgoose,Sergey N Kirillov et al.
Anatoly N Verenchikov et al.
Mass spectrometry is an indispensable tool for the rapid and in-depth analysis of complex mixtures across diverse biologically important fields including metabolomics, lipidomics, and proteomics. These applications demand high speed instrum...
Matrix-Tolerant Quantification of THC and THCA in Complex Cannabis Products Using In-Sample Calibration with Multiple Isotopologue Reaction Monitoring [0.03%]
基于样本内校正的多重同位素反应监测的大麻素产品中四氢大麻酚及四氢大麻酚酸的矩阵容许量化方法研究
Yanfang Li,Mengliang Zhang
Yanfang Li
Accurate quantification of Δ9-tetrahydrocannabinol (THC) and Δ9-tetrahydrocannabinolic acid (THCA) across diverse cannabis- and hemp-derived products remains challenging due to severe matrix effects, wide concentration variability, and th...
Nitrile-Imine Cross-Linking in Peptide Ions with Aromatic Amino Acid Residues: Are Ring-Stacking Interactions Important? [0.03%]
含芳香族氨基酸残基的肽离子中的硝基烯亚胺交联：环堆积相互作用重要吗？
Chenxun Dai,Sizhong Shen,Dominik Halman et al.
Chenxun Dai et al.
Covalent conjugates of peptides containing aromatic amino acid residues Phe, Tyr, 3-nitro-Tyr, Trp, and 5-hydroxy-Trp with diaryltetrazole groups carrying 4-nitro and 4-methoxy substituents and linked to the peptide lysine were synthesized ...
Tandem FAIMS and IMS Combined with MS/MS for Effectively Probing the Structural Diversity of Proteins [0.03%]
用于有效探究蛋白质结构多样性的串联FAIMS-IMS与MS/MS结合的方法
Kaiqun Wu,Rong Liu,Zhonghan Hu et al.
Kaiqun Wu et al.
A three-dimensional gas-phase ion separation instrument platform that integrates high-sensitivity and high-resolution racetrack field asymmetric waveform ion mobility spectrometry (r-FAIMS) with quadrupole time-of-flight mass spectrometry (...
Characterization and Manipulation of Ion Clouds Inside an FT-ICR Instrument: A Laser Tomography Perspective [0.03%]
傅里叶变换离子回旋共振仪中激光断层扫描视角下的离子团簇的表征及操控研究
Cynthia M Suarez,Francis O Talbot,Rebecca A Jockusch
Cynthia M Suarez
The efficiency of many tandem mass spectrometry (MS/MS) techniques depends on the position of the trapped ion cloud and its overlap with a beam of photons or electrons. Here, we report photoactivated tomography profiles measured in a Fourie...
Deep Ultraviolet Laser Ablation Electrospray Ion Mobility Mass Spectrometry [0.03%]
深紫外激光解吸电喷雾离子淌度质谱法
Kelcey B Hines,Neda Feizi,Touradj Solouki et al.
Kelcey B Hines et al.
A solid-state deep ultraviolet (DUV) optical parametric oscillator (OPO) at 206 nm wavelength was utilized for laser ablation electrospray postionization of peptides and proteins coupled with ion mobility mass spectrometry (IM-MS) analysis....
Machine Learning for Individual EV Classification Based on Highly Sensitive Multiplexed Mass Spectrometry Measurements [0.03%]
基于高灵敏度多路质谱测量的个人EV分类机器学习方法
Muhammad Ramzan,Francis E Godfrey,Anthony Giron et al.
Muhammad Ramzan et al.
Here, we report on combining Random Forest (RF) classification with nanoprojectile secondary ion mass spectrometry (NP-SIMS) to analyze single extracellular vesicles (EVs) isolated from human liver cancer (HEPG2) and Normal liver cell lines...
A Native-MS Study of Charge-Driven Interactions of Glycosaminoglycans with Lactoferrin Underlying Its Immunoprotective and Immunomodulatory Properties [0.03%]
关于乳铁蛋白免疫保护和免疫调节特性的原位本征电母离子淌度质谱研究
Ruolan Cheng,Daniil G Ivanov,Yi Du et al.
Ruolan Cheng et al.
Apart from its role as a nutrient in mammalian milk, lactoferrin (LF) is also an important part of the innate immune system, where it functions as a potent microbicidal molecular factor. An important structural feature of LF, which makes it...