Unveiling Ciprofloxacin Protonation Isomers: an Integrated Approach with Mass Spectrometry, Ion Mobility Spectrometry and Infrared Ion Spectroscopy [0.03%]
质谱、离子淌度谱及红外光离子谱综合联用研究环丙沙星的 protonation 异构体
Lara van Tetering,Jelle L Schuurman,Jens Soltwisch et al.
Lara van Tetering et al.
Ciprofloxacin is a widely studied fluoroquinolone antibiotic and serves here as a relevant test case for molecules exhibiting multiple protonation isomers (protomers) with abundances that vary depending on the ionization conditions using ma...
Linkage between Quaternary Structure and Subunit Sequencing of Zebra Finch Hemoglobin via Hyphenation of Size Exclusion Chromatography with Native Top-Down Mass Spectrometry [0.03%]
基于尺寸排阻色谱与原位顶空质谱联用的四膜结构血红蛋白亚基序列关联性研究
Léa Letissier,Corentin Beaumal,Turkan Nabiyeva et al.
Léa Letissier et al.
Hemoglobin is the protein responsible for oxygen transport in many vertebrates, and any structural alteration can lead to health issues. Although well characterized in humans, it is less known for birds. Studies have reported the identifica...
Single-Ion Imaging Native Mass Spectrometry: Unraveling the Structural Features and Dissociation Energetics of Macromolecular Assemblies [0.03%]
单离子成像质谱原位解译大分子复合物的结构特征及裂变能基质科学快报封面文章：实现蛋白质复合物的纳米到微米尺度高分辨单颗粒成像及其化学组分分析
Anjusha Mathew,Leonor Mendes Godinho da Silva Veloso,Frans Giskes et al.
Anjusha Mathew et al.
We explore mass-resolved imaging of fragments generated from single macromolecular assembly (MMA) ions on a custom-built Orbitrap/time-of-flight (TOF) mass spectrometer with integrated UV photodissociation (UVPD) and a position- and time-se...
A Chemical Ionization Residual Gas Analyzer for the Sensitive Detection of Atmospheric Trace Gases [0.03%]
一种用于敏感检测大气痕量气体的化学电离残余气分析仪
Kevin A Wokosin,Matthew C Zoerb,Timothy H Bertram et al.
Kevin A Wokosin et al.
We have developed a compact, chemical ionization mass spectrometer for the sensitive detection of atmospheric trace gases using a commercial residual gas analyzer (RGA). A high-pressure ion molecule reactor interface incorporating two radio...
Spatiotemporal Mapping of Drug Incorporation in Human Nails by MALDI-FTICR-MSI [0.03%]
基于MALDI-FTICR-MSI的人类指甲药物渗透的时空映射分析
Bryn Flinders,Rogier van der Hulst,Ron M A Heeren et al.
Bryn Flinders et al.
Keratinized matrices, such as hair, are used in forensic toxicology as an alternative sample for a retrospective view of drug use. However, the analysis requires extensive sample preparation and analysis using chromatographic techniques, su...
Benchmarking MS/MS Featurization Strategies for Machine Learning-Driven Metabolite Structure Annotation [0.03%]
基于机器学习的代谢物结构注释的MS/MS表征策略 benchmarking
Roger Giné,Ivan Pérez-López,Josep M Badia et al.
Roger Giné et al.
Reference MS/MS libraries remain incomplete due to the vast chemical diversity of metabolites, leaving many spectra from untargeted metabolomics experiments unannotated─the "dark matter" of metabolomics. Machine learning can extend metabol...
Inter-Individual Variability in Exercise-Induced Metabolic Responses Revealed by Breath and Blood High-Resolution Mass Spectrometry-Based Metabolomics [0.03%]
基于呼吸和血液的高分辨率质谱代谢组学揭示运动诱导的代谢反应的个体差异性
Jianming Yang,Zhifeng Tang,Xiaolan Hu et al.
Jianming Yang et al.
Interindividual heterogeneity represents a major challenge for precise monitoring of exercise-induced physiological responses. In this study, a metabolomics-based framework was established to investigate individual variability in metabolic ...
Correction to "Multi-Laboratory Assessment Reveals Variable Ion Species Profiles in Electrospray Ionization Mass Spectrometer" [0.03%]
对“多实验室评估揭示了在电喷雾离子化质谱仪中离子物种轮廓的变化”的纠正
Melanie T Odenkirk,Jacqueline M Chaparro,Nathan T Montgomery et al.
Melanie T Odenkirk et al.
Published Erratum
Journal of the American Society for Mass Spectrometry. 2026 Jun 9. DOI:10.1021/jasms.6c00211 2026
Leveraging 13C-Labeling to Assign Molecular Formulas to Unknown Yeast Metabolites [0.03%]
利用碳-13标记确定未知酵母代谢物的分子式
Xi Xing,Wenyun Lu,Xi Li et al.
Xi Xing et al.
Mass spectrometry analyses have identified tens of thousands of unknown small molecule-associated peaks in different biological specimens. Notably, even the simplest and best studied organisms like Escherichia coli and Saccharomyces cerevis...
Investigating Polymerization of Ethyl Cyanoacrylate During Fuming of Latent Fingerprints [0.03%]
乙基氰基丙烯酸酯潜指纹熏显过程中聚合机理研究
Mariska Banidol,Théo Voellinger,Gihane El Khiri et al.
Mariska Banidol et al.
Despite being widely used in forensic laboratories to reveal latent fingerprints, the polymerization mechanism occurring during cyanoacrylate fuming is still not clearly established. Notably, mass spectra of the so-produced polymers have ne...