Akeem Sanni,Abderrahmane Koraich,Judith Nwaiwu et al.
Akeem Sanni et al.
Gangliosides are structurally diverse, low-abundance glycosphingolipids central to neuronal signaling and cancer progression; however, their quantitative analysis is hindered by low ionization efficiency, structural heterogeneity, and compl...
Proton Transfer Charge Reduction Enables Isobaric Labeling-Based Proteoform Quantification of Overlapping Signals in Top-Down Mass Spectrometry [0.03%]
Philipp T Kaulich,Andreas Tholey
Philipp T Kaulich
Top-down mass spectrometry provides a powerful approach for analyzing and quantifying intact proteoforms, i.e., the distinct molecular forms of proteins. Isobaric labeling-based quantification strategies offer the advantages of multiplexing...
Rapid Profiling and Real-Time Monitoring of Volatile Compounds Using a Low-Pressure Photoionization Source Combined with an Orbitrap Mass Spectrometer [0.03%]
Hamna Qayyum,Chunchun Lv,Yaya Wang et al.
Hamna Qayyum et al.
This study employed a low-pressure photoionization source combined with an orbitrap mass spectrometer (LPPI-MS) for rapid and comprehensive profiling of volatile organic compounds (VOCs) across chemically diverse biological samples. Garlic ...
Addressing the Oxygen in the Room: Exploring the Formation of Oxygenated Species for Nitazene Analogs Using DART-MS [0.03%]
Emma K Hardwick,Alleigh N Couch,J Tyler Davidson
Emma K Hardwick
Direct analysis in real time-mass spectrometry (DART-MS) is a technique well suited for screening seized drug samples as it enables rapid analysis with minimal sample preparation. Therefore, information present in full scan mass spectra is ...
Andrea Kosinova,Jiri Gruz
Andrea Kosinova
The increasing size and complexity of mass spectrometry (MS) data sets necessitate advanced computational tools. This study presents Correland, a MATLAB-based software for clustering and visualizing metabolite correlations through weighted ...
Native Top-Down Mass Spectrometry Combined with High-Resolution Charge Variant Analysis of Trastuzumab Originator and Biosimilars [0.03%]
原研赫赛汀及仿制药的高分辨电荷异构体和自上而下质谱分析
Corentin Beaumal,Kristina Srzentić,Sara Carillo et al.
Corentin Beaumal et al.
Comprehensive characterization of monoclonal antibody (mAb) charge heterogeneity is essential to ensure product quality, maintain batch consistency and support biosimilar development. Charge variant analysis (CVA) is widely used to separate...
Quantitative Host Cell Protein Analysis of Antibody-Based Protein Therapeutics Using the Orbitrap Astral Mass Spectrometer [0.03%]
采用Orbitrap Astri质谱仪对基于抗体的蛋白质药物进行定量宿主细胞蛋白分析
Josh Smith,Aaron Richardson,Corentin Beaumal et al.
Josh Smith et al.
Host cell proteins (HCPs) are endogenous proteins generated in cellular production systems alongside the biotherapeutic of interest. Removal of HCPs is crucial as they can be detrimental to product efficacy and patient safety. Due to its ab...
Avoiding False Identification of 7-Hydroxymitragynine in Kratom Products Using a Multicriteria LC-MS Confirmation [0.03%]
使用多标准LC-MS确认法避免 kratom产品中7-羟基弥特可因的假阳性识别
Daniel Sheehan,Yanfang Li,Emily Meckler et al.
Daniel Sheehan et al.
Kratom (Mitragyna speciosa) products have become widely available in diverse commercial formulations, raising increasing analytical and regulatory interest due to the presence of potent alkaloids such as mitragynine (MG), 7-hydroxymitragyni...
Deterministic Acceptance Limits for Statistical Equivalence Testing in Hydrogen/Deuterium Exchange Mass Spectrometry [0.03%]
氢/氘交换质谱统计等效性检验的确定性判定限值
Péter Lénárt,Viktor Háda,Kinga Komka et al.
Péter Lénárt et al.
Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) is a unique, rapidly evolving technique that has been widely adopted for the characterization of the higher-order structure of proteins. Numerous statistical tools are available in the ...
Experimental and Computational Investigation of Sulfur Chemistry in the DART-MS Gas Stream: Implications for the Interpretation of the Mass Spectra of Organic Disulfides [0.03%]
DART-MS气流中硫化学的实验和计算研究：对有机二硫化物质谱图解释的影响
Benedetta Garosi,Parandaman Arathala,Rabi A Musah
Benedetta Garosi
Direct analysis in real time-high-resolution mass spectrometry (DART-HRMS) has proven useful for the detection and faithful representation of labile organosulfur compounds (OSCs). Nevertheless, it has been found that when exposed to the met...