Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry [0.03%]
基于串联和电子激发诱导解离碎裂的糖肽唾液酸连接表征研究
Takashi Baba,Grant Godbehere,Ushio Takeda et al.
Takashi Baba et al.
In our previous publication [Anal. Chem. 2023, 95, 7458-7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging because its diagnostic capabilities depen...
Correction to "Characterization of Mobility-Dependent Ion Confinement in Rotating Electric Fields" [0.03%]
"旋转电场中与迁移率相关的离子约束特性研究”的修正
Jung Yun Lee,Sandilya V B Garimella,Randolph V Norheim et al.
Jung Yun Lee et al.
Rapid Antibody Structural Characterization and Quantification via Microdroplet Trypsin Digestion [0.03%]
基于微滴胰酶消化的快速抗体结构表征与定量分析方法
Mengyuan Xiao,Yongqing Yang,Andrew Schladebeck et al.
Mengyuan Xiao et al.
Microdroplet digestion of proteins, including monoclonal antibodies (mAbs), has gained increasing attention for its potential in rapid protein structural characterization. In this study, we developed a fast antibody characterization and qua...
Mass Spectrometry Monitoring of Water Dimer Radical Cations for Highly Efficient Dye Degradation [0.03%]
高效降解染料的水二聚体自由基阳离子质谱监测研究
Wen Li,Xinru Hu,Shuanglong Wang et al.
Wen Li et al.
The practical application of advanced oxidation processes is often constrained by their high energy consumption and dependence on chemical additives. To overcome these limitations, this work harnesses the highly reactive species water dimer...
Quantifying Oxidized Methionines with Mass Spectrometry to Map the Surface of Hamster Prion Strains Sc237 and 139H [0.03%]
用质谱法量化氧化甲硫氨酸以绘制仓鼠Sc237和139H毒株朊病毒表面图式
Christopher J Silva,Melissa L Erickson Beltran
Christopher J Silva
Sc237 and 139H are two phenotypically different prion strains of hamster (Mesocricetus auratus) adapted scrapie. Each replicates by inducing the natively expressed hamster PrPC to adopt its infectious conformation. The nine methionines in h...
Félix Truong,Laurent Nahon,Alexandre Giuliani
Félix Truong
Photon activation is a powerful means of inducing controlled fragmentation in mass spectrometry, but the simultaneous activation of multiple precursor ions may produce multiplexed tandem mass spectra that are difficult to interpret. In this...
Influence of Methylating the Serine Side Chain on the Decomposition of Protonated Asparaginyl Serine: GIBMS, IRMPD, and Theoretical Modeling Studies [0.03%]
甲基化对天冬氨酰丝氨酸质子化丝氨酸分解的影响：GIBMS，IRMPD和理论建模研究
Samantha K Walker,Tobias Dijkhuis,Marissa Bullard et al.
Samantha K Walker et al.
This study examines the decomposition of the protonated dipeptide, AsnSer methylated on the serine side chain, Asn(OMe)Ser. We utilize threshold collision-induced dissociation (TCID) conducted on a guided ion beam tandem mass spectrometer (...
On the Utility of Infrared Photoactivation for Native Top-Down and Complex-Down Orbitrap Mass Spectrometry of Soluble Proteoform Complexes [0.03%]
关于红外光活化在可溶性蛋白质复合物的天然顶向下和复杂向下轨道质量测定中的实用性研究
Cynthia Nagy,Linda B Lieu,Christopher Mullen et al.
Cynthia Nagy et al.
Cellular functions arise from the coordinated action of proteoforms, which typically form multiproteoform complexes (MPCs), rather than functioning as isolated molecular entities. Deciphering the architecture and composition of MPCs is esse...
Rapid Generation of Tandem Mass Spectrometry Reference Libraries Using Immediate Drop-on-Demand Liquid Handling Coupled to an Open Port Sampling Interface [0.03%]
基于即刻液滴按需液体处理与开放端口采样接口的串联质谱参考库的快速生成方法
Emily A Kurfman,Vilmos Kertesz,John F Cahill
Emily A Kurfman
In metabolomics, tandem MS (MS2) fragmentation libraries are important for the identification of unknown features, but generating these libraries takes many valuable hours of instrument and operator time. Here, an immediate droplet-on-deman...
Improved High-Throughput Platform for In-Cell Fast Photochemical Oxidation of Proteins via an Automated XY Stage (AXYS) [0.03%]
通过自动XY平台（AXYS）改进的高通量细胞内快速光氧化蛋白质技术平台
Jalah J Morris,Carlynda Lee,Tristan Q Thai et al.
Jalah J Morris et al.
Mass spectrometry (MS)-based protein footprinting and, more specifically, fast photochemical oxidation of proteins (FPOP) are methods that have been found to be important for studying proteins, their structures, and their relationships to o...