Laser-Induced Acoustic Desorption/Dichloromethane-Enhanced Vacuum Ultraviolet Photoionization Mass Spectrometry for Analysis of Amino Acids [0.03%]
激光诱导声脱附/氯仿增强真空紫外光离子化质谱法分析氨基酸
Yongze Gao,Lixin Shan,Lifeng Ding et al.
Yongze Gao et al.
Laser-induced acoustic desorption (LIAD) enables the soft volatilization of nonvolatile and thermally labile compounds as neutral molecules from metal surfaces. Concurrently, doping with dichloromethane (CH2Cl2) during vacuum ultraviolet ph...
Chiral α-Hydroxy Acid Discrimination in Tumor Tissues and Food Samples via Derivatization-Assisted MALDI-TIMS-MS [0.03%]
手性α-羟基酸的衍生化辅助MALDI-TIMS-MS鉴别分析（肿瘤组织及食品样品）
Simin Zhang,Thomas K Y Lam,Jianing Wang et al.
Simin Zhang et al.
Effective differentiation of chiral metabolites, coupled with precise determination of their enantiomeric ratios, is crucial for advancing biomarker screening and gaining comprehensive insight into the etiology of metabolic disorders. Herei...
Anne Brenner,J D Brookbank
Anne Brenner
Benefits of Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots in Lipid A Analysis [0.03%]
场不对称离子淌度谱和肯德里克质量缺陷图在脂质A分析中的优势
Trevena N Youssef,Abanoub Mikhael,David R Goodlett et al.
Trevena N Youssef et al.
Lipid A, the endotoxic component of Gram-negative bacterial lipopolysaccharide (LPS), consists of a phosphorylated glucosamine disaccharide backbone with variable fatty acyl chains. It is central to bacterial virulence and immune activation...
Yuze Zhao,Bingsheng Tu
Yuze Zhao
This paper presents an optimization method for the imperfect potential field of a segmented-electrode Orbitrap. The segmented-electrode Orbitrap consists of a complete cylindrical inner electrode and a set of concentrically arranged segment...
Ambient Ion Focusing from a Field-Free Region to a Detector: Enhanced Signal for Explosives and Drug Detection with Mass Spectrometry [0.03%]
从场自由区域聚焦到检测器的环境离子：用质谱法增强爆炸物和毒品检测信号
Elizabeth H Denis,Shannon E Schrader,Garret L Hart et al.
Elizabeth H Denis et al.
This study demonstrates ion focusing at ambient pressure and increased ion signal by creating a voltage difference from a field-free region to a detector, thereby improving the detection of chemicals such as explosives and drugs. At ambient...
Quantification of D-Amino Acids in Type 1 Diabetes-Affected Human Serum [0.03%]
1型糖尿病影响的人类血清D-氨基酸的定量分析
Shuangshuang Chen,Cindy J Lee,Tian A Qiu et al.
Shuangshuang Chen et al.
Recent advances in understanding the roles of d-amino acids (d-AAs) in nervous and endocrine systems have highlighted their emerging significance in cell-to-cell signaling, particularly in diabetes, where d-AAs are localized in specific isl...
Comparing Liquid Vortex Capture & the Rapid Droplet Sampling Interface for Single Cell Mass Spectrometry [0.03%]
液旋涡捕获与快速滴取接口在单细胞质谱分析中的比较研究
Stephen C Zambrzycki,Vilmos Kertesz,John F Cahill
Stephen C Zambrzycki
High-throughput single-cell mass spectrometry is a rapidly evolving field that requires innovative sampling and ionization techniques to balance speed, sensitivity, and reliability for metabolomic and lipidomic analyses. This study provides...
Profiling of Low-Abundance Branched-Chain Fatty Acids via Radical Directed Dissociation Tandem Mass Spectrometry [0.03%]
基于自由基调控解离的串联质谱分析痕量支链脂肪酸
Ruijun Jian,Shengzhuo Wang,Lipeng Qiao et al.
Ruijun Jian et al.
Branched-chain fatty acids (BCFAs) are key components of the bacterial lipidome, playing a role in regulating membrane fluidity and permeability. In mammals, BCFAs occur at much lower concentrations, and their functions remain largely unexp...
An Open-Source Platform for Reference Data-Driven Analysis of Untargeted Metabolomics [0.03%]
一个开源平台用于非靶向代谢组学参考数据驱动的分析
Alejandro Mendoza Cantu,Julia M Gauglitz,Wout Bittremieux
Alejandro Mendoza Cantu
Untargeted tandem mass spectrometry (MS/MS)-based metabolomics enable broad characterization of small molecules in complex samples, yet the majority of spectra in a typical experiment remain unannotated, limiting biological interpretation. ...