Integrating Ion Beam Control into a Commercial Platform for Improved Multimodal SIMS/MALDI Imaging [0.03%]
集成离子束控制的商用平台以改进多模态SIMS/MALDI成像技术
Kasper Krijnen,Sebastian Böhm,Jens Höhndorf et al.
Kasper Krijnen et al.
Mass spectrometry imaging (MSI) provides spatially resolved chemical analysis of surfaces and is widely applied in biological and biomedical research. Multimodal MSI can combine techniques such as secondary ion mass spectrometry (SIMS) and ...
Interpretable Machine Learning to Decipher Myelodysplastic Syndrome-Associated Alterations of the Extracellular Matrix by Time-of-Flight Secondary Ion Mass Spectrometry [0.03%]
基于二次离子质谱成像的骨髓增生异常综合征细胞外基质变化的解读研究
Ralf Zimmermann,Mirko Nitschke,Valentina Magno et al.
Ralf Zimmermann et al.
Machine learning (ML) accelerates progress in many areas, including biomedical and clinical research. ML algorithms provide powerful options for efficiently analyzing multivariate data sets. We developed and validated an ML pipeline to dete...
Maggie Tam,Francisco Fernandez-Lima
Maggie Tam
In Memory of Dr. Amina S. Woods: Visionary Mass Spectrometrist, Trailblazer in Molecular Neurobiology, and Devoted Mentor [0.03%]
缅怀阿米娜·S·伍兹博士：富有远见的质谱专家、分子神经生物学开拓者和敬业的导师
Scott Kuzdzal,Jonathan Ferguson,Shelley Jackson et al.
Scott Kuzdzal et al.
Exploring Fluoroquinolone Protomer Populations Formed with MALDI and Plasma Post-Ionization Mass Spectrometry [0.03%]
基于MALDI和等离子体后电离质谱研究氟喹诺酮药物的质子化形态分布
Boris Ucur,Brett R Hamilton,Marcel Niehaus et al.
Boris Ucur et al.
Molecules that possess more than one protonation site can form protonation site isomers (protomers) in mass spectrometry. During the ionization process, a change in protonation site can alter the resulting collision-induced dissociation mas...
Response Factor Correction for Quantitative Determination of Homooligomeric Sso SSB Binding to ssDNA by Native Mass Spectrometry [0.03%]
原位质谱测定Sso单体SSB与ssDNA结合定量分析的响应因子校正
Anthony J Blue,Miguel Rodriguez-Escalante,Raul A Villacob et al.
Anthony J Blue et al.
Native mass spectrometry (nMS) has emerged as a complementary approach for elucidating molecular parameters of biological complexes relative to solution-phase experiments. Herein, we utilize nMS to determine the subunit binding affinities (...
Exploring the Potential of Ultrafast Arylation for Capping Cysteine Residues with Fixed Charge Modifications [0.03%]
探索超快芳基化法用于半胱氨酸残基固定电荷修饰封端的潜力
Toma Chowdhury,Thomas A Shoff,Colomba Sanchez-Marsetti et al.
Toma Chowdhury et al.
Reduction of disulfide bonds in proteins followed by selective modification of Cysteine (Cys) residues is a common practice in proteomics experiments to facilitate digestion into peptides and ultimately identification by mass spectrometry (...
Rapidly Switchable Dual Ion Source Combining ESI with iLTP/Tube Plasma for LC-MS, Multi-2D LC × LC, and SLIM-IM-MS Applications [0.03%]
适用于LC-MS，多维2D LC×LC和SLIM-IM-MS应用的ESI与iLTP/管等离子源快速切换的双离子源
Marvin Häßler,Katharina Wetzel,Cedric Thom et al.
Marvin Häßler et al.
High-throughput analysis is becoming increasingly important in liquid chromatography-mass spectrometry coupling to minimize downtime for efficient and cost-effective operations in the analytical laboratory. In response to this need, a dual ...
Top-Down Characterization of Protein Anions Using Ultraviolet Photodissociation Mass Spectrometry [0.03%]
利用紫外光解质谱表征蛋白阴离子的自上而下方法
Hanlin Ren,Jennifer S Brodbelt
Hanlin Ren
Top-down proteomics is primarily performed using electrospray ionization-tandem mass spectrometry (ESI-MS/MS) in the positive mode. Development of methods in the negative mode can potentially facilitate analysis of acidic proteome, but has ...
Understanding m/ z Range Settings for MS/MS Scans: A Case Study with Intact Glycopeptides [0.03%]
MS/MS扫描的m/z范围设置的理解——以完整糖肽为例
Tim S Veth,Kathryn Kothlow,Nicholas M Riley
Tim S Veth
Effective glycopeptide identification with tandem mass spectrometry (MS/MS) often relies on both low mass-to-charge (m/z) ions derived from glycan-specific oxonium ions and higher m/z peptide fragment ions that retain glycan modifications. ...