Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer [0.03%]
改进数字四极杆/离子淌度/轨道阱质谱仪中的四级杆到离子淌流区域
Robert L Schrader,Gordon A Anderson,Kacie A Evans et al.
Robert L Schrader et al.
A quadrupole/drift tube ion mobility/Orbitrap instrument requires pumping from atmosphere to 10-5 Torr in the quadrupole analyzer region, back to 1 Torr for the drift tube, and a return to 10-5 Torr for the Orbitrap high vacuum region. The ...
Nathália Dos S Conceição,Alan R Pereira,Daniel S Trancoso et al.
Nathália Dos S Conceição et al.
Ambient Mass Spectrometry (AMS) has revolutionized forensic analysis by enabling rapid and direct detection of chemical compounds on complex surfaces with minimal or no sample preparation. Among AMS techniques, desorption electrospray ioniz...
Anne Brenner,J D Brookbank
Anne Brenner
Rapid Screening and Prioritization of Culture Conditions for Natural Product Discovery using the Liquid Microjunction Surface Sampling Probe [0.03%]
利用液相微界面表面采样探针进行天然产物发现的快速筛选和条件优先级确定方法
Jessie F Deng,Jennifer L Kolwich,Georgia Reed et al.
Jessie F Deng et al.
The discovery of novel bioactive compounds remains a cornerstone of natural product (NP) chemistry. However, traditional NP discovery workflows are time- and resource-intensive, hindering sustainability and efficiency of multicondition scre...
Damon Griffiths,Juan P Rincon Pabon,Charlotte Guffick et al.
Damon Griffiths et al.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful technique for studying protein structural dynamics. A critical step in the HDX-MS workflow is generating a peptide map from nondeuterated samples, which serves as the refe...
SLIMPHONY: A SLIM-Based Instrument That Orchestrates Complex Ion Mobility-Mass Spectrometry Experiments [0.03%]
SLIMPHONY：一种基于SLIM的用于编排复杂离子淌度质谱实验的工具
AnneClaire Wageman,Addison E Roush,Yuan Feng et al.
AnneClaire Wageman et al.
The inherent heterogeneity of biological macromolecules offers a unique challenge for analysis. The combination of ion mobility (IM) and mass spectrometry (MS) is sensitive to the size, shape, and dynamics of, for example, proteins and thei...
Structural Elucidation of Phosphatidylcholines via Radical-Directed Dissociation of [M + CuII + Anion]+ Ion Types [0.03%]
基于[M + CuII + 罐子]+离子类型的自由基导向裂解法阐释磷脂酰胆碱的结构
Zunaira Naeem,Tingting Yan,Julia R Bonney et al.
Zunaira Naeem et al.
Tandem mass spectrometry (MS/MS) is frequently used in phospholipid characterization to determine lipid class, fatty acyl chain length, and degree of unsaturation. However, conventional MS/MS methods are limited in characterizing isomeric l...
Characterizing the Energy Surfaces of Competing Pathways in Gas-Phase Charge Inversion Ion/Ion Reactions Involving Cationized Lipids and Anionic Diacids [0.03%]
表征气相脂质阳离子与多元酸阴离子反应中竞争途径的能量面
Yingchan Guo,Jonathan T Specker,Pratiksha B Gaikwad et al.
Yingchan Guo et al.
Accurate structural identification of lipids in mass spectrometry is essential for advancing lipidomics and achieving a holistic understanding of complex cellular systems. Gas-phase charge inversion ion/ion reactions, which allow for altera...
Feasibility of Rapid Regulatory Differentiation of TNF Receptor 2-Fc Fusion Protein Products from Various Manufacturers in the Chinese Market Using a Novel Mass Spectrometry-Based Multi-attribute Method (MAM) [0.03%]
一种基于新型质谱的多属性方法(MAM)，用于快速鉴别中国市场不同厂家TNFR2-Fc融合蛋白产品的可行性研究
Mengjiao Xu,Mingming Xu,Tao Liu et al.
Mengjiao Xu et al.
Ensuring the quality of pharmaceutical products, particularly for complex recombinant protein drugs such as TNF receptor 2-Fc fusion proteins (TNFR2-Fc, Etanercept), poses significant public health challenges. These products, including bios...
Unlocking PAH Ionization in Negative-Mode ESI Orbitrap MS Using Tetramethylammonium Hydroxide: A Petroleomic Strategy [0.03%]
基于乙醇
Deborah V A de Aguiar,Lidya C da Silva,Iris M Júnior et al.
Deborah V A de Aguiar et al.
The selective ionization of cyclopentadiene-derived polycyclic aromatic hydrocarbons (PAHs) in complex matrices remains a persistent challenge in direct ionization mass spectrometry, particularly under atmospheric pressure ionization (API) ...