Gas-Phase Discrimination of Histidine Epimers in Peptides by Silver-Cation-Assisted Energy-Resolved Mass Spectrometry [0.03%]
银离子辅助能量分辨质谱法鉴别肽中组氨酸异构体
Ella Tyson,Guillaume Cazals,Antony Memboeuf et al.
Ella Tyson et al.
Epimerization control of histidine residues during solid-phase peptide synthesis is a persistent challenge in the pharmaceutical industry. In this work, we demonstrate that energy-resolved mass spectrometry (ERMS) enables the direct differe...
Toward Molecular Forensics of Agrochemicals with Orbitrap IRMS: Isotopic Fingerprints of Imidacloprid Sources and Elucidating Hydrolysis [0.03%]
基于轨道离子阱同位素比质谱的农用化学品分子 forensics研究：氯虫苯甲酰胺的同位素指纹及水解机理剖析
Felix Niemann,Nils J Kuhlbusch,Annika Gruhlke et al.
Felix Niemann et al.
Imidacloprid (IMI) is a widespread neonicotinoid insecticide of environmental concern because of its ecotoxicity and persistence. Tracing its commercial sources and environmental transformation is difficult with concentration-based approach...
Minimizing the Coffee Ring Effect: Improving MALDI Dried-Drop Analysis by Sequential Spotting [0.03%]
减轻咖啡环效应：通过顺序点样改善MALDI干滴分析
Joy L Maabadi,Arbil Lopez,Joseph H Holbrook et al.
Joy L Maabadi et al.
In matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) experimentation, dried-drop analyses are valuable for their ease of preparation and the generation of efficient results. They hold value in their ability to assess ...
Ion Mobility Separation of Six Isomeric Cyclobutane Thymidine Photodimers Relevant to the Photochemistry of Non-B DNA Structures [0.03%]
用于非B型DNA结构光化学的六种环丁烷胸腺嘧啶二聚体异构体的离子淌度分离
Hsin-Chieh Yang,Savannah S Scruggs,Mengqi Chai et al.
Hsin-Chieh Yang et al.
Thymidine dimers, which exist in multiple stereoisomeric forms, are important UV-induced DNA lesions, yet their structural differentiation remains challenging. In this study, we leveraged trapped ion mobility spectrometry coupled with time-...
Use of Ion Oscillation Phase Values for Peak Classification and Noise Filtering Efficiency Estimation in Orbitrap Mass Spectra of Natural Organic Matter [0.03%]
离子振荡相值在Orbitrap质量谱天然有机物峰值分类及噪声滤除效率估算中的应用
Alexander A Potemkin,Mikhail A Proskurnin,Dmitry S Volkov
Alexander A Potemkin
An unprocessed high-resolution mass spectrum of natural organic matter contains tens of thousands of peaks, many of which are uninformative and associated with noise. Several noise filtering algorithms have been proposed in an attempt to re...
Mass Spectrometry-Based Proteomics Methods for Systematic Identification and Quantification of Protein O-Glycosylation in Complex Biological Samples [0.03%]
基于质谱的蛋白质组学方法系统鉴定和量化复杂生物样品中的蛋白质O-糖基化
Longping Fu,Xing Xu,Ronghu Wu
Longping Fu
Protein O-glycosylation is one of the most common and important modifications in human cells. It regulates protein folding, trafficking, stability, and interactions with other molecules, and its dysregulation is directly related to numerous...
Roberto A Ribas,Qun Tang,Scarlett I Caffee et al.
Roberto A Ribas et al.
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) is transforming spatial molecular studies. However, applying MALDI-MSI to small, anatomically complex tissues remains challenging. One such structure is the c...
Improved Methods for Recording Accurate Collision Cross Sections Using Cyclic Ion Mobility-Mass Spectrometry [0.03%]
利用环状离子淌度质谱精确记录碰撞横截面的改进方法
Devin M Makey,David Langridge,Keith Richardson et al.
Devin M Makey et al.
Traveling wave ion mobility (TWIM) is a gas-phase separation technique widely used in structural biology to rapidly probe protein conformational states and in complex mixture analysis to catalyze an array of chemical measurements. Analyte s...
Maggie Tam,Francisco Fernández-Lima
Maggie Tam