Optimization of Data-Dependent Acquisition Parameters in Mass Spectrometry for Oligonucleotide Identification [0.03%]
用于寡核苷酸识别的质谱数据依赖性采集参数优化
Audriy Jebet,Xipeng Ma,Liqing He et al.
Audriy Jebet et al.
Accurate characterization of RNAs and their chemical modifications is critical for understanding RNA biology and post-transcriptional regulation. Mass spectrometry using data-dependent acquisition (DDA) is a crucial tool for identifying oli...
Quantification of Staphylococcal Enterotoxins by Coupling Laser-Induced Dissociation and Mass Spectrometry [0.03%]
利用激光解吸和质谱联用技术定量金黄色葡萄球菌肠毒素
Annabelle Médalin,Benjamin Youenou,Cedric Badiou et al.
Annabelle Médalin et al.
Staphylococcal enterotoxins (SEs) make up a superfamily of virulence factors that make Staphylococcus aureus a major cause of food poisoning. The amount of SEs produced by a strain may correlate with its virulence; however, their accurate q...
Unimodal Imaging of Monovalent Metal-Chelator Complexes and Lipids by MALDI Imaging Mass Spectrometry [0.03%]
基于基质辅助激光解析电离的单价金属配体复合物和脂质的模态成像 масс-спектрометрическая мономодальная imagingimidation of monovalent metal-chelator complexes and lipids
Kes A Luchini,Joshua D Breidenbach,Ethan M McBride et al.
Kes A Luchini et al.
Careful regulation of monovalent metal ions (M+) is necessary to maintain a functional cellular system. Of these ions, appropriate sodium (Na+) and potassium (K+) concentrations are particularly integral for electrochemical signaling, as we...
Characterization and Elucidation of the Fragmentation Pathway of 17 Nitazenes by Liquid Chromatography High-Resolution Mass Spectrometry Using Collision-Induced Dissociation and Electron-Activated Dissociation [0.03%]
液相色谱高分辨率质谱结合碰撞诱导解离和电子活化 dissociation 对17种尼唑类药物的结构表征及碎片化机理研究
Miao Zhang,Hao Chen,Yiling Tang et al.
Miao Zhang et al.
Nitazenes, a class of new psychoactive substances, have emerged as a significant public health and safety concern due to their widespread abuse. While various detection methods, particularly mass spectrometry, have been developed for these ...
Isomer-Specific Analysis of PFOS in Wastewater and Avian Eggs Enabled by Cyclic Ion Mobility Spectrometry [0.03%]
基于循环离子淌度谱的全氟辛烷磺酸同分异构体在废水及鸟类蛋中的特异性分析研究
Jenise Z Paddayuman,Mindula K Wijayahena,John Michael N Aguilar et al.
Jenise Z Paddayuman et al.
Perfluorooctanesulfonic acid (PFOS) exists in the environment as a mixture of linear (L-PFOS) and branched (Br-PFOS) isomers. Although it is one of the most frequently detected per- and polyfluoroalkyl substances (PFAS), it is often analyze...
Space Charge Induced Dissociation Due to Extended Ion Accumulation Preceding Cyclic Ion Mobility Separation [0.03%]
扩展离子累积引发的空间电荷诱导解离用于循环离子淌度分离
Sudam S Mane,Easton K Cox,Kenneth W Lee
Sudam S Mane
Cyclic ion mobility spectrometry (cIMS) provides the potential for high resolution separations of small molecule isomers using multiple passes in a closed-loop geometry. Achieving this potential, however, is limited by the analyte stability...
Iterative SLIM (itSLIM) for Ultrahigh Resolution Targeted Ion Mobility Analysis [0.03%]
迭代式SLIM（itSLIM）用于超高分辨率靶向离子淌度分析
Liulin Deng,Ding Zhang,Leonard C Rorrer rd et al.
Liulin Deng et al.
We present a novel approach for achieving ultrahigh-resolution ion mobility (UHRIM) separations using a structures for lossless ion manipulation (SLIM) ion mobility-mass spectrometry (IM-MS) system. By incorporating a rounded-turn ion path ...
Going with the Flow: Mechanistic Insights into Slow Mixing Mode Native Mass Spectrometry [0.03%]
顺势而为：原位质谱分析的慢混模式机理洞察
Simar K Dhillon,Duong T Bui,Elena N Kitova et al.
Simar K Dhillon et al.
Slow mixing mode native mass spectrometry (SLOMO-nMS), which monitors the mixing of layered solutions within a nanoflow electrospray ionization (nanoESI) emitter, enables the accurate quantification of biomolecular complexes in vitro, even ...
Prediction of Collision-Induced Dissociation Spectra of Deprotonated Oligonucleotides [0.03%]
去质子寡核苷酸碰撞诱导解离光谱的预测
Zhongqi Zhang,Jason Richardson
Zhongqi Zhang
Developing DNA/RNA-based therapeutics (siRNA, antisense oligonucleotides, mRNA, etc.) requires comprehensive tools for structural characterization. MS/MS remains a main tool for structural characterization of short synthetic DNA/RNA or olig...
Strategies for Minimizing Interference from Metastable Water Clusters in ToF-SIMS 3D Imaging of Frozen Hydrated Biological Samples [0.03%]
减少ToF-SIMS冷冻水合生物样品三维成像中亚稳态水团簇干扰的策略
Michael Bäumer,Thorsten Adolphs,Richard E Peterson et al.
Michael Bäumer et al.
Cryogenic analysis of hydrated biological samples is required to retain their native three-dimensional structure during time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging. However, stable and metastable water cluster ions, or...