Cyclic IMS-MS Reveals Protonation-Site Preservation in Isobaric Fragments of Quizartinib Protomers via Charge-Remote Fragmentation [0.03%]
采用电荷远程裂解法研究Quizartinib各protomer的等重碎片中的质子位置保留：IMS-MS周期性实验分析
Sudam S Mane,David V Dearden,Kenneth W Lee
Sudam S Mane
The protonation site of a molecule can significantly influence its gas-phase behavior and fragmentation, especially when multiple protonation sites are accessible. Here, we characterize two gas-phase protonation site isomers (hereafter refe...
Application of a Gradient-Threaded Discrete Twisted Dipole Ion Guide (GTDIG) for High-Efficiency Ion Propulsion and an Expanded m/ z Bandwidth in Mass Spectrometry [0.03%]
用于高效离子推进和质谱增宽m/z带宽的梯度线程离散扭曲偶极子离子导管(GTDIG)的应用
Zhihao He,Xingliang He,Fulong Deng et al.
Zhihao He et al.
In mass spectrometry (MS), the radio frequency (RF)-only multipole ion guide commonly used in a medium pressure range (0.1-10 Pa) is susceptible to a collision-damping-induced loss of instrumentation sensitivity, resulting in operation with...
Development of Low-Flow High-Resolution Desorption Electrospray Ionization Mass Spectrometry Imaging [0.03%]
低流速高分辨率解吸电喷雾离子化质谱成像的开发
Mark W Towers,Rachel J DeHoog,Trevor M Godfrey et al.
Mark W Towers et al.
Desorption electrospray ionization mass spectrometry (DESI-MS) imaging is a well-established technique for molecular analysis of biological samples, although its spatial resolution has been limited when compared to other MS imaging techniqu...
A Radio Frequency Ion Guide for Transporting Cooled Ions Through Differential Vacuum Stages: Design and Simulation [0.03%]
一种用于通过不同真空级传输冷却离子的射频离子导引器：设计与模拟
Bingyin Xu,Weimin Wang,Huanming Wu et al.
Bingyin Xu et al.
In order to transport ions from an intermediate-pressure collisional cooling device to a planar electrostatic ion trap (PEIT) mass analyzer in an ultrahigh-vacuum chamber, a segmented radio frequency (RF) quadrupole system was designed and ...
Multiple Spectrum Alignment for Molecular Networking Exploration and Discovery [0.03%]
用于分子网络探索和发现的多光谱对齐技术
Amy Lau,Xianghu Wang,Tao Xu et al.
Amy Lau et al.
Molecular networking is a computational mass spectrometry technique used to visualize and connect tandem mass spectra from putatively related molecules to reveal structural relationships. Despite their utility, existing tools for interpreti...
Enhanced S-Palmitoylated Protein Detection by Mild Nonionic Detergent in Proteomic Workflow [0.03%]
改良的非离子型去污剂在蛋白质组学流程中增强S-棕榈酰化蛋白检测能力
Hyojung Kim,Jiraphorn Issara-Amphorn,SungHwan Yoon et al.
Hyojung Kim et al.
Loss of hydrophobic peptides and proteins remains a significant challenge in bottom-up proteomics, resulting in under-representation of membrane and membrane-associated proteins that are critical for understanding cellular function and dise...
Three-Dimensional (3D) Topographic Mass Spectrometry Imaging of Artemisia annua by UV-MALDESI [0.03%]
紫外激光解吸质谱技术进行黄花蒿三维地形分布分析
Sarah M Ashbacher,De-Yu Xie,Jeffrey G Manni et al.
Sarah M Ashbacher et al.
Matrix-assisted laser desorption electrospray ionization (MALDESI) enables mass spectrometry imaging (MSI) capabilities to reveal the localization of a wide range of biomolecules across an organism. Three-dimensional (3D) MSI of biological ...
CIeaD: A Complementary CID and EAD Mass Spectral Library for Phytochemicals [0.03%]
CIeaD：用于植物化学物质的补充CID和EAD质谱库
Yatendra Singh,Paul C Norris,Sibesh Maharjan et al.
Yatendra Singh et al.
Plant metabolomics faces major challenges in metabolite identification due to the structural diversity of plant metabolites and limited coverage in existing spectral libraries. To address this, we developed CIeaD (Collision-Induced and Elec...
SpecQuality: A Tool for Reliable Spectral Quality Assessment in Proteomics and Proteogenomics [0.03%]
SpecQuality：蛋白质组学和蛋白基因组学中可靠光谱质量评估工具
Alka Yadav,Uma Dhawan
Alka Yadav
Proteogenomics integrates genomics and mass spectrometry (MS) data to understand complex biological systems, disease mechanisms, and potential biomarkers. However, the high volume and noise in MS data present computational and interpretatio...
Theoretical Study of High-Order Velocity Focusing Achieved with Single-Stage Reflectron Time-of-Flight Mass Spectrometry [0.03%]
单级反射器飞行时间质谱中高阶速度聚焦的理论研究
Yi-Hong Cai,Yi-Sheng Wang
Yi-Hong Cai
This study explores unexplained fundamental principles of reflectron time-of-flight (R-TOF) mass spectrometry (MS). Conventional calculations focusing on the ion trajectory in reflectors concluded that multistage reflectors are necessary to...