Ion Heating in Advanced Dielectric Barrier Discharge Ion Sources for Ambient Mass Spectrometry [0.03%]
用于电离质谱的先进介质阻挡放电离子源中的离子加热研究
Marcos Bouza,Ezaz Ahmed,Priscilla Rocío-Bautista et al.
Marcos Bouza et al.
Dielectric barrier discharges (DBD) are highly versatile plasma sources for forming ions at atmospheric pressure and near ambient temperatures for the rapid, direct, and sensitive analysis of molecules by mass spectrometry (MS). Ambient ion...
New Insights into the Intrinsic Electron-Based Dissociation Behavior of Cytochrome c Oligomers [0.03%]
细胞色素c寡聚体内在的基于电子裂解行为的新见解
Sarah Brandner,Tanja Habeck,Frederik Lermyte
Sarah Brandner
Between 2003 and 2017, four reports were published that demonstrated the intrinsic ability of the native iron-containing proteins cytochrome c and ferritin to undergo radical-based backbone fragmentation in the gas phase without the introdu...
Resolving the Temporal Splenic Proteome during Fungal Infection for Discovery of Putative Dual Perspective Biomarker Signatures [0.03%]
利用蛋白质组学技术在真菌感染过程中解析时间上的脾脏蛋白变化并发现潜在的双重标志物信号
Benjamin Muselius,Florence Roux-Dalvai,Arnaud Droit et al.
Benjamin Muselius et al.
Fungal pathogens are emerging threats to global health with the rise of incidence associated with climate change and increased geographical distribution; factors also influencing host susceptibility to infection. Accurate detection and diag...
Minimally Invasive Liquid Microjunction Sampling to Identify Dye on a 17th Century Spanish Illuminated Manuscript [0.03%]
用于鉴定西班牙17世纪手稿上染料的微创液相微萃取采样技术
Hannah A Lawther,G Asher Newsome
Hannah A Lawther
Common sampling methods for mass spectrometry such as sectioning are undesirably damaging to cultural heritage objects. A liquid microjunction sampling technique is developed that uses minimal solvent volume for analysis. Painted illustrati...
Dissociation Kinetics in Quadrupole Ion Traps: Effective Temperatures under Dipolar DC Collisional Activation Conditions [0.03%]
四极离子阱中的解离动力学：二极直流碰撞活化条件下的有效温度
Samantha A Mehnert,Joshua L Fischer,Monica R McDaniel et al.
Samantha A Mehnert et al.
Ions stored in an electrodynamic ion trap can be forced from the center of the ion trap to regions of higher radio frequency (RF) electric fields by exposing them to a dipolar DC (DDC) potential applied across opposing electrodes. Such ions...
Radu Ionicioiu
Radu Ionicioiu
Accelerator mass spectrometry (AMS) is a widely used technique with multiple applications, including geology, molecular biology, and archeology. In order to achieve a high dynamic range, AMS requires tandem accelerators and large magnets, w...
Applying Automation and High-Throughput MALDI Mass Spectrometry for Peptide Metabolic Stability Screening [0.03%]
基于MALDI质谱的高通量肽类代谢稳定性筛选及自动化解决方案
Huifang Yao,Bingming Chen,Paul Harradine et al.
Huifang Yao et al.
The discovery of peptide therapeutics represents a fast-growing segment of pharmaceutical research. During the early discovery process, a large number of peptide candidates needs to be rapidly screened for metabolic stability in relevant bi...
Screening Clones for Monoclonal Antibody Production Using Droplet Microfluidics Interfaced to Electrospray Ionization Mass Spectrometry [0.03%]
基于液滴微流控和电喷雾离子化质谱的单克隆抗体筛选方法
Cara I D&#x;Amico,Gillian Robbins,Iris Po et al.
Cara I D&#x;Amico et al.
As one of the most critical steps in process development for protein therapeutics, clone selection and cell culture optimization require a large number of samples to be screened for high titer and desirable molecular profiles. Typical analy...
"Lab of the Future"─Today: Fully Automated System for High-Throughput Mass Spectrometry Analysis of Biotherapeutics [0.03%]
“未来实验室”今朝享：生物制剂高通量质谱分析的全自动系统
Hans E Waldenmaier,Elsa Gorre,Michael L Poltash et al.
Hans E Waldenmaier et al.
Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics. The system includes liquid and microplate handling robotics an...
Structure Determination of Lipid A with Multiple Glycosylation Sites by Tandem MS of Lithium-Adducted Negative Ions [0.03%]
通过锂离子加合的负离子串联质谱鉴定同时具有多个糖基化位点的脂类A结构
Hyojik Yang,Matthew E Sherman,Caitlyn J Koo et al.
Hyojik Yang et al.
FLATn is a tandem mass spectrometric technique that can be used to rapidly generate spectral information applicable for structural elucidation of lipids like lipid A from Gram-negative bacterial species from a single bacterial colony. In th...