Continuous Flow Paper Spray Ionization Mass Spectrometry for In-Depth Characterization of Anticancer Drugs in Tissues: Addressing Mass Spectral Complexity [0.03%]
连续流动纸喷雾电离质谱技术用于组织中抗肿瘤药物的深入分析：解决质谱复杂性问题
Pallab Basuri,Konrad Klinghammer,Oliver Klein et al.
Pallab Basuri et al.
We introduced continuous flow paper spray ionization mass spectrometry (CFPSI MS) for the rapid detection and characterization of anticancer drugs in solid tissue samples. CFPSI is a paper spray-based semiquantitative method using continuou...
Theropod: Software Tools to Analyze Externally Collected Selective Temporal Overview of Resonant Ions [0.03%]
特罗波德：分析外部收集的选择性时变共振离子的软件工具
Timothy P Cleland,Michael G Trizna
Timothy P Cleland
Recent developments in charge detection mass spectrometry have allowed for the broad characterization of individual proteoforms and mixtures of proteoforms from individual ions collected in Orbitrap mass spectrometers. In this study, we des...
Non-proximate, Hand-Held Probe with Positional Feedback for Real-Time Analysis of Three-Dimensional Object Surfaces [0.03%]
具有位置反馈的非接触式便携探头，用于三维物体表面的实时分析
G Asher Newsome
G Asher Newsome
A variety of non-proximate mass spectrometry techniques have been implemented to sample organic analytes from distant surfaces, but they frequently risk signal carryover and loss by relying on unheated plastic tubing to transfer analytes ba...
Taxonomic-Level Protein Quantification in Metaproteomics Using a Biomass-Constrained Expectation-Maximization Approach [0.03%]
基于生物量约束期望最大化方法的元蛋白质组学中基于分类号的蛋白定量研究
Gelio Alves,Mehdi B Hamaneh,Aleksey Y Ogurtsov et al.
Gelio Alves et al.
Microbiome communities are found across diverse environments and play critical roles in both ecosystem function and human health. Mass-spectrometry-based metaproteomics provides a powerful means for directly identifying and quantifying micr...
Comparison of Real-Time and Offline Mass Spectrometry Methods for Quantitation of Fluorotelomer Alcohols in Aqueous Film-Forming Foam Headspace [0.03%]
顶空分析法测定水成膜泡沫中氟碳醇的在线质谱与离线质谱定量方法比较研究
Gabrielle V West,Kenneth S Docherty,Matthew S Clifton et al.
Gabrielle V West et al.
Per- and polyfluoroalkyl substances (PFAS) are highly water-, grease-, and heat-resistant compounds known as "forever chemicals" due to their resistance to degradation. Aqueous film-forming foams (AFFFs) are PFAS-containing firefighting foa...
Jack Henion
Jack Henion
This Account is a personal perspective on the development of the current atmospheric pressure ionization (API) LC/MS techniques. These include atmospheric pressure chemical ionization (APCI), which appeared first, followed by electrospray i...
Optimization of Electric Field Traveling Waves in SLIM Platforms for Improved Resolution via Analytical Solutions of the Nernst-Planck Equation [0.03%]
基于Nernst-Planck方程的解析解提高SLIM平台分辨率的电场 travelling waves 优化
Xi Chen,Mohsen Latif,Wiljones Djoutsop et al.
Xi Chen et al.
Ion mobility spectrometry (IMS) is increasingly recognized as a powerful technique in analytical chemistry, enabling the separation of gas-phase ions based on their size-to-charge ratio. Among the most advanced implementations of IMS are th...
Higher-Energy Collisional Dissociation Mass Spectrometry Fragmentation Enables Distinguishing O-GlcNAc from Tn Antigen in Cancer Cells [0.03%]
高能量碰撞解离质谱法鉴别癌细胞中的O-GlcNAc和Tn抗原
Qiushi Chen,Wangzhirui Cheng,Can Li et al.
Qiushi Chen et al.
Protein glycosylation plays essential roles in various biological processes, and thus determining the glycan structure present on the protein is essential to comprehensively understand these events. However, distinguishing saccharide stereo...
Faces of Mass Spectrometry/Khatereh Motamedchaboki [0.03%]
质谱的面孔/ bonus profile Khatereh Motamedchaboki
Anne Brenner,J D Brookbank
Anne Brenner
In-Source Fragmentation of Pyrrolidine-Containing KRAS Scaffolds Leads to Enhanced Structure Elucidation and Tandem Mass Spectral Quality [0.03%]
含吡咯烷的KRAS骨架的内部碎裂可增强结构阐明和串联质谱质量
Jessica L Ochoa,Christopher M Crittenden
Jessica L Ochoa
The characterization of small-molecule therapeutics containing basic moieties, such as pyrrolidine groups common in KRAS G12C inhibitors, presents challenges for structure elucidation via tandem mass spectrometry (MS/MS). During fragmentati...