Biophysical and Raman Spectroscopy assessment of drug-induced photosensitivity: Insights from a randomised controlled pilot study [0.03%]
药物诱导光敏感的生物物理和拉曼光谱评估：随机对照试点研究的新见解
Karolina Anderle,Julia Deinsberger,Pia Hübel et al.
Karolina Anderle et al.
Background: Drug-induced photosensitivity is a recognised adverse reaction, yet systematic quantification remains limited. This study investigates the quantitative impact of commonly prescribed drugs on human skin physiol...
Impact of shelf-life on the pharmaceutical equivalence assessment of a hydrocortisone semisolid W/O emulsion: Evaluation of rheological, structural, and release properties [0.03%]
货架寿命对一种氢化可的松固液分散W/O乳膏剂药物等同性评价的影响：流变学、结构和释放性能的评估
Andreu Mañez-Asensi,Mª Jesús Hernández,Víctor Mangas-Sanjuán et al.
Andreu Mañez-Asensi et al.
Developing generic topical medicines is particularly challenging because of pharmaceutical equivalence criteria at microstructure level. The EMA guideline on bioequivalence of topical products introduced flexibility, acknowledging the high ...
Novel indole-based derivatives as promising NLRP3 Inflammasome Inhibitors: Design, Synthesis, Biological Evaluation, and In Silico Studies [0.03%]
基于吲哚的新一代NLRP3炎性小体抑制剂抑制剂：设计、合成、生物评价及分子对接研究
Simona Di Martino,Maria Rita Giuffrè,Giovanna Li Petri et al.
Simona Di Martino et al.
Seeking to identify a new chemotype for the development of NLRP3 inhibitors, inspired by the structure of the tool compound MCC950 (9), we designed and synthesized new derivatives by choosing the indole heterocycle as spacer between the fur...
Hospital in-use evaluation of the physical, chemical and affinity stability of the antibody-drug conjugate trastuzumab deruxtecan (Enhertu®) [0.03%]
抗体药物偶联物德喜利尤单抗(DS-8201a/Enhertu)在医院使用中的物理、化学及亲和稳定性评估研究
Emmanuel Douez,Nicolas Joubert,Guillaume Gabant et al.
Emmanuel Douez et al.
More and more expensive antineoplastic therapies such as antibody-drug conjugates (ADCs) are being marketed worldwide. To ease the burden on the healthcare system, it is therefore important to optimize their use from preparation to administ...
Structural and functional analysis of OATP and ABCB1-mediated transport of pentamidine analogs: An integrated in vitro and in silico approach [0.03%]
五氨乙烷类似物的OATP和ABCB1介导转运的结构与功能分析：体外及分子建模综合研究方法
Sára Fülöp,Éva Bakos,Paweł Kaźmierczak et al.
Sára Fülöp et al.
Pentamidine is an FDA-approved antiparasitic drug used to treat African trypanosomiasis caused by Trypanosoma brucei, as well as Pneumocystis and Leishmania infections, however, its clinical utility is limited by poor blood-brain barrier pe...
PRGF eye drops mitigate oxidative stress and fibrosis in an in vitro glaucoma model: The role of platelet and plasma enrichment [0.03%]
富含血小板和血浆的PGF眼药水通过体外模型减轻青光眼氧化应激及纤维化：血小板和血浆的作用
Eduardo Anitua,María de la Fuente,Francisco Muruzabal et al.
Eduardo Anitua et al.
Background: Glaucoma, a neurodegenerative disease often linked to elevated intraocular pressure (IOP) and trabecular meshwork (TM) dysfunction, involves oxidative stress and fibrosis. This in vitro study evaluated the imp...
Engineered small extracellular vesicles provide low-dose salidroside delivery to attenuate retinal ganglion cell degeneration [0.03%]
工程化的小细胞外囊泡通过递送低剂量山参素来缓解视网膜神经节细胞的退行性病变
Xue-Ni Peng,Sheng-Jin Xiang,Yue-Xiao Wu et al.
Xue-Ni Peng et al.
Optic neuropathy is characterized by impaired optic nerve function resulting from various pathological processes, often leading to retinal ganglion cell (RGC) degeneration and irreversible vision loss. Several studies have demonstrated the ...
Bridging In Silico Design and Experimental Validation: Virtual Screening and In Vitro Assessment of Biomimetic Anticancer Peptides Inspired by Horseshoe Crab Hemolymph Proteins [0.03%]
从计算机辅助设计到实验验证：模拟筛选并体外评估灵感来源于马蹄蟹血淋巴蛋白的仿生抗肿瘤多肽
Thananya Ratanachotpanich,Aussadech Chumgate,Kanapos Lengwehasathit et al.
Thananya Ratanachotpanich et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, necessitating the development of more selective and safer therapeutic options. Biomimetic peptides derived from natural sources offe...
Early-stage pharmaceutical development of bilayer buccal films with a chitosan backing layer for local pain management in oral mucositis [0.03%]
用于口腔黏膜炎局部止痛的双层口腔粘膜给药薄膜（壳聚糖背衬层）的早期药物开发研究
Karin Korelc,Vishnu Arumughan,Åke Henrik-Klemens et al.
Karin Korelc et al.
Oral mucositis is a painful inflammation and ulceration of the oral mucosa that frequently occurs as a side effect of radiation and chemotherapy that impairs patients' quality of life, making eating and drinking challenging. Local anestheti...
PET/CT imaging of the peptide-based anti-CD47 probe [18F]AlF-NOTA-Pep-20 in preclinical models [0.03%]
基于肽的抗CD47探针[18F]AlF-NOTA-Pep-20的小动物PET/CT显像研究
Guangfa Bao,Ming Tang,Yajie Dong et al.
Guangfa Bao et al.
Cluster of differentiation 47 (CD47), a key immune checkpoint, is significantly overexpressed in tumors and transmits a 'don't eat me' signal that facilitates tumor immune evasion. This study aims to develop a peptide-based positron emissio...