Redox-responsive caveolae-mediated hybrid calcium phosphate nanovectors for the effective gene transfection [0.03%]
红氧化响应的网格蛋白介导的混合钙磷酸纳米载体有效基因转染
Jing-Liang Xu,Xiao-Pei Zhai,Wei Wang et al.
Jing-Liang Xu et al.
The efficient delivery and intracellular release of genes remain a huge challenge for gene therapy. Calcium phosphate (CaP) is a commonly used gene delivery vector, but traditional CaP nanoparticles have poor stability. They are too easy to...
Targeted IL-4 nanoparticles for osteal macrophages modulation in osteoporosis [0.03%]
靶向IL-4纳米颗粒在骨质疏松症中调节破骨细胞巨噬细胞的功能研究
Rebeca Martinez-Borrajo,Pieter A De Beule,Alex Alcoba-Pacheco et al.
Rebeca Martinez-Borrajo et al.
Osteoporosis (OP) is a chronic disease that compromises bone health. It is characterized by a disruption of bone tissue homeostasis, resulting in reduced bone mineral density and an increased risk of fractures. This enhanced fracture risk i...
Development and optimization of an LED-based particle image velocimetry methodology for dynamic powder flowability in pharmaceutical manufacturing [0.03%]
基于LED的粒子图像测速法在药物制造中动态粉体流动性能的研究与优化
Sang Min Lee,Ji Yeon Kim,Du Hyung Choi
Sang Min Lee
Conventional static flowability tests lack the sensitivity to capture process-relevant powder dynamics. This study developed and optimized an LED-based particle image velocimetry (PIV) system for real-time, non-invasive characterization of ...
Contamination of ophthalmic solutions by 2,4-Di‑tert-butylphenol: an evaluation of leachability and in vitro cytotoxicity [0.03%]
关于眼科溶液受2,4-二特丁基苯酚污染的评估：可浸出性和体外细胞毒性试验
Marion Barrieu,Othylie Allard,Lise Bernard et al.
Marion Barrieu et al.
Introduction: Multi-dose ophthalmic devices equipped with complex dropper systems can release substances, such as 2,4-Di‑tert-butylphenol (2,4-DTBP), that could then contaminate the patients. The objectives of this study...
Physiologically-based pharmacokinetic modeling of belimumab for systemic lupus erythematosus patients to predict the withdrawal time in pregnancy and vaccine time in infants [0.03%]
基于生理的药代动力学建模预测贝利木单抗系统性红斑狼疮患者孕期撤药时间和婴儿接种时间
Peilin Zhou,Chenming Zhong,Meng Ke et al.
Peilin Zhou et al.
Belimumab (BEL) is a monoclonal antibody that targets B cell activating factor (BAFF) and has been approved for treating systemic lupus erythematosus (SLE). However, its optimal withdrawal time during pregnancy and the appropriate vaccine t...
Exposure-response modeling of QTc interval and creatine kinase-MB in healthy people and treatment-naïve adults living with HIV-1 treated with ainuovirine monotherapy or combined with lamivudine and tenofovir DF [0.03%]
恩生平单药或与拉米夫定及富马酸替诺福韦二吡osphate联用对健康志愿者和初治HIV-1感染成人QTc间期和肌酸激酶-MB的影响的量效关系模型研究
Ziyue Zhou,Yihang Zhang,Xinming Yun et al.
Ziyue Zhou et al.
Background: Corrected QT (QTc) interval prolongation elevates fatal arrhythmia risk in people living with HIV (PLWH). Ainuovirine (ANV), a novel non-nucleoside reverse transcriptase inhibitor, demonstrates a favorable pre...
Ex vivo diffusion and biodistribution studies of progesterone delivered to the eye using 3D-printed inserts [0.03%]
用于眼部递送黄体酮的3D打印植入物的体外扩散和生物分布研究
Lucía Bernat-Just,Phuong Linh Ta,María Sebastián-Morelló et al.
Lucía Bernat-Just et al.
Three-dimensional (3D) printing has emerged as a powerful technology for the fabrication of personalized drug delivery systems. In this work, we developed and characterised 3D-printed ocular inserts for the sustained delivery of progesteron...
Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma [0.03%]
开发和验证一种半自动免疫捕获液相色谱-质谱法，以量化小鼠血浆中的LALA突变生物药物
Vittoria Papa,Ilse De Salve,Francesco Molinaro et al.
Vittoria Papa et al.
Biotherapeutic antibodies are increasingly being developed and, various strategies have recently been used to maximize their potential therapeutic efficacy. The crystallizable fragment (Fc) region of therapeutic monoclonal antibodies (mAbs)...
A new insight on the potentiometric log P determination of therapeutically important opioids and fluoroquinolones [0.03%]
pH计测定治疗重要药物阿片类和氟喹诺酮类logP的新见解
Alaa Malik,Sándor Hosztafi,Béla Noszál et al.
Alaa Malik et al.
Lipophilicity is a crucial physicochemical property that affects ADME behavior, toxicity, and adverse effects of drugs. It can be quantified in terms of partition coefficients, determined typically in octanol-water dual systems. Reliable de...
Development of inhalable extra-fine particles of vancomycin for the treatment of pulmonary methicillin-resistant Staphylococcus aureus infections [0.03%]
用于治疗肺部耐甲氧西林金黄色葡萄球菌感染的可吸入超细万古霉素粒子的研发
Petra Party,Dilay Göksel,Árpád Farkas et al.
Petra Party et al.
Pulmonary infections caused by Methicillin-resistant Staphylococcus aureus represent a major therapeutic challenge, highlighting the need for efficient local antibiotic delivery. This study aimed to develop an extra-fine dry powder inhaler ...