Is a DoE-based approach superior to OFAT for HPLC robustness assessment under ICH Q14? A practical case study [0.03%]
ICH Q14下基于DoE的方法是否优于OFAT的HPLC鲁棒性评估？一个实际案例研究
Alba Aragón-Navas,Dennis Walter,Melanie Schmidt et al.
Alba Aragón-Navas et al.
Method robustness is a critical aspect of analytical development, particularly in pharmaceutical research. This work investigates whether a Design of Experiments (DoE) approach provides advantages over traditional one-factor-at-a-time (OFAT...
Injectable photo-crosslinked hyaluronic acid/carboxymethyl cellulose hydrogel for the sustained delivery of rhFGF2 and accelerated wound healing [0.03%]
一种用于持续递送rhFGF2和加速伤口愈合的可注射光交联透明质酸/羧甲基纤维素水凝胶
Prasopchai Patrojanasophon,Peerapat Chidchai,Praneet Opanasopit et al.
Prasopchai Patrojanasophon et al.
This study developed a photo-crosslinkable injectable hydrogel combining hyaluronic acid-catechol (HAC) and carboxymethylcellulose-methacrylate (CMCAM) as an advanced wound dressing. HAC and CMCAM were functionalized using carbodiimide reac...
Prognostic Significance and Therapeutic Implications of Migrasome-related genes in Sorafenib Treatment for Primary Liver Cancer [0.03%]
Migrasome相关基因在索拉非尼治疗原发性肝癌中的预后意义和治疗启示
Lei Wang,Zhaoxia Wan,Linlu Gao et al.
Lei Wang et al.
Purpose: This study aimed to reveal the mechanism and prognostic significance of migrasome-related genes (MGs) in primary liver cancer (PLC) treated with Sorafenib (Sor) treatment. ...
A phenothiazine analog, PTF, suppresses breast cancer growth by inhibiting YAP signaling [0.03%]
一种吩噻嗪类似物PTF通过抑制YAP信号抑制乳腺癌生长
Jing-Ru Weng,Li-Yuan Bai,Jing-Lan Hu et al.
Jing-Ru Weng et al.
Phenothiazines, a class of compounds originally developed for the treatment of psychotic disorders, exert antitumor activity by targeting multiple signaling pathways. In this study, we evaluated the anticancer potential of a modified phenot...
Structural and Mechanical Alterations in Polyoxymethylene: Insights from Advanced Irradiation Technologies [0.03%]
高级辐照技术下聚氧化乙烯的结构和机械性能变化研究
Blanche Krieguer,Fabien Girard,Nathalie Dupuy et al.
Blanche Krieguer et al.
The study investigates structural and mechanical changes in polyoxymethylene (POM) resulting from gamma, X-ray, and e-beam irradiation used for sterilization. Techniques such as Electron Spin Resonance (ESR), Differential Scanning Calorimet...
Liposomes and lipid nanoparticles: a tutorial for advanced chemical and structural characterisation [0.03%]
脂质体和脂质纳米颗粒：用于高级化学和结构表征的教程
Caterina Minelli,Jeremie Parot,Enrica Alasonati et al.
Caterina Minelli et al.
Liposomes and lipid nanoparticles (LNPs) are central to modern drug‑delivery strategies, yet their reliable characterisation remains challenging due to their structural complexity and the limited availability of harmonised analytical stand...
Organotypic retinal cultures as an ex vivo screening platform for PLGA-based neuroprotective microspheres [0.03%]
基于PLGA的神经保护微球的组织工程视网膜模型筛选平台研究
Cristina García-Caballero,Cristina Morilla-Lomeña,Marta Vicario-de-la-Torre et al.
Cristina García-Caballero et al.
In this study, the suitability of organotypic cultures of neonatal rat retina as a controlled ex vivo platform for the evaluation of intraocular microparticulate drug delivery systems is assessed, while also exploring their ability to ident...
Oral bioavailability of fenofibrate from melt-extruded phospholipid-containing solid dispersions: A rat study [0.03%]
含有磷脂的熔融共挤出固态分散体中非诺贝特口服吸收：大鼠实验研究
Mikołaj Czajkowski,Filip Otto,Agnieszka Karbownik et al.
Mikołaj Czajkowski et al.
Amorphous solid dispersions (ASDs) are an established strategy to improve the bioavailability of poorly soluble drugs. In this study, we compared the in vivo pharmacokinetics of fenofibrate (FEN) in hot-melt-extruded ternary ASDs containing...
Visualized triglyceride mimetic prodrugs: Preparation, effect evaluation and mechanistic investigation of lymphatic transport [0.03%]
可视化三酰基甘油拟素前药的制备、效果评估及淋巴转运机制研究
Shujing Yan,Liangyun Li,Haiyang Cui et al.
Shujing Yan et al.
Triglyceride-mimetic prodrugs are prepared by conjugating a triglyceride moiety to the parent drug, which promotes lymphatic transport, reduces hepatic first-pass metabolism, and enhances the oral bioavailability of the parent drug. To veri...
Cocrystal mitigates the effects of elevated gastric pH on oral absorption of weakly basic drugs: a case study with ketoconazole-succinic acid cocrystal on beagle dogs [0.03%]
共晶体缓和高胃液pH值对弱碱性药物口服吸收的影响：以小猎犬体内的酮康唑-琥珀酸共晶为例
Yitian Marguerite Tucci,Tatiane Cogo Machado,Duxin Sun et al.
Yitian Marguerite Tucci et al.
It is well documented that weakly basic drugs, such as ketoconazole (KTZ), will exhibit reduced oral absorption and lower bioavailability in elevated gastric pH conditions. Because this occurs frequently in patients taking medicines to redu...