A structure-derived compositional framework for interpreting membrane permeability via relative interaction balance [0.03%]
基于结构的组成框架通过相对相互作用平衡解释膜通透性
Ken Yoshioka
Ken Yoshioka
Membrane permeability is a central determinant of oral drug absorption and underpins the Biopharmaceutics Classification System (BCS), yet its physicochemical interpretation remains challenging when described using conventional structure-ba...
Engineering piroxicam crystals with targeted morphologies and polymorphs using organic additives: A comprehensive study of tablet performance and molecular mechanisms [0.03%]
采用有机添加剂工程设计吡罗昔康晶体形态和多晶型的综合研究：基于片剂性能和分子机制方面
Maoyuan Liu,Xian Sun,Guangyue Li et al.
Maoyuan Liu et al.
Piroxicam is widely employed as a non-steroidal anti-inflammatory drug for the alleviation of inflammation and pain. However, its crystallization process is often accompanied by concomitant polymorphism, which poses challenges for productio...
Determinants of simulated dissolution profile similarity (f2): Interactions of Z-factor, particle size, dose, solubility, and diffusivity [0.03%]
影响模拟溶出曲线相似性(f2)的因素：Z因子、粒径、剂量、溶解度及扩散系数的相互作用
Ayse Nur Oktay,Diego Véliz-Otani,James E Polli
Ayse Nur Oktay
Particle size frequently varies during development and is a common critical material attribute for oral drug products. In this work, we investigated how particle size effects on dissolution similarity depend on dose, intrinsic solubility, a...
Mareike Lutz,Tessa Moleman,Hubert G M Leufkens
Mareike Lutz
The European research landscape for developing new diagnostic, preventive, and therapeutic interventions is fraught with challenges. Scarcity of qualified talent, limited funding for laboratories and research infrastructure, geopolitical co...
Transcript‑activated matrices with optimized mRNA designs to direct chondroblastic lineage commitment [0.03%]
具有优化的mRNA设计的转录激活基质以指导软骨细胞谱系的命运决定
Héctor Rilo-Alvarez,Adriana Martinez-Ledo,Monica Lopez-Pena et al.
Héctor Rilo-Alvarez et al.
New strategies are required to modulate early chondroblastic differentiation in a controlled and transient manner, a key challenge in cartilage tissue engineering. Transcript‑Activated Matrices (TAMs), formed by embedding mRNA within bioma...
Modulation of Remimazolam Placental Transfer via OATP2B1 by Rosuvastatin in an In Vitro 3D Placental Barrier Model [0.03%]
雷米唑胺在体外三维胎盘屏障模型中的转运及其与Rosuvastatin结合OATP2B1的调节作用研究
Satoshi Sato,Tomohiro Chaki,Katsuya Narumi et al.
Satoshi Sato et al.
Fetal exposure to anesthetics via the placenta during the perinatal period may adversely affect central nervous system development. Organic anion-transporting polypeptide 2B1 (OATP2B1) functions as an active transport carrier across the blo...
Impact of porcine skin processing on in vitro permeation testing: implications for reliable evaluation of topical metformin delivery [0.03%]
猪皮处理对体外透皮试验的影响：局部涂抹降糖药渗入皮肤的效果的可靠评价的启示
Celina Zhao,Jianying Zhang,Vasyl Pastukh et al.
Celina Zhao et al.
Porcine ear skin is widely used as a surrogate for human skin in vitro permeation testing (IVPT) due to its structural and physiological similarities. However, variability in tissue sourcing represents a major but underrecognized source of ...
Tofersen in SOD1-associated amyotrophic lateral sclerosis: From molecular mechanisms to regulatory milestones [0.03%]
SOD1相关渐冻症中托芬塞的应用：从分子机制到监管里程碑
Antonio J Braza,Montserrat Viñas-Bastart,Maria Sureda-Rosich et al.
Antonio J Braza et al.
Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive and ultimately fatal neurodegenerative disorder characterized by degeneration of upper and lower motor neurons. Mutations in the superoxide dismutase 1 (SOD...
Preformulation studies of levonorgestrel: A supplier variation analysis [0.03%]
左旋诺孕酯药物研制前期研究：供应商差异分析
Clarice Sombra de Medeiros,Magnus Ipsen Pedersen,Mathias Dam Mønster Sørensen et al.
Clarice Sombra de Medeiros et al.
Levonorgestrel (LNG) is a second-generation synthetic progestogen that has been widely used in oral tablets for emergency contraception, intrauterine devices and transdermal implants. The main objectives of the present work were to evaluate...
Optimizing Post-printing Drying Conditions for Point-of-Care Manufacturing of SSE-3D Printed Medicines [0.03%]
用于SSE-3D打印药物的即时制造的后处理干燥条件优化
Javier Suárez-González,María M Rodríguez-Linares,Mabel Soriano et al.
Javier Suárez-González et al.
Post-printing drying conditions could affect the quality of oral use printlets elaborated by semi-solid extrusion (SSE) 3D printing, yet their systematic characterization as Critical Process Parameters (CPPs) remains limited. This study eva...