3D Printed Intrauterine Device Development Containing Dual Anticancer Drugs for The Treatment of Uterine Cancer [0.03%]
用于治疗子宫癌的含双重抗癌药物的3D打印宫内装置的研发
Cem Varan,Davut Aksüt,Murat Şen et al.
Cem Varan et al.
Uterine cancer is a major global health problem and treatment frequently includes invasive surgery that severely compromises fertility. Current systemic chemotherapeutic drugs, such as paclitaxel (PCX) and carboplatin (CBP), lack an establi...
Identification of Pyrrolo[2,3-d]pyrimidine-Based Dual MERTK and FLT3 Inhibitor: Hit-to-Lead, Machine Learning, Modeling, Synthesis, and Biological Evaluation [0.03%]
基于吡咯并[2,3-d]嘧啶的双MERTK和FLT3抑制剂的鉴定：从苗头化合物到先导物、机器学习、建模、合成及生物活性评价
Abdellah Yamani,Paweł Maliszewski,Natalia Piórkowska et al.
Abdellah Yamani et al.
Overexpression of MERTK and FLT3 plays a crucial role in activating signal transduction pathways in various human hematological malignancies. These signaling pathways have been extensively studied and have shown significant potential as a p...
Holistic evaluation of particle formation induced by physical stress in liquid peptide solutions [0.03%]
物理应力诱导液相多肽溶液中颗粒生成的全流程评估
Patrick Schlossbauer,Stefanie Schopf,Katrin Lindner et al.
Patrick Schlossbauer et al.
Insufficient physical stability remains a major challenge regarding the development of liquid therapeutics as aggregation and degradation of the drug substance can lead to patient safety concerns through increased immunogenicity or reduced ...
Calcitriol-mediated modulation of organic anion transporters: Insights from endogenous biomarkers and methotrexate pharmacokinetics [0.03%]
骨化三醇介导的有机阴离子转运蛋白调节：来自内源性生物标志物和甲氨蝶呤药代动力学的见解
Dang-Khoa Vo,Thi-Thao-Linh Nguyen,Seul-A Joo et al.
Dang-Khoa Vo et al.
This study aimed to investigate the effects of calcitriol on endogenous biomarkers taurine and pyridoxic acid (PDA) associated with the organic anion transporters Oat1 and Oat1/3, respectively, and compare these changes with those observed ...
Scoping Review to Identify Data Needs and Environmental Hotspots for Future LCA Studies: Insights into Pharmaceutical Excipients and Processes [0.03%]
识别未来LCA研究的数据需求和环境热点的综述性回顾——关于药用辅料和工艺的见解
Anja Autzen Virtanen,Satu Lakio,Atif Madi et al.
Anja Autzen Virtanen et al.
In recent years, the environmental assessment and optimization of pharmaceutical dosage forms have received increasing attention. Consequently, interest in Life Cycle Assessments (LCA) has grown, and LCA is rapidly becoming the standard met...
Corrigendum to "Novel porphyrin photosensitizer LD4-PDT alleviates asthma airway remodeling by inhibiting EGR1-dependent TGF-β1/Smad signaling" [European Journal of Pharmaceutical Sciences, Volume 218 (2026) 107431] [0.03%]
关于“新型卟啉光敏剂LD4-PDT通过抑制EGR1依赖性TGF-β1/Smad信号通路缓解哮喘气道重塑”的勘误(欧洲药学科学杂志，第218卷(2026) 107431)
Zhuo Tao,Hongzhi Yu,Bin Xu et al.
Zhuo Tao et al.
Revealing the Morphology of Small Multilamellar Lipid Nanoparticles (SMLPs) made by In-Vial Homogenization [0.03%]
瓶内均质法制备的小型多层脂质纳米颗粒(SMLP)的形态学研究
Sevda Akcesme,Stefanie Schmager,Yassir Al-Tikriti et al.
Sevda Akcesme et al.
Previous research shows that thermosensitive small multilamellar lipid nanoparticles (tSMLPs) offer promising features for temperature-triggered cytostatic drug delivery, remaining completely stable at body temperature (37°C) and releasing...
Construction of in situ temperature-sensitive gel of Tegafur derivative TAK5399 and its evaluation against breast cancer [0.03%]
他莫西芬衍生物TAK5399原位敏感温凝胶的制备及抗乳腺癌评价
Hong Shao,Wen Li,Zhuohan Li et al.
Hong Shao et al.
Tegafur (FT) is widely used in the treatment of breast cancer. However, it has poor efficacy and significant toxic side effects. In this study, we first modified FT with aspirin to obtain a new FT derivative, named TAK5399. Then, TAK5399 in...
Design of Co-lyophilised Ternary Insulin-Sucrose-Polymer Systems with Enhanced Amorphous Glass stability [0.03%]
设计具有增强无定形玻璃稳定性的协同冻干三元胰岛素-蔗糖-聚合物体系
Claudia Giannachi,Evin Allen,Sonja Vucen et al.
Claudia Giannachi et al.
The glass stability of lyophilized amorphous peptide formulations, intended for incorporation into solid oral dosage forms, require stabilisation against the challenges of manufacturing, storage and handling temperature and humidity. High g...
Minimizing Aggregates when Nebulizing Antibody Fab Fragments: High Thermostability and High Concentration are Key [0.03%]
雾化抗体Fab片段时最小化聚集：高热稳定性及高浓度是关键
Josi Ann Steinke,Pierre-Louis Destruel,Benjamin Weiche et al.
Josi Ann Steinke et al.
The therapeutic potential of inhaled biologics is limited by protein instability during aerosolization, which can cause aggregation and increase immunogenicity risks. This study aims to identify key molecular and formulation parameters that...