Cytotoxic crosslinker-loaded indocyanine green nanoparticle for near-infrared fluorescence imaging-guided chemo-photothermal eradication of triple-negative breast cancer [0.03%]
用于三阴性乳腺癌近红外荧光成像引导的化疗和光热治疗的载有细胞毒性交联剂的吲哚菁绿纳米粒子
Yanan Li,Zijun Qiu,Juan Yu et al.
Yanan Li et al.
Crosslinkers are conventionally used for cell fixation due to their crosslinking ability, although they are cytotoxic. Given this cytotoxicity, their therapeutic potential as anticancer agents remains largely unexplored. Herein, we repurpos...
Ethnopharmacobotanical investigation of plants used for respiratory disorders in Transylvania, Romania [0.03%]
罗马尼亚特兰西瓦尼亚地区植物药用资源调查研究（用于治疗呼吸系统疾病）
Nóra Papp,Rita Filep,Dóra Czégényi et al.
Nóra Papp et al.
Introduction: Respiratory disorders remain a significant public‑health concern across Europe, and traditional ethnomedical knowledge continues to play an important role in several Transylvanian communities. This study ai...
The Effect of pH Stability and Aqueous Solubility on the Oral Bioavailability of A Novel Antileishmanial Agent [0.03%]
一种新型抗利什曼病药物的口服生物利用度受pH稳定性和水溶性的影响
Maria Rincon Nigro,Tolulope Adebusuyi,Manvir Kaur et al.
Maria Rincon Nigro et al.
OJT007 is a novel drug class with potent antiproliferative effects against Leishmania Major. The drug is amphoteric with a key basic amine pKa of 5.8 and acid liable. Pre-systemic metabolism in gastric acidic compartment is suspected as a m...
Karin Kogermann,Ivo Laidmäe,Andrea Heinz et al.
Karin Kogermann et al.
Redox-responsive oral drug delivery systems for inflammatory bowel disease: Analytical challenges, design strategies, and translational outlook [0.03%]
用于炎症性肠病的氧化还原响应口服给药系统：分析挑战、设计策略和转化前景
Bhargav Mahabaleshwara Hegde,Rashmi N G
Bhargav Mahabaleshwara Hegde
Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory illness, kind a thing that involves immune dysregulation, a weakened epithelial barrier, microbiota alterations, genetic susceptibility, and of course environmental i...
Impact of Gamma Irradiation and Ethylene Oxide Sterilisation on the Stability of Crystalline and Amorphous Drug Solids [0.03%]
γ射线和环氧乙烷灭菌对药物晶体和无定形固体稳定性的的影响
Mohamed Elkhashab,Ziad Sartawi,Denis Lynch et al.
Mohamed Elkhashab et al.
Terminal sterilisation is a critical process for pharmaceutical products intended for parenteral or invasive administration, yet conventional sterilisation approaches can compromise thermolabile or chemically sensitive drug substances. In t...
Metabolic fate and oral dosing feasibility of the formyl peptide receptor 2 agonist WKYMVm: An integrated analytical and kinetic modeling approach [0.03%]
表征并预测WKYMVm的代谢产物及其口服给药生物利用度的研究
Seongsoo Lee,Seungah Yang,Wonseok Hu et al.
Seongsoo Lee et al.
Peptide-based drug candidates are often susceptible to enzymatic degradation in the gastrointestinal environment and biological matrices, while exhibiting limited intestinal permeability. In developing strategies to overcome these limitatio...
Structure and Process Relationships in Extruded Polymer Systems: Solid-State Remodeling of Oxymetazoline [0.03%]
挤压聚合物体系的结构和过程关系：羟甲唑林的固态重塑
Ana Luiza Lima,Guilherme M Gelfuso,Tais Gratieri et al.
Ana Luiza Lima et al.
Hot-melt extrusion (HME) is widely used in the development of drug-polymer systems, yet conventional preformulation approaches remain largely based on equilibrium conditions and may fail to predict material behavior under processing. In thi...
H₂O₂-Induced Oxidative Stress Modulates Methotrexate and Dexamethasone-Dependent Regulation of NLRP3-Associated Transcription and HLA Class I Expression in Primary Human RPE Cells [0.03%]
双氧水诱导的氧化应激调节甲氨蝶呤和地塞米松依赖性调控NLRP3相关转录及人原代视网膜色素上皮细胞I类HLA表达
Zahra Souri,Mohammad Malekahmadi
Zahra Souri
Purpose: Oxidative stress-driven inflammation is a central mechanism in retinal diseases. This study investigated how methotrexate (MTX) and dexamethasone (DEX), alone or in combination, modulate NLRP3-related gene expres...
Synergistic impact of 3D multicellular architecture and capillary-like flow on intestinal drug permeability [0.03%]
三维多细胞结构和毛细血管样流动对肠道药物通透性协同影响
Sofia Dias,Sofia Costa,Sofia Barros et al.
Sofia Dias et al.
Understanding intestinal drug permeability requires in vitro systems capable of reproducing both the structural complexity and the dynamic fluidic environment of the human gut. Traditional two‑dimensional (2D) models, although widely used ...