Lipid nanoparticles for Cas9 ribonucleoprotein delivery: design and evaluation of ionisable oligoamine-lipidoids [0.03%]
阳离子寡胺类脂质样分子的设计及Cas9核糖核蛋白载体LNPs的筛选与评估研究
Maria Lummerstorfer,Zian Xue,Daniel Zheng et al.
Maria Lummerstorfer et al.
Lipid nanoparticles (LNPs) are the most advanced RNA delivery technology and are used with CRISPR-RNA in multiple clinical in vivo genome editing trials. By contrast, systemic delivery of Cas9 ribonucleoproteins (RNPs) - despite their high ...
Synthesis and biological evaluation of novel carbazole derivatives as broad-spectrum antibacterial agents to fight antimicrobial resistance (AMR) [0.03%]
新型卡巴唑衍生物的合成及生物学评价作为广谱抗菌剂对抗抗生素耐药性（AMR）
Maria Grazia Martina,Francesca Barbieri,Sacha Michèle Idriss Cancade et al.
Maria Grazia Martina et al.
The escalation of antimicrobial resistance, especially among ESKAPE pathogens, calls for new antibacterial agents with improved effectiveness against bacteria often causing difficult-to-treat infections. In this work, two sets of carbazole ...
Rheological Modeling and Torque-Based Processability Prediction for Celecoxib/PVPVA Hot-Melt Extruded Amorphous Solid Dispersions [0.03%]
塞来昔布/聚维酮乙烯醇共聚物热熔挤出无定形固体分散体的流变学建模及扭矩法加工工艺预测研究
Paula Kaufelde,Rita Maria Soares,Oxana Brante et al.
Paula Kaufelde et al.
Predicting the processability of amorphous solid dispersions (ASDs) during hot-melt extrusion (HME) remains critical in pharmaceutical development. This study demonstrates that melt apparent viscosity data obtained from rotational rheology,...
Design, synthesis, and biological analysis of aurein 1.2 analogues incorporating fluorinated phenylalanine [0.03%]
含氟苯丙氨酸修饰的 aurein 1.2 类肽的设计、合成及生物活性分析
Nora Angelova,Ivan Iliev,Arianna Rossi et al.
Nora Angelova et al.
Antimicrobial peptides (AMPs) have emerged as a promising therapeutic scaffold for combating antibiotic-resistant infections and cancer. Aurein 1.2, the most studied peptide in the aurein family, displays a broad spectrum of bi-functionalit...
Corrigendum to "Early-stage pharmaceutical development of bilayer buccal films with a chitosan backing layer for local pain management in oral mucositis" [European Journal of Pharmaceutical Sciences 221 (2026) 107530] [0.03%]
关于“用于口腔黏膜炎局部镇痛的双层颊膜制剂早期药物开发”的勘误(欧洲药学科学杂志第221期(2026)[107530])
Karin Korelc,Vishnu Arumughan,Åke Henrik-Klemens et al.
Karin Korelc et al.
Mirtazapine identified as a preventive agent against cisplatin-induced nephrotoxicity: Integrating in silico, in vitro, and in vivo analyses [0.03%]
米塔扎平被确认为预防顺铂引起的肾毒性的药物：结合计算机模拟、体外和体内分析的结果
Ayaka Hase,Kenji Ikemura,Manami Ueno et al.
Ayaka Hase et al.
Cisplatin (CDDP), a platinum-based chemotherapeutic agent, is highly effective in the treatment of various solid tumors. However, CDDP-induced nephrotoxicity (CIN) remains a critical dose-limiting toxicity that compromises CDDP's therapeuti...
Corrigendum to "Pulmonary Delivery of siRNA Lipoplexes and Lipid Nanoparticles using a Vibrating Mesh Nebuliser" [European Journal of Pharmaceutical Sciences 107386 216(2026)] [0.03%]
关于“使用振动网式雾化器将siRNA脂质复合物和脂质纳米颗粒递送至肺部”一文的勘误(206卷2026页（e107386）)
Michael T Neary,Lianne M Mulder,Ciaran O Leime et al.
Michael T Neary et al.
Selective Nanomolar Inhibitors of Carbonic Anhydrases IX and XII: Coumarin Aminophosphonates as Potential Anticancer Agents [0.03%]
选择性纳摩尔抑制剂的碳酸酐酶IX和XII：香豆素氨基磷酸盐作为潜在的抗癌症制剂
Manuela Voráčová,Elena Andreucci,Lucia Magnelli et al.
Manuela Voráčová et al.
Tumor-associated carbonic anhydrases IX and XII are validated targets for cancer therapy. Here we report the first exploration of coumarin aminophosphonates as inhibitors of these isoforms. Using a straightforward Kabachnik-Fields approach ...
Quantitative image analysis reveals the benefits of dapagliflozin on glomerulosclerosis, podocyte effacement and kidney fibrosis in the SDT fatty rat model of diabetic nephropathy [0.03%]
定量图像分析揭示了达格列净对SDT脂肪大鼠糖尿病肾病模型系膜增生、足细胞耗竭和肾脏纤维化的改善作用
François Briand,Estelle Grasset,Masami Shinohara et al.
François Briand et al.
We aimed to optimize drug efficacy studies in the Spontaneously Diabetic Torii (SDT) fatty rat, a type 2 diabetic model, using kidney histology image analysis with 1) quantitative glomerulosclerosis and tubular impairments (Nephropath AI), ...
Targeted polymeric nanoparticles enable epithelial translocation of PROTACs and preserve intracellular protein degradation activity [0.03%]
靶向聚合物纳米颗粒可使PROTACS穿过上皮细胞并保持其在细胞内的蛋白质降解作用
Sarah Vogel-Kindgen,Jonas Schreiner,Fabian Klos et al.
Sarah Vogel-Kindgen et al.
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality for the degradation of disease-associated proteins. Despite their high therapeutic potential, their clinical translation is limited by poor membrane permeability ...