Phylloroseobilin Impairs Tumor Cell Migration and Vascular Network Stability via Cytoskeletal Destabilization [0.03%]
叶玫瑰素通过细胞骨架解聚破坏肿瘤细胞迁移和血管网络稳定性
Cornelia A Karg,Daniel Rüdiger,Fabian Hammerle et al.
Cornelia A Karg et al.
Phyllobilins (PBs) are linear tetrapyrroles and represent the only known bilin family originating from chlorophyll rather than heme. Although colorless phylloleucobilins have long been regarded as the predominant chlorophyll metabolites, re...
AdipoRon ameliorates synovial inflammatory lesions and joint destruction in experimental arthritis by downregulating KRT7 [0.03%]
通过下调KRT7改善实验性关节炎的滑膜炎症病变和关节破坏的AdipoRon疗法
Chen Jiang,Wei Zhang,Hanmei Ren et al.
Chen Jiang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, for which effective therapeutic strategies remain limited. AdipoRon, a synthetic adiponectin receptor agonist, has been reported to...
Discovery of a novel miconazole analogue as a dual apo-IDO1 inhibitor and ABCB1 modulator for cancer immunotherapy and chemosensitizing [0.03%]
一种新型咪康唑类似物作为抗癌免疫治疗和增敏化疗的新型阿泊奥朵卡因为及ABCB1调节剂的发现
Pin-Chen Chen,Yung-Chieh Chang,Yun-Yun Ho et al.
Pin-Chen Chen et al.
Indoleamine 2,3-dioxygenase 1 (IDO1) facilitates tumoral immune evasion via the kynurenine (Kyn) pathway, while ABCB1-mediated efflux drives multidrug resistance. Previously, miconazoles were reported as potent IDO1 inhibitors and some azol...
Identification of an NNK-Associated Gene Signature and Tumor Microenvironmental Features in Head and Neck Squamous Cell Carcinoma [0.03%]
头颈鳞状细胞癌中NNK相关基因特征及肿瘤微环境的鉴定
ZiWei Dai,Junqi Su,Xiaofeng Shan et al.
ZiWei Dai et al.
Background: Tobacco exposure is a major risk factor for head and neck squamous cell carcinoma (HNSCC), and the tobacco-specific nitrosamine NNK is an established carcinogen. However, the molecular features linking NNK-ass...
Antisolvent crystallization of indomethacin cocrystals: influence of coformers and solvent systems [0.03%]
吲哚美辛共晶的反溶剂结晶：助形式和溶剂系统的影响
Hugo Pardo,Víctor Guarnizo-Herrero,Borja Martínez-Alonso et al.
Hugo Pardo et al.
Indomethacin (IND), a Biopharmaceutics Classification System (BCS) Class II drug, exhibits poor aqueous solubility and low dissolution rate, which may limit its oral absorption. In this study, IND cocrystals with benzoic acid (AcBz), theoph...
Design and Process Parameter Evaluation of Bilayer Capsule Systems for Targeted Ileal Drug Delivery [0.03%]
靶向药物释放的双层微丸制剂及工艺参数评估研究
Elisa Millet,Sofie S T Vandenbroucke,Joseph P O&#x;Shea et al.
Elisa Millet et al.
The dynamic and transitory nature of the distal small intestine makes targeted drug delivery to this region particularly challenging. This study aimed to develop a bilayer capsule system for site-specific drug release in the terminal ileum....
iRGD-Modified Peptide-Drug Conjugate Improves Brain Delivery and Antitumor Efficacy in Glioblastoma [0.03%]
iRGD修饰的肽药物偶联物可提高其治疗胶质母细胞瘤时的脑部递送和抗肿瘤功效
Danyang Yun,Lizhen Mu,Juan Liu et al.
Danyang Yun et al.
Glioblastoma (GBM) remains the most aggressive primary brain tumor, with poor prognosis largely due to limited drug delivery across the blood-brain barrier (BBB) and insufficient intratumoral penetration. To address these challenges, we dev...
A Δ‑Based Framework For Internal Release Limits In Plateau Stability Systems [0.03%]
基于Δ的高原稳定性系统内部释放限制框架
Thanh N Tran
Thanh N Tran
Internal Release Limits (IRLs) in pharmaceutical manufacturing are commonly derived using statistical tools originally developed for shelf‑life assignment, most notably time‑series regression and kinetic extrapolation. While appropriate f...
Innovative Peptide Formulations for Cardiovascular Diseases Using Supercritical CO2: A Comprehensive Review and Potential Applications [0.03%]
超critical CO2在心血管疾病肽类创新制剂中的应用研究综述及潜在价值探讨
Silvio A B Vieira de Melo,Elaine C M C Albuquerque,Ravenna L Matos et al.
Silvio A B Vieira de Melo et al.
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, creating an urgent need for novel therapeutic strategies and advanced manufacturing processes that are scalable and cost-effective. Peptide-based ...
An injectable nanoreinforced hydrogel for combined GDNF-loaded nanoparticles and mesenchymal stem cell therapy in Parkinson's disease [0.03%]
一种可注射的纳米增强型水凝胶，用于帕金森病的GDNF载药纳米颗粒和间充质干细胞联合治疗
Rubén Del Campo-Montoya,Xavier Mulet I Piera,Marta García-Gómara et al.
Rubén Del Campo-Montoya et al.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, and no current treatment can halt neurodegeneration or restore the nigrostriatal pathway. Although glial cell l...