Evaluation of transduction properties and vaccine efficacy of a simian adenovirus type 25-based vector [0.03%]
评估猿腺病毒25型载体的转导特性及疫苗效力
Fuka Okumura,Sora Tokuoka,Naoya Nagata et al.
Fuka Okumura et al.
Although human adenovirus serotype 5 (Ad5) is widely used as a vaccine vector for infectious diseases due to its high transduction efficiency, pre-existing immunity to Ad5 in many people reduces vaccine efficacy. To address this limitation,...
Toward individualized precision dosing of perampanel: Integrating therapeutic drug monitoring, drug-drug interactions, and pharmacogenetics [0.03%]
以个体化精准给药为导向的帕利哌酮临床药物治疗：治疗药物监测、药物相互作用及药物基因组学整合分析展望
Hong-Li Guo,Yang-Yang Xu,Yue Li et al.
Hong-Li Guo et al.
Perampanel (PER), the first high-selectivity, non-competitive AMPA-type glutamate receptor antagonist approved for clinical use, plays a pivotal role in the management of drug-resistant epilepsy. However, its clinical application faces sign...
LARS Inhibition Overcomes Regorafenib Resistance in Hepatocellular Carcinoma via Ferroptosis and Drug Metabolism [0.03%]
LARS抑制通过铁死亡和药物代谢克服regorafenib对肝细胞癌的耐药性
Tung-Yao Tsai,Hsuan-Hwai Lin,Yi-Chiao Cheng et al.
Tung-Yao Tsai et al.
Background: Regorafenib improves outcomes in advanced hepatocellular carcinoma (HCC), but acquired resistance limits its durable therapeutic benefit. The metabolic and redox mechanisms driving regorafenib resistance remai...
Deep Learning-Based Prediction of Drug Bitterness Using Molecular Structures [0.03%]
基于深度学习的药物苦味分子结构预测
Hiroaki Iwata,Soyoka Tanihata,Shin-Ichi Fujiwara
Hiroaki Iwata
Bitterness is a major cause of poor medication adherence, particularly in pediatric patients. Although several machine learning models have been developed for bitterness prediction, most rely on single-task learning and have undergone limit...
Inhaled product dissolution as a predictive tool of drug bioavailability: a p38 MAPK inhibitor case study using Respicell® dissolution apparatus [0.03%]
一种预测吸入产品生物利用度的工具：应用Respicell公司溶解装置对p38 MAPK抑制剂进行案例分析
Virginia Patterlini,Giulia Marenghi,Alessandro Fioni et al.
Virginia Patterlini et al.
The inhaled p38 α/β mitogen-activated protein kinase inhibitor PF-03715455 is an example of "inhalation by design" pharmacologically active substance which maximize pulmonary residence and local efficacy, demonstrating a slow absorption r...
Comparative pharmacokinetics and tendon tissue targeting of topical metformin lotion with protection against experimental tendinopathy [0.03%]
局部外用瑞舒伐他汀乳膏的组织分布及对跟腱的作用研究
Jianying Zhang,Vasyl Pastukh,Celina Zhao et al.
Jianying Zhang et al.
Effective delivery of therapeutics to tendon tissues remains challenging because conventional systemic administration often fails to achieve sufficient local drug concentrations while increasing off-target exposure. To address this limitati...
Localized In-Situ Nanomedicine Synthesis Enables Copper-Mediated Cuproptosis for Effective Bladder Cancer Therapy [0.03%]
局部原位纳米药物合成可利用铜介导的铜死效应有效治疗膀胱癌
Irfan Mehmud,Lei Peng,Yi Zhang et al.
Irfan Mehmud et al.
Nanomedicine based approaches offer new prospects for cancer treatment by enabling localized delivery, improved tissue retention, and microenvironment response therapeutic activation. Bladder cancer remains challenging due to high recurrenc...
PLCG1 and RAC1 Orchestrate Adaptive Cellular Programs Driving Osimertinib-Tolerant Persister Cell Formation in Malignant Pleural Effusion-Associated Non-Small Cell Lung Cancer [0.03%]
PLCG1和RAC1通过调控适应性细胞程序驱动恶性胸腔积液相关非小细胞肺癌中奥希替尼耐受持久癌细胞的形成
Tung-Yu Tiong,Chieh-Yung Wang,Ying Chen et al.
Tung-Yu Tiong et al.
Acquired resistance to epidermal growth factor receptor (EGFR)-targeted therapies remain a major challenge in non-small cell lung cancer (NSCLC), particularly in patients with malignant pleural effusion (MPE). The MPE microenvironment, char...
Physics-Informed LSTM Neural Network for Personalized Pharmacokinetic Modeling of Polymyxin B in Critically Ill Patients [0.03%]
基于物理知识的LSTM神经网络在重症患者多黏菌素B药动学个性化预测中的应用
Pan Ma,Xin Zhang,Qin Xiao et al.
Pan Ma et al.
Polymyxin B represents a critical last-resort antibiotic for carbapenem-resistant Gram-negative infections, yet its narrow therapeutic window and substantial inter-individual pharmacokinetic variability present significant challenges for op...
A multivariate ANN-CCD integrative model using cellulose based polymers for the development of osmotically controlled push-pull dexibuprofen tablets and its predictive pharmacokinetic modeling [0.03%]
基于纤维素的多变量ANN-CCD集成模型用于开发渗透控制式去异丁苯普鲁卡因片及其预测药代动力学模型
Nazish Mumtaz,Rabia Ismail Yousuf,Muhammad Harris Shoaib et al.
Nazish Mumtaz et al.
The biocompatible macromolecules play a pivotal role in enhancing the performance of various drug delivery systems. In the current work, cellulose acetate (Opadry® CA), microcrystalline cellulose and an intrinsically uncharged polymer, pol...