In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices [0.03%]
药物载三维聚meric矩阵中纳米粒子的原位形成
Felipe Q Pires,Idejan P Gross,Livia L Sa-Barreto et al.
Felipe Q Pires et al.
The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming inc...
Extending the limitations in the prediction of PAMPA permeability with machine learning algorithms [0.03%]
利用机器学习算法预测PAMPA渗透性的局限性及其改进方法研究
Anita Rácz,Anna Vincze,Balázs Volk et al.
Anita Rácz et al.
Gastrointestinal absorption is a key factor amongst the ADME-related (absorption, distribution, metabolism and excretion) pharmacokinetic properties; therefore, it has a major role in drug discovery and drug safety determinations. The Paral...
Nanoparticles-based therapeutics for the management of bacterial infections: A special emphasis on FDA approved products and clinical trials [0.03%]
基于纳米颗粒的抗菌感染治疗药物：特别关注FDA批准产品和临床试验研究进展
Fatemeh Aflakian,Farshad Mirzavi,Hammed Tanimowo Aiyelabegan et al.
Fatemeh Aflakian et al.
Microbial resistance has increased in recent decades as a result of the extensive and indiscriminate use of antibiotics. The World Health Organization listed antimicrobial resistance as one of ten major global public health threats in 2021....
Rethinking of TEER measurement reporting for epithelial cells grown on permeable inserts [0.03%]
关于透析膜上生长的上皮细胞TEER测定报告的再思考
Bedia Begum Karakocak,Sandeep Keshavan,Gowsinth Gunasingam et al.
Bedia Begum Karakocak et al.
Transepithelial electrical resistance (TEER) measures electrical resistance across epithelial tissue barriers involving confluent layer(s) of cells. TEER values act as a prerequisite for determining the barrier integrity of cells, which pla...
Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities [0.03%]
以抗生素为重点管理药物引起的肠道菌群失调的临床影响：挑战与机遇
Lea Gnatzy,George Ismailos,Maria Vertzoni et al.
Lea Gnatzy et al.
The term "intestinal dysbiosis" is used for indicating change(s) of the intestinal microbiota which have been associated with the development of diseases and the deterioration of disease treatments in humans. In this review, documented clin...
Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis [0.03%]
透明质酸包被的制霉菌素载药纳米颗粒治疗念珠菌性阴道炎
Aniely Dos Reis Teixeira,Amanda De Vasconcelos Quaresma,Renata Tupinambá Branquinho et al.
Aniely Dos Reis Teixeira et al.
Miconazole-loaded nanoparticles coated with hyaluronic acid (miconazole-loaded nanoparticles/HA) were developed to overcome the limitations of the conventional therapy of the vulvovaginal candidiasis (VVC). They were synthesized by emulsifi...
Anlotinib and fruquintinib co-administrated with warfarin increases the risk of bleeding: Studied from pharmacokinetic and pharmacodynamic perspectives [0.03%]
安罗替尼与呋喹替尼联用华法林会增加出血风险：基于药代动力学和药效学角度的研究
Boyu Fang,Shasha Jin,Wandi Du et al.
Boyu Fang et al.
Background: Recent studies have reported a higher risk of bleeding among patients that are co-administrated with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) and anticoagulant, which...
Prediction of plasma trough concentration of voriconazole in adult patients using machine learning [0.03%]
机器学习预测成人患者伏立康唑谷浓度分布
Lin Cheng,Yue Zhao,Zaiming Liang et al.
Lin Cheng et al.
Objective: Plasma trough concentration of voriconazole (VCZ) was associated with its toxicity and efficacy. However, the nonlinear pharmacokinetic characteristics of VCZ make it difficult to determine the relationship bet...
Preparation and evaluation of sustained release pirfenidone-loaded microsphere dry powder inhalation for treatment of idiopathic pulmonary fibrosis [0.03%]
用于特发性肺纤维化治疗的吡非尼酮载药微球干粉吸入剂的制备及评价
Shixue Bao,Yi Zou,Caleb Kesse Firempong et al.
Shixue Bao et al.
Pirfenidone (PFND) is a recommended oral drug used to treat idiopathic pulmonary fibrosis, but have low bioavailability and high hepatotoxicity. The study, therefore, seeks to improve the therapeutic activities of the drug via increased bio...
Potent antibacterial activity in surgical wounds with local administration of D-PLEX100 [0.03%]
外用D-PLEX100治疗手术切口感染具有强力的抗菌活性
Noam Emanuel,Goldi A Kozloski,Shlomo Nedvetzki et al.
Noam Emanuel et al.
Despite significant advances in infection control guidelines and practices, surgical site infections remain a substantial cause of morbidity, prolonged hospitalization, and mortality. The most effective component of SSI reduction strategies...