Pulmonary Fibrosis and the TGF-β Signaling Axis: Advances in Targeted Therapeutics [0.03%]
肺纤维化与TGF-β信号轴：靶向治疗的进展
Ying Wang,Yixin Xu,Yan Zhang et al.
Ying Wang et al.
Pulmonary fibrosis (PF) is a chronic progressive lung disease characterised by interstitial inflammation and abnormal repair, which is a multi-step pathological process with few available therapies. The transforming growth factor-β (TGF-β...
Canagliflozin improves early-stage cardiac hypertrophy and energy metabolism in TAC mice [0.03%]
卡那列净可通过改善TAC小鼠早期心脏肥大及心肌能量代谢发挥心脏保护作用
Yumei Luo,Wanlin Peng,Cen Su et al.
Yumei Luo et al.
Early intervention in cardiac hypertrophy helps delay heart failure, but optimal intervention strategies remain unclear. We previously showed that cardiac energy metabolism changes dynamically during early cardiac hypertrophy. As a sodium-g...
Tumor expression of CGRP confers sensitivity to growth inhibition by the anti-CGRP antibody fremanezumab [0.03%]
肿瘤表达的CGRP使细胞增殖抑制于抗CGRP抗体弗马佐单抗敏感化
Daniela Buonvicino,Alessandra Pistolesi,Andrea Lapucci et al.
Daniela Buonvicino et al.
Calcitonin gene related peptide (CGRP) is a neuropeptide exerting key neuromodulatory, vasoactive and immune functions within the periphery and central nervous system. Drugs targeting CGRP such as anti-CGRP mAbs or small molecule CGRP recep...
Characteristics Three waves of pyripyropene fungal alkaloids and synthetic derivatives targeting ACAT2 as insecticides, anti-atherosclerosis and anticancer agents [0.03%]
三波吡啶胡椒烯类真菌生物碱及其针对ACAT2的合成衍生物作为杀虫剂、抗动脉粥样硬化和抗癌剂的特性研究
Christian Bailly
Christian Bailly
The pyripyropenes A-X represent a family of 24 alkaloids isolated from fungi, mainly Aspergillus and Penicillium species, over the past 30 years. Numerous analogues have been isolated from fungi or (hemi)synthesized to investigate structure...
Natural products in lymphoma therapy: Integrating mechanisms, tumor microenvironment modulation, and translational challenges [0.03%]
天然产物在淋巴瘤治疗中的作用：整合机制、肿瘤微环境调节和转化挑战
Hangfan Lin,Chunyi Lyu,Teng Wang et al.
Hangfan Lin et al.
Lymphoma is a heterogeneous group of malignant neoplasms originating from the lymphohematopoietic system, with relapse, drug resistance, and treatment-related toxicity remaining major clinical challenges. Owing to their structural diversity...
SC79 exerts neuroprotective effects in the model of experimental intracerebral hemorrhage [0.03%]
SC79在实验性脑出血模型中的神经保护作用
Xuehan Zhuang,Min Fang,Bo Feng et al.
Xuehan Zhuang et al.
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, yet specific treatments with conclusive clinical benefit remain lacking. The protein kinase B (AKT) signaling pathway is essential to various cellular functions in st...
A triazole-derived compound mitigates behavioral, biochemical, and molecular alterations in a chronic stress-induced depression model [0.03%]
一种咪唑衍生物通过行为生化和分子改变减轻慢性压力诱导的抑郁模型中的症状
Marcelo Heinemann Presa,Marcia Juciele da Rocha,Kauane Nayara Bahr Ledebuhr et al.
Marcelo Heinemann Presa et al.
The increase in psychiatric disorders such as depression, largely associated with chronic stress exposure, highlights the need for safer and more effective therapeutic strategies. Compounds containing the triazole ring, such as 1-(2-(4-(4-e...
S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis [0.03%]
人源化S14G-humanin（HNG）通过抑制Z-DNA/ZBP1介导的坏死性凋亡改善糖尿病肾病的管球损伤
Yan Liu,Chun Hu,Shilu Luo et al.
Yan Liu et al.
Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with limited therapeutic options. S14G-humanin (HNG), a potent analog of humanin, exerts protective effects in various diseases, but i...
Role of Genetic Polymorphisms on Opioid Safety and Efficacy in Cancer Pain: A Systematic Review and Meta-Analysis [0.03%]
阿片类药物治疗癌痛安全性和有效性的系统评价和meta分析：基因多态性的作用
Mikail Akan,Aleksandra Panina,Mikhail Khandokhin et al.
Mikail Akan et al.
Pain is one of the most prevalent and challenging symptoms in cancer, and opioids remain central to its management. Genetic factors are thought to underlie interindividual variability in opioid response, yet findings across pharmacogenomic ...
Vanillic acid protects vertebral endplate chondrocytes against oxidative stress and inflammation via Nrf-2/HO-1 pathway [0.03%]
中华草珊瑚茋通过Nrf-2/HO-1信号通路保护椎体终板软骨细胞抵抗氧化应激及炎症损伤
Yuandong Shao,Lili Dai,Xiujuan Cui et al.
Yuandong Shao et al.
Cartilage endplate (CEP) plays essential roles in the initiation and progression of intervertebral disc degeneration. Vanillic acid (VA) is widely used as a food additive and has been shown to exert cardioprotective, anti-inflammatory, and ...