EGCG-Biotin-Pal-GHK Composition Modulates TGF-β and BMP Pathways in Scalp Microenvironment for Treating Stress-Induced Alopecia [0.03%]
EGCG-生物素-棕榈酸GHK复合物通过调节头皮微环境中的TGF-β和BMP通路治疗压力引起的脱发
Xiaodan Zheng,Na Wang,Hewei Ma et al.
Xiaodan Zheng et al.
Chronic stress commonly precipitates telogen effluvium (TE), but sustained stress can further induce follicular miniaturization and fibrosis. Thus, stress-induced alopecia may be considered a pathological continuum that progresses from TE t...
Mechanism of Quercetin in the treatment of oral ulcer through network pharmacology and experimental validation [0.03%]
网络药理学和实验验证结合指导檞皮素治疗口腔溃疡的作用机制研究
Xiaomin Zeng,Yiling Li,Hairong Wang et al.
Xiaomin Zeng et al.
Oral ulcer is one of the most prevalent oral disorders, and is characterized by a high tendency to recur. Quercetin, a naturally occurring flavonoid, possesses antioxidant and anti-inflammatory properties. However, the mechanisms underlying...
Nobiletin restores colonic epithelial homeostasis in DSS-induced colitis with involvement of the aryl hydrocarbon receptor [0.03%]
楠皮素通过芳香烃受体调节结肠上皮细胞稳态改善葡聚糖硫酸钠诱导的鼠结肠炎
Xinru Li,Han Wu,Yong Yang et al.
Xinru Li et al.
Aryl hydrocarbon receptor (AhR) agonist facilitates the repair of damaged intestinal barriers in experimental colitis. Nobiletin, a distinct polymethoxyflavone present in citrus peel, has been reported to mitigate Dextran sulfate sodium (DS...
An excitatory projection from ventromedial hypothalamus to lateral hypothalamus mediates stress-induced reinstatement of alprazolam-conditioned place preference in male mice [0.03%]
雄性小鼠从腹内侧下丘脑到外侧下丘脑的兴奋性投射介导了压力诱导的地西泮条件位置偏好的再现
Zhipeng Song,Nianci Li,Rui Song et al.
Zhipeng Song et al.
Alprazolam (Alp) is a clinically common benzodiazepine (BZD) with a potential risk of abuse, yet the mechanisms underlying its reinstatement remain unclear. In this study, a conditioned place preference (CPP) paradigm combined with forced s...
Alloimperatorin enhances chemosensitivity by modulating the c-MYC/NBS1 axis to induce sustained DNA damage [0.03%]
alloimperatorin通过调节c-MYC/NBS1轴诱导持续性DNA损伤从而增强化学敏感性
Shuting Han,Jiaru Wang,Jiao Xue et al.
Shuting Han et al.
Chemoresistance is a significant factor in the failure of cancer treatment. Although some chemotherapeutic combination regimens are linked to DNA damage repair processes, the therapeutic potential of TCM-derived small molecules that target ...
Preclinical evaluation of itraconazole in docetaxel-resistant prostate cancer xenograft models [0.03%]
伊曲康唑对多西他赛耐药前列腺癌异种移植模型的药效学评估研究
Luciano O Souza,Annette Bartels,José M A Moreira
Luciano O Souza
Docetaxel (DTX) resistance remains a major barrier in metastatic prostate cancer, often driven by ABCB1 efflux and activation of survival pathways. We investigated the therapeutic impact of itraconazole (ITZ), a multifunctional antifungal a...
Effects of chronic treatment with acetylcholine receptor agonists on ethanol self-administration in male cynomolgus monkeys [0.03%]
乙酰胆碱受体激动剂慢性治疗对雄性食蟹猴酒精自助饮用的影响
Emily A Cronin,Lindsey K Galbo-Thomma,Phillip M Epperly et al.
Emily A Cronin et al.
Alcohol use disorder (AUD) affects 400 million individuals over age 15 worldwide but
4-Methylcatechol attenuates NLRP3 inflammasome activation to limit inflammation [0.03%]
对甲基儿茶酚通过抑制NLRP3炎性小体的激活而限制炎症反应
Danhui Qin,Yue Fu,Hongyi Kong et al.
Danhui Qin et al.
NACHT-, LRR- and pyrin domain-containing protein 3 (NLRP3) is an intracellular sensor that detects exogenous pathogenic invasions and endogenous cellular damage, leading to the NLRP3 inflammasome activation, which plays vital roles in host ...
Targeting the METTL14/Wnt9a/β-catenin pathway with pharmacological inhibitors enhances radiotherapy and immunotherapy efficacy in non-small cell lung cancer [0.03%]
靶向METTL14/Wnt9a/β-catenin通路的药理抑制剂可增强非小细胞肺癌放射治疗和免疫治疗的效果
Kaifeng Ji,Rong Yu,Wei Zhang et al.
Kaifeng Ji et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality, with its molecular heterogeneity posing a therapeutic challenge. This study investigates the pharmacologically targetable METTL14-mediated pathway in modulating...
Corrigendum to "Low-molecular-weight fucoidan inhibits HMGB1-induced thromboinflammation by modulating HMGB1-TLR4 axis" [Eur. J. Pharmacol. 1030 (2026) 179138 /1-13 pages] [0.03%]
关于“低分子量褐藻糖胶通过调节HMGB1-TLR4轴抑制HMGB1诱导的血栓炎症”的勘误说明(Corrigendum to "Low-molecular-weight fucoidan inhibits HMGB1-induced thromboinflammation by modulating HMGB1-TLR4 axis" [Eur. J. Pharmacol. 1030 (2026) 179138 /1-13 pages])
Muhammad Awais,Siwen Fang,Xue Chen et al.
Muhammad Awais et al.
Published Erratum
European journal of pharmacology. 2026 Aug 5:179184. DOI:10.1016/j.ejphar.2026.179184 2026