Evolocumab alleviates atherogenesis by inhibiting inflammation-mediated endothelial cell activation via the PI3K/AKT/NF-κB pathway [0.03%]
Chao Peng,Gui-Jing Liu,Jian Li et al.
Chao Peng et al.
Atherosclerosis, a chronic inflammatory disease, is the most relevant cause of ischaemic stroke or myocardial infarction. Vascular endothelial cells (ECs) play a significant role in the development of atherosclerosis. In this chronic inflam...
Repositioning of nonsedating antihistamine Ebastine for anti-lung adenocarcinoma based on EGFR/ERBB2 dual-targeting strategy [0.03%]
Yuehua Yu,Zixuan Li,Yuan He et al.
Yuehua Yu et al.
Lung adenocarcinoma is a highly fatal carcinoma worldwide with limited therapeutic options. We identified EGFR/ERBB2 as promising dual targets through integrative analysis of clinical data and TCGA database. Molecular docking and cytotoxici...
UC2288 decreases the viability and metastatic activity of human Uveal melanoma cells via activating the AMPK/eIF2/ATF4 ER stress axis [0.03%]
Janney Z Wang,Yihe Niu,Xue Zhu et al.
Janney Z Wang et al.
Uveal melanoma (UM) is the primary intraocular malignancy in adults and has an extremely poor prognosis due to a high rate of metastasis. Because current drug options are generally ineffective, there is an urgent need for new agents with an...
Mesenchymal stem cell exosomes and platelet-rich fibrin repair endometrial injury in rats: Insights into histological regeneration, inflammation modulation, and molecular signaling crosstalk [0.03%]
Mohamed S Kishta,Neveen A Salem,Rania Elgohary et al.
Mohamed S Kishta et al.
Introduction: Endometrial injury is a leading cause of impaired endometrial receptivity, fibrosis, and defective vascularization, resulting in implantation failure and infertility. Conventional treatments such as cell tra...
S-nitrosylation of AMP-activated protein kinase beta 1 drives atherosclerotic calcification in diabetes [0.03%]
Lin Chen,Sheng-Nan Zhou,Rui-Hang Tan et al.
Lin Chen et al.
Background: Diabetes constitutes a risk factor for atherosclerotic calcification, which is highly associated with phenotypic switching in vascular smooth muscle cells (VSMCs). Protein cysteine S-nitrosylation plays a cruc...
Decursin, a bioactive compound from Angelica gigas, suppresses mast cell activation by targeting Fyn kinase and attenuates IgE-mediated anaphylactic responses in mice [0.03%]
Ji-Young Yoon,Hyun-Woo Kim,Jin-Hyeon Hwang et al.
Ji-Young Yoon et al.
Allergy is a prevalent, chronic inflammatory condition in which otherwise innocuous antigens elicit maladaptive immune responses, causing significant morbidity and ongoing healthcare utilization worldwide. Despite advances in diagnosis and ...
Josh Hunt,Yogesh Rakholia,Tiba Alshammari et al.
Josh Hunt et al.
Introduction: Population-based studies show that chronic pain is associated with increased alcohol use and reduced pain, increasing the risk of hazardous drinking and developing alcohol use disorders (AUD). Preclinical mo...
Hao Duan,Yanqiu Wang,Qiao Wang et al.
Hao Duan et al.
Background: Emerging evidence highlights the pivotal role of ferroptosis in the pathophysiology of diabetic nephropathy (DN). This study aimed to identify potential ferroptosis-related genes (FRGs) in DN through bioinform...
6-Shogaol ameliorates experimental colitis and colitis-associated colorectal cancer in mice through the Nrf2-Keap1 signaling pathway [0.03%]
Na Li,Hehe Shi,Wei Du et al.
Na Li et al.
The progression from ulcerative colitis to colitis-associated colorectal cancer (CAC) represents a significant clinical challenge. 6-Shogaol, a bioactive phenolic compound of ginger, exhibits anti-inflammatory, antioxidant, and anti-tumor p...