Magnolol suppresses TKI-resistant EGFR-mutant lung cancer by inhibiting EGFR and AXL-cMyc [0.03%]
Magnolol通过抑制EGFR和AXL-cMyc抑制TKI耐药性EGFR突变型肺癌
Chin-Chuan Chen,Tong-Hong Wang,Yann-Lii Leu et al.
Chin-Chuan Chen et al.
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), particularly osimertinib, remains a major therapeutic challenge in EGFR-mutant lung cancer. In this study, we evaluated the pharmacological acti...
Paeoniflorin alleviates urushiol-induced pruritus in mice by inhibiting Erk/CCL2 pathway [0.03%]
白头翁素通过抑制Erk/CCL2信号通路缓解漆酚诱导的小鼠瘙痒症
Huan You,Lu Tai,Yulu Li et al.
Huan You et al.
Paeoniflorin (PAE), a bioactive monoterpene glycoside derived from the roots of Paeonia lactiflora (P. lactiflora), has been traditionally used in East Asian medicine for its anti-inflammatory and immunomodulatory properties. However, its p...
14,15-EET mitigates sepsis-induced cardiomyopathy by inhibiting cardiomyocyte ferroptosis via PPARα activation [0.03%]
14,15-环氧二十碳三烯酸通过激活PPARα抑制心肌细胞铁死亡从而缓解脓毒症诱导的心肌病
Wenbin Nan,Xiaoqing Jiang,Xu Cai et al.
Wenbin Nan et al.
Background: Ferroptosis has emerged as a central driver of sepsis-induced cardiomyopathy. Epoxyeicosatrienoic acids (EETs) possess cardioprotective properties, but whether 14,15-EET confers protection in septic cardiomyop...
Therapeutic effects of methotrexate encapsulated in hyaluronic acid-coated exosomes derived from Wharton's jelly mesenchymal stem cells in a rat model of rheumatoid arthritis [0.03%]
透明质酸修饰细胞外囊泡递送甲氨蝶呤治疗类风湿关节炎研究
Zahra Akbari Jonoush,Mahmoud Gharbavi,Mehri Ghafourian et al.
Zahra Akbari Jonoush et al.
Background: Methotrexate (MTX) is widely used for treating rheumatoid arthritis (RA); however, its clinical application is limited because of its nonspecific distribution and significant long-term adverse effects. We deve...
Corrigendum to "Sodium channel Nav1.6 involved in modulating isoflurane-induced perioperative cognitive disorder of mice" [Eur. J. Pharmacol. 1015 (2026) 10-10/ 178545] [0.03%]
“钠通道Nav1.6参与异氟醚诱导的小鼠围术期认知障碍的调控」一文的勘误( Eur. J. Pharmacol. 1015 (2026) 10-10/ 178545 )
Min Xia,Bin Wang,Jincheng Lu et al.
Min Xia et al.
Published Erratum
European journal of pharmacology. 2026 Jan 26:178583. DOI:10.1016/j.ejphar.2026.178583 2026
TGR5 rescues renal ischemia-reperfusion injury by suppressing ferroptosis and cAMP/PKA/Nrf2 axis [0.03%]
TGR5通过抑制铁死亡和cAMP/PKA/Nrf2轴拯救肾缺血再灌注损伤
Suhan Zhou,Honghong Wang,Huanhuan Zhu et al.
Suhan Zhou et al.
Background: Emerging evidence highlights the critical role of ferroptosis in the pathophysiology of both acute kidney injury (AKI) and chronic kidney disease (CKD). Nuclear factor erythroid 2-related factor 2 (Nrf2), whic...
Metabolomic Profiling of Cocaine Plus Ethanol Poly-consumption in Young Adult Rats: Insights into the Incubation of Drug Seeking [0.03%]
年轻大鼠反复摄入可卡因和酒精的代谢组学分析：药物寻求增强的代谢机制研究
Lucía Garrido-Matilla,Alberto Marcos,Carlos León et al.
Lucía Garrido-Matilla et al.
The combined use of cocaine and alcohol is highly prevalent and produces more severe effects than either drug alone. This study investigates this polysubstance abuse pattern by modelling the incubation of cocaine craving, both alone and in ...
Yuqing Li,Haoqi Li,Zijie Cheng et al.
Yuqing Li et al.
Cardiovascular disease (CVD) is a major public health issue causing high mortality rates worldwide. Its pathogenesis is complex and diverse, its treatment costs are high, and it represents a serious threat to human health. In recent years, ...
Remodeling of androgen metabolism network mediated by UGT2B: a new perspective on treatment resistance in prostate cancer [0.03%]
UGT2B介导的雄激素代谢网络重塑：前列腺癌治疗耐药的新视角
YuanYuan Wang,Chenxi Tu,Hao Qin et al.
YuanYuan Wang et al.
Prostate cancer (PCa) is the most common and aggressive malignancy in males worldwide, with its progression influenced by multiple factors. Androgens, the primary regulators of prostate cell growth and physiology, play a pivotal role in PCa...
Glycyrrhetinic acid ameliorates cholestatic liver injury by inhibiting acHMGB1/TLR2-mediated crosstalk between hepatocytes and macrophages [0.03%]
甘草酸通过抑制acHMGB1 / TLR2介导的肝细胞和巨噬细胞之间的串话来改善胆汁淤积性肝损伤
Fengyi Weng,Bin Zou,Jing Zhao et al.
Fengyi Weng et al.
The crosstalk between hepatocytes and macrophages is a key mechanism driving the pathogenesis of cholestatic liver injury (CLI). Glycyrrhetinic acid (GA), a bioactive compound derived from licorice, offers protection against CLI, but its ef...