Targeting TRPA1 antagonists for nociplastic pain: systematic review and meta-analysis of preclinical evidence [0.03%]
靶向TRPA1拮抗剂治疗假性疼痛：系统回顾和荟萃分析的证据研究
Caren Antoniazzi,Helen Alves Brito,Patrícia Rodrigues et al.
Caren Antoniazzi et al.
Nociplastic pain results from altered nociceptive processing without apparent tissue damage. Effective treatment remains challenging due to limited biomarker availability and poor response to conventional analgesics. Transient receptor pote...
Poly(I:C) and QS-21 combination suppresses breast tumor growth and metastasis by repolarizing tumor associated macrophages to anti-tumor macrophages [0.03%]
聚肌胞和QS-21通过将肿瘤相关巨噬细胞重编程为抗肿瘤表型来抑制乳腺癌生长及转移
Haoxin Zheng,Yanyan Jin,Zixuan Wang et al.
Haoxin Zheng et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer defined by a paucity of targeted therapies, high metastatic propensity, and an immunosuppressive tumor microenvironment rich in tumor-associated macrophages (TAM...
The role of ginsenosides in obesity-associated sarcopenia: Focus on E3 ubiquitin ligase-mediated regulation of protein homeostasis [0.03%]
人参皂苷在肥胖相关性肌少症中的作用：重点关注E3泛素连接酶介导的蛋白质稳态调节
Wei Zhou,Pei-Tong Li,Hong-Yuan Li et al.
Wei Zhou et al.
Obesity-associated sarcopenia (OAS) is a complex metabolic disorder characterized by excessive adiposity accompanied by progressive skeletal muscle loss, largely driven by impaired protein homeostasis. The ubiquitin-proteasome system (UPS) ...
Epigenetic Regulation in Liver Fibrosis: Focus on the Chromatin Accessibility Landscape [0.03%]
肝纤维化中的表观遗传调控：着重于染色质可及性图谱
Xue Dong,Ming-Hui Li,Zheng-Lin Qiao et al.
Xue Dong et al.
Liver fibrosis is a key pathological process in the progression of chronic liver disease to cirrhosis and hepatocellular carcinoma, with core features including hepatic stellate cells (HSCs) activation and extracellular matrix (ECM) deposit...
CTSB-Associated Inflammation and Macrophage Interaction in Heart Failure Following Myocardial Infarction and Potential Therapeutic Implications of Quercetin [0.03%]
心肌梗死后心脏衰弱相关的CTSB炎症及巨噬细胞相互作用及檞皮素的潜在治疗作用
Ling Tan,Ran Ding,Guiyu Li et al.
Ling Tan et al.
Post-myocardial infarction inflammation and maladaptive remodeling are major drivers of heart failure, but the role of cathepsin B (CTSB) in quercetin-associated cardioprotection remains unclear. In this study, public bulk transcriptomic an...
Nitrendipine synergizes with multiple antibiotics against methicillin-resistant Staphylococcus aureus by disrupting membrane homeostasis [0.03%]
尼尔地平通过干扰膜稳态增强多种抗生素对耐甲氧西林金黄色葡萄球菌的抗菌活性
Xiaomin Ren,Huiqiang Zhang,Yuxi Liu et al.
Xiaomin Ren et al.
The emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of innovative therapeutic strategies, including the repurposing of non-antibiotic drugs as antibiotic adj...
Captopril alleviates vascular endothelial dysfunction by regulating TRPV1 and activating the eNOS pathway [0.03%]
卡托普利通过调节TRPV1和激活eNOS通路缓解血管内皮功能障碍
Jing Lu,Qiuyue Wang,Wei Zheng et al.
Jing Lu et al.
Background: Vascular endothelial dysfunction (VED) underlies the pathogenesis of diabetic cardiovascular complications. Captopril (CAP), an angiotensin-converting enzyme inhibitor widely used in clinical practice, remains...
Probenecid enhances relaxation induced by cyclic adenosine monophosphate- and cyclic guanosine monophosphate-augmenting substances in rat prostate, bladder, and corpus cavernosum: a potential repurposing strategy [0.03%]
丙磺舒增强环鸟苷酸和环腺苷酸增效物质引起的雄鼠前列腺、膀胱及阴茎海绵体松弛：一种再定位策略
Guilherme Ruiz Leonardi,Mariana Burille Moretti,João Correa et al.
Guilherme Ruiz Leonardi et al.
Prostate, bladder, and corpus cavernosum share common pathophysiological mechanisms involving smooth muscle tone regulation through cyclic nucleotide signaling, particularly cAMP and cGMP pathways. Probenecid, a classical uricosuric agent, ...
Kaempferol alleviates myocardial ischemia-reperfusion injury by activating the Nrf2/GPX4 signaling pathway to inhibit ferroptosis [0.03%]
山柰酚通过激活Nrf2/GPX4信号通路抑制铁死亡从而缓解心肌缺血再灌注损伤
Xuan Tang,Weiguang Zou,Tao Peng et al.
Xuan Tang et al.
Myocardial ischemia-reperfusion injury (MIRI) remains a major cause of myocardial dysfunction after reperfusion therapy, and effective pharmacological interventions are still limited. Ferroptosis plays a pivotal role in MIRI pathogenesis. T...
Pharmacological targeting of the extracellular cGAMP-ENPP1 axis in cancer immunotherapy: mechanisms, biomarkers, and translational strategies [0.03%]
癌症免疫治疗中针对细胞外cGAMP-ENPP1轴的药理学靶向：机制、生物标志物和转化策略
Kai-Lang Mu,Rui-Qi Liao,Jun-Li Xie et al.
Kai-Lang Mu et al.
The extracellular cyclic GMP-AMP (cGAMP)-ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) axis is an emerging pharmacological target that links tumor-intrinsic DNA stress to antitumor immunity. Tumor cells can generate cGAMP in re...