Inhibition of the Serotonin Transporter and Risk of Heart Valve Disease: A Systematic Review and Meta-Analysis [0.03%]
Anthony Campbell,Arianna Adamo,Emre Bektik et al.
Anthony Campbell et al.
Background: The serotonin transporter (SERT) plays an essential role in regulating a wide range of physiological and psychological processes, including neurotransmitter homeostasis, circadian rhythm, sleep regulation, pla...
SAHA induces immunogenic cell death in triple negative breast cancer cells and its efficacy is enhanced by SOCS3 functional replacement [0.03%]
Giuliano Castellano,Candida Bucciero,Alessia Cugudda et al.
Giuliano Castellano et al.
Triple negative breast cancer (TNBC) is an aggressive subtype associated with poor prognosis and limited therapeutic options. Epigenetic changes contribute to TNBC tumorigenesis, and histone deacetylase inhibitors (HDACi) have emerged as pr...
Heart-brain axis dysregulation in PTSD mice: Vagal-mediated insular cortex hyperactivity and its reversal by propranolol [0.03%]
Jingwen Niu,Wei Xia,Haipeng Li et al.
Jingwen Niu et al.
Background: While abnormal brain connectivity is central to PTSD, sympathetically-driven cardiac dysfunction also occurs. Given the established role of cardiac modulation of brain function and its implication in psychiatr...
Jing Feng,Tong Zhao,Lina Yao et al.
Jing Feng et al.
A cold environment is a significant risk factor for cardiovascular diseases (CVDs), and its pathophysiological mechanisms involve complex interactions across multiple organ systems. However, the role of the liver as a central organ for meta...
DL-norvaline attenuated HFD-induced metabolic inflammation and dysfunction with integrated pharmacokinetic, biodistribution, and safety evaluation [0.03%]
Xin Li,Xin Wang,Xin Lü
Xin Li
Metabolic inflammation is a major contributor to obesity-related metabolic disturbances, yet safe and bioavailable dietary candidates with multi-organ activity remain limited. DL-norvaline, a nonproteinogenic amino acid, was examined for it...
Muhammad Adnan Bashir,Ihsan Ullah,Gulshan Aara et al.
Muhammad Adnan Bashir et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive neuronal loss, cognitive impairment, oxidative stress, neuroinflammation, and aggregation of abnormal proteins, including amyloid precursor...
Glycin-proline-hydroxyproline Modified N-terminal 20 Peptide from CEMP1 Blocks Calcium Ion Influx to Alleviate Inflammatory Response in Gingival Fibroblasts [0.03%]
Yuxiang Sun,Yanqian Zhao,Li Xu et al.
Yuxiang Sun et al.
Gingival fibroblasts play a pivotal role in the progression of periodontitis, and targeted inhibition of calcium ion influx in gingival fibroblasts represents a potential therapeutic strategy for ameliorating periodontal inflammation. The N...
Brimonidine attenuates choroidal thinning and hypoperfusion in guinea pigs with form-deprivation myopia: Involvement of NOS and TGF-β1 [0.03%]
Fang Zeng,Hong He,Yanting Luo et al.
Fang Zeng et al.
Myopia is a major public health concern that poses a serious threat to vision. The combination of precise monitoring of changes in the choroidal structure and blood flow, along with early prevention and control through pharmacological inter...
Multifaceted mechanisms of 4-hydroxybenzaldehyde in reducing hemorrhagic transformation in ischemic stroke ameliorating based on transcriptomics and metabolomics [0.03%]
Ming Chen,Xiaoyu Tan,Dongxiong Hu et al.
Ming Chen et al.
Aim of the study: The PI3K-AKT signaling pathway has emerged as a central modulator in the pathophysiology of hemorrhagic transformation (HT). Gastrodia elata Blume, a classic neuroprotective herb used in Traditional Chin...
N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide ameliorates lipopolysaccharide-induced depression-like behavior in mice targeting inflammatory, apoptotic, and oxidative pathways [0.03%]
Camila Simões Pires,Marcia Juciele da Rocha,Narryman Pinto Zuge et al.
Camila Simões Pires et al.
The organoselenium compound CF3SePB has previously shown promise as an antidepressant due to its modulation of the serotonergic system. This study aimed to investigate the potential of CF3SePB to ameliorate depressive-like behaviors induced...