Gallic acid, renal redox balance and NRF2-Related transcript-level modulation in a rat model of contrast-associated acute kidney injury [0.03%]
没食子酸对对比剂致急性肾损伤的肾脏氧化还原平衡及NRF2相关转录调控影响研究
Nurhan Akyürek Bayhan,Demet Gündüz,Nasıf Fatih Karakuyu et al.
Nurhan Akyürek Bayhan et al.
Introduction: Contrast-associated acute kidney injury (CA-AKI) is a clinically relevant complication of iodinated contrast exposure. This study investigated whether gallic acid (GA) attenuates diatrizoate (Urografin 76%; ...
GLUT1/SGLT1 balance associates with high-glucose buffering of metformin-induced lysosomal deacidification and mTORC1 inhibition in colorectal cancer [0.03%]
GLUT1/SGLT1平衡与高血糖缓冲二甲双胍诱导的结直肠癌溶酶体脱酸和mTORC1抑制有关
Badr-Eddine Allal,Susana Mendonça,Abdelkader Bounaama et al.
Badr-Eddine Allal et al.
Metformin has anticancer potential, but benefit in colorectal cancer (CRC) is heterogeneous and determinants of tumor cell response remain unclear. We tested whether extracellular glucose and the relative expression of glucose transporter 1...
10-Hydroxy-2-decenoic acid, a bioactive component of royal jelly, induces p53-Mediated apoptosis in cholangiocarcinoma in vitro and in vivo [0.03%]
10-羟基-2-癸烯酸通过介导p53依赖性凋亡作用体外和体内抑制胆管癌细胞增殖
Guohong Yan,Jiakao Zhang,Ziyan Lu et al.
Guohong Yan et al.
The poor prognosis and limited treatment options for cholangiocarcinoma (CCA) continue to drive the search for novel therapeutics with clear mechanisms of action. 10-hydroxy-2-decenoic acid (10-HDA) is a unique bioactive fatty acid isolated...
Finerenone ameliorated ventricular remodeling post myocardial infarction in rats by reducing NF-KB pathway-mediated pyroptosis [0.03%]
芬戈利蒙特通过减少NF-κB介导的细胞焦亡减轻大鼠心肌梗死后的心室重构
Xue Sun,Linlin Song,Qipei Liu et al.
Xue Sun et al.
Myocardial infarction (MI) remains a leading cardiovascular cause of mortality in patients, primarily driven by adverse post-MI ventricular remodeling tightly linked to inflammation. Finerenone, the first non-steroidal mineralocorticoid rec...
Differential modulation of central sensitization pathways by common antipsychotics in a paclitaxel-induced neuropathic pain model [0.03%]
常见抗精神病药物通过分化调节紫杉醇诱导的神经病理性疼痛模型中的中枢敏化通路发挥作用
Ayşenur Budak Savaş,Fatma Yeşilyurt,Cemil Bayram et al.
Ayşenur Budak Savaş et al.
Neuropathic pain is a chronic condition characterized by central sensitization (CS) and inadequacy of current treatments. Although antipsychotics are considered potential adjuvant treatments, they are generally treated as a homogeneous clas...
Carabrone alleviates neuroinflammation by covalently targeting ubiquitin conjugating enzyme UBE2D3 in experimental autoimmune encephalomyelitis [0.03%]
卡布拉酮通过共价靶向UBE2D3减轻自身免疫性脑脊髓炎中的神经炎症
Huaiping Tang,Liang Sun,Bin Jia et al.
Huaiping Tang et al.
Multiple sclerosis (MS) is an incurable and progressive inflammatory disease of the central nervous system (CNS) characterized by inflammatory demyelination, chronic axonal damage, and neurodegeneration. Carabrone (CA), a sesquiterpene lact...
The natural coumarin 7-methoxy-8-isopentenyloxycoumarin alleviates LPS-induced inflammation by suppressing NF-κB and the MAPK/AP-1 pathways and accelerating COX-2 proteasomal degradation [0.03%]
一种天然香豆素7-甲氧基-8-异戊烯氧基香豆素通过抑制NF-κB和MAPK/AP-1途径并加快COX-2蛋白酶体降解来缓解LPS诱导的炎症反应
Shiu-Wen Huang,Hsiu-Chen Chen,Antonio Lupia et al.
Shiu-Wen Huang et al.
Inflammatory diseases impose a significant global healthcare burden, necessitating the development of effective anti-inflammatory agents. Many clinically used drugs are isolated from plants or derived from natural products via semi-syntheti...
Preclinical characterization of the efficacy and safety of histamine H3 receptor antagonist, LINS01022, as a novel analgesic for chronic neuropathic pain treatment [0.03%]
组胺H3受体拮抗剂LINS01022用于治疗慢性神经病理性疼痛的镇痛药效及安全性评价的药物前临床研究
Magdalena Maciuszek,Magdalena Białoń,Mateusz Królewski et al.
Magdalena Maciuszek et al.
Neuropathic pain is a disorder that represents a significant clinical challenge, while is refractory to therapeutic interventions. Given that the histamine H3 receptor (H3R) is a promising target for new analgesics, we aimed to determine th...
Developmental exposure to resveratrol induces context-dependent vascular effects in adult offspring: protection in SHR and adverse remodeling in normotensive rats [0.03%]
发育期接触白藜芦醇诱导的子代成人血管的上下文相关效应：对SHR具有保护作用，但会增加正常血压大鼠的心脏重塑风险
Marcela M Blascke de Mello,Ruan Rodrigues de Oliveira,Beatriz Quaresemin Gomes et al.
Marcela M Blascke de Mello et al.
Resveratrol reduces oxidative stress and improves nitric oxide (NO) bioavailability in the aorta of adult offspring from spontaneously hypertensive rats (SHR) when administered during pregnancy. In this study, we investigated whether parent...
The role and mechanism of rosiglitazone in endothelial-to-mesenchymal transition in pulmonary hypertension [0.03%]
罗格列酮在肺动脉高压内皮细胞转分化为间充质细胞中的作用和机制研究
Aoxue Yuan,Yaqian Bai,Yuanhang Jiang et al.
Aoxue Yuan et al.
Objective: Pulmonary hypertension (PH) involves endothelial-to-mesenchymal transition (EndMT) in vascular remodeling. Rosiglitazone (RSG), a peroxisome proliferator-activated receptor gamma agonist, alleviates PH, but its...