The precision revolution: Machine learning and the future of personalized therapy in hematologic malignancies [0.03%]
精准医疗革命：机器学习在血液系统恶性肿瘤个性化治疗中的应用与展望
Ling Xu,Yangqiu Li,Michał Marczyk et al.
Ling Xu et al.
Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model [0.03%]
Glycyl-L-(histidyl-L-赖氨酸-Cu2+(GHK-Cu)减轻斑马鱼幼虫模型中CuSO4或LPS诱导的炎症作用
Jing Hu,Chao Zhang,Feifei Wang
Jing Hu
Inflammation serves as a basic defense mechanism against both internal and external threats, while the unresolved or excessive inflammation can lead to irreversible tissue damage. Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu), a bioactive tripep...
Friedelin and 6-methoxyflavone from Imperata cylindrica ameliorate APAP-induced liver injury by activating AKT1 to suppress Caspase-3/GSDME-mediated pyroptosis [0.03%]
日本血grass中的friedelin和6-甲氧基黄酮通过激活AKT1来抑制Caspase-3/GSDME介导的焦亡从而改善APAP诱导肝损伤
Pingting Wu,Weilai Chen,Jie Li et al.
Pingting Wu et al.
Acetaminophen (APAP) overdose causes acute liver injury (ALI) by triggering regulated hepatocyte death. While Imperata cylindrica (Imperatae Rhizoma) (IR) is used in traditional medicine for its hepatoprotective effects, its active compound...
From mechanisms to therapeutics: The expanding role of cell-based strategies in Alzheimer's disease [0.03%]
从机制到治疗：细胞疗法在阿尔茨海默病中角色的扩大
Xuan Sun,Wenwen Deng,Jiangnan Yu et al.
Xuan Sun et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. Its core pathologies include the deposition of amyloid-β plaques, the formation of neurofibrillary tangles composed of hyperphosphoryl...
Acute hyperglycemia induces NETosis and futile recanalization after ischemic stroke via RAGE/DIAPH1 pathway [0.03%]
急性高血糖通过RAGE/DIAPH1途径在缺血性脑卒中后诱导NETosis和无效再通
Qinhong Li,Bo Wu,Zirui Chen et al.
Qinhong Li et al.
Acute hyperglycemia significantly exacerbates cerebral ischemia‒reperfusion injury and worsens clinical outcomes. Notably, insulin-based hypoglycemic therapy during the perioperative period of recanalization does not have a clear protectiv...
IGF-1 attenuates high fat diet-elicited cardiomyopathy via arachidylcarnitine-dependent suppression of ferroptosis and mitochondrial dysfunction [0.03%]
胰岛素样生长因子通过花生四烯基 carnitine 依赖性抑制铁死亡和线粒体功能障碍来缓解高脂饮食诱发的心肌病
Lin Wang,Mingzhi Shen,Miyesaier Abudureyimu et al.
Lin Wang et al.
Obesity is associated with low circulating IGF-1 levels, mitochondrial injury, and myocardial anomalies, however, the precise interplay between IGF-1 and obesity cardiomyopathy remains unclear. Our work evaluated the impact of IGF-1 on high...
Inhibition of PKM2 lactylation by geniposide ameliorates synovial hyperplasia in experimental arthritis [0.03%]
Gardenioside通过抑制PKM2乳酸化改善实验性关节炎滑膜增生
Bing Li,Pei-Rong Gan,Jing Pang et al.
Bing Li et al.
Glycolytic reprogramming-driven aberrant proliferation of FLSs is a major cause of synovial hyperplasia in rheumatoid arthritis (RA). Geniposide (GE), an iridoid glycoside extracted from the plant Gardenia jasminoides J. Ellis, has been con...
Time-dependent neuroprotective effects of YL-IPA08 in repetitive mild traumatic brain injury associated with changes in Caprin1/SHH signaling [0.03%]
YL-IPA08在反复轻度创伤性脑损伤的时间依赖性神经保护作用及其对Caprin1/SHH信号通路的影响
Cedi Yu,Qingxin Ye,Zengfei Song et al.
Cedi Yu et al.
Repetitive mild traumatic brain injury (rmTBI) triggers chronic neuroinflammation, oxidative stress, and synaptic dysfunction, resulting in long-term cognitive and emotional impairments. Effective pharmacological interventions remain scarce...
Trace amine associated receptors in neuronal circuits: Mechanistic insights for therapeutic interventions [0.03%]
神经元回路中的追踪胺相关受体：治疗干预的机制见解
Mariya Jahangir,Lakshminarayanan Gowtham,Madhu Nath et al.
Mariya Jahangir et al.
Trace amines (TAs) are typical biogenic amines which are found in the human body in pico-to-femto grams in the body fluids and tissues. TAs play crucial role in various physiological processes. Initially TAs were not considered significant ...
Proanthocyanidins alleviate ovarian ischemia reperfusion injury by inhibiting ferroptosis through the SIRT1/Nrf2/GPX4 pathway [0.03%]
白藜芦醇通过SIRT1/Nrf2/GPX4信号通路抑制铁死亡从而缓解卵巢缺血再灌注损伤
Xin Liu,Min Hou,Xingjiao Lv et al.
Xin Liu et al.
Ovarian ischemia reperfusion injury (IRI) is a dangerous gynecological disorder caused by ovarian torsion from the ovarian mass and surgical manipulation. To improve patient outcomes, it is necessary to explore more effective therapeutic ap...