Nintedanib is a potent FLT3 inhibitor with activity against FLT3-ITD and overcomes the gatekeeper F691L resistance mutation in acute myeloid leukemia [0.03%]
尼替尼达滨是一种高效的FLT3抑制剂，对FLT3-ITD有活性，并能克服急性髓系白血病中的门keeper F691L耐药性突变
Cuiying Gu,Jiajun He,Jiaqi Fan et al.
Cuiying Gu et al.
Acute myeloid leukemia (AML) is a molecularly heterogeneous malignancy in which FMS-like tyrosine kinase 3 (FLT3) mutations, particularly internal tandem duplications (FLT3-ITD), occur in approximately 30% of cases and are associated with p...
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway [0.03%]
缓激肽通过依赖一氧化氮的途径调节内皮素-1增强和羊角拗素诱导的兔肺动脉高压相关心律失常
Yen-Yu Lu,Fong-Jhih Lin,Yao-Chang Chen et al.
Yen-Yu Lu et al.
Bradykinin, a vasoactive substance, lowers ventricular tachycardia inducibility in ischemic animal models. The right ventricular outflow tract (RVOT) has distinctive electrophysiological characteristics and calcium homeostasis, leading to i...
Mitochondrial dysfunction and senescence accompany glioblastoma cell death triggered by a putative metabolic inhibitor [0.03%]
线粒体功能障碍和衰老伴随假定的代谢抑制剂触发的胶质母细胞瘤细胞死亡而出现
Anjali Yadav,Shraddha Bhutkar,Shrikant Barot et al.
Anjali Yadav et al.
Glioblastoma (GBM) is a fatal cancer with a dismal prognosis and a dire need for novel chemotherapeutics. Metabolic reprogramming is an established hallmark of cancer. In our previous study on GBM, we aimed at targeting the metabolic reprog...
Safety and efficacy of remimazolam sedation for ICU patients on invasive mechanical ventilation: A meta-analysis of randomized controlled trials [0.03%]
瑞马唑仑用于机械通气重症患者镇静的有效性和安全性：随机对照试验的meta分析研究
Ze Xu,Jiacheng Lu,Saboor Saeed et al.
Ze Xu et al.
Background and aim: The management of sedation in mechanically ventilated intensive care unit (ICU) patients is very challenging in critical care medicine. Remimazolam and propofol are used as sedative agents for ICU pati...
The silymarin and quercetin-loaded pH-sensitive chitosan-tripolyphosphate/Eudragit® S100 nanoparticles improve acetic acid-induced colonic inflammation in rats by modulating Th1 cells, inflammatory cytokines, and oxidative stress [0.03%]
载有丝氨茋和芦丁的pH敏感性壳聚糖-三磷酸/ Eudragit® S100纳米颗粒通过调节Th1细胞，炎症细胞因子和氧化应激改善大鼠乙酸诱导的结肠炎
Nader Bagheri,Mehdi Badihi,Yousef Mirzaei et al.
Nader Bagheri et al.
Silymarin (SM) and quercetin (Que) are flavonoids with antioxidant and anti-inflammatory effects. Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation. This study aimed to develop pH-sensitiv...
Corrigendum to "Cinnamaldehyde ameliorates diabetic kidney disease via anti-inflammatory effects: Bridging traditional use and molecular mechanisms" [Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783] [0.03%]
关于“肉桂醛通过抗炎作用改善糖尿病肾病：传统用途与分子机制之间的桥梁”[Eur. J. Pharmacol. (2026) doi: 10.1016/j.ejphar.2026.178783] 的勘误表
Dan Yang
Dan Yang
Published Erratum
European journal of pharmacology. 2026 May 10:1023:178883. DOI:10.1016/j.ejphar.2026.178883 2026
Amygdalin attenuates post-ischemic neuroinflammation by targeting TLR4/NF-κB signaling and NLRP3 inflammasome in cerebral ischemia-reperfusion injury [0.03%]
杏仁素通过靶向TLR4/NF-κB信号和NLRP3炎性小体缓解脑缺血再灌注损伤后的神经炎症反应
Yan-Chen Wang,Hong-Yan Wang,Yi-Fan Yuan et al.
Yan-Chen Wang et al.
Cerebral ischemia-reperfusion injury (CIRI) is a major contributor to neuronal damage after ischemic stroke, and current therapies remain limited by a narrow therapeutic window and reperfusion-associated injury. Amygdalin (Amg) has anti-inf...
Lysosomal accumulation of masitinib alters autophagy via pH-dependent trapping [0.03%]
自噬通过pH依赖性捕获机制调节马替辛积聚在溶酶体内的过程
Abdulrahman El Sayed,Monika Kluzek,Remigiusz Serwa et al.
Abdulrahman El Sayed et al.
Small-molecule kinase inhibitors often exhibit complex cellular behaviors that cannot be explained solely by target inhibition. Masitinib is a clinically investigated tyrosine kinase inhibitor with reported anti-inflammatory and neuroprotec...
Functional β1-selectivity of novel pyrazoloquinolinones at GABAA receptors revealed by electrophysiology, mutagenesis and docking [0.03%]
新型吡唑喹啉酮化合物在GABAA受体上的功能β1选择性及其电生理学、突变分析和分子对接研究
Dominik Schnalzer,Celina Haller,Angelika M Doppler et al.
Dominik Schnalzer et al.
Gamma-aminobutyric acid type A (GABAA) receptors are ligand-gated anion channels, encoded by nineteen subunit genes in mammals. Recent cryo-electron microscopy studies of native human receptors from brain cortex revealed that β1 subunits c...
Pleiotropic mechanisms and translational trajectory of SGLT2 inhibitors in sepsis-induced cardiomyopathy: Navigating the evidence hierarchy [0.03%]
SGLT2抑制剂在脓毒症心肌病中的多效机制和转化轨迹：循证体系的构建与展望
Xinge Zhang,Liuyi Ren,Min Li et al.
Xinge Zhang et al.
Sepsis-induced cardiomyopathy (SICM) is a common but heterogeneous syndrome of acute myocardial dysfunction characterized by inflammatory dysregulation, endothelial and microcirculatory injury, mitochondrial bioenergetic failure, ionic inst...