Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance [0.03%]
核转录XIAP过表达的转录组变化揭示了IGFBP6/Wnt在乳腺癌细胞存活和化学抗性中的调节轴心
Bruna Dos Santos Mendonça,Renata Binato,Eliana Abdelhay et al.
Bruna Dos Santos Mendonça et al.
X-linked inhibitor of apoptosis protein (XIAP) is an antiapoptotic protein which plays canonical functions in the cytoplasm. However, we have previously demonstrated that nuclear XIAP is associated with increased cell growth and drug resist...
Ginsenoside Rb1 alleviates cerebral ischemia/reperfusion injury by suppressing oxidative stress and excessive autophagy via ATM-CHK2-Beclin 1 pathway [0.03%]
人参皂苷Rb1通过ATM-CHK2-Beclin 1途径抑制氧化应激和过度自噬来缓解脑缺血再灌注损伤
Yuqi Yuan,Xiaoying Shan,Yuqing Li et al.
Yuqi Yuan et al.
Recent studies have demonstrated that ginsenoside Rb1 (GRb1) exhibits neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury. However, whether GRb1 modulates autophagy and oxidative stress induced by cerebral I/R remains...
From pathology to precision therapy: Contemporary and emerging strategies in Alzheimer's disease treatment [0.03%]
从病理到精准治疗：阿尔茨海默病治疗的现况与前景策略
Swetha Belavadi,Sunil Kumar Kadiri
Swetha Belavadi
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by dementia, confusion, irritability, a lack of cognition, and mood swings. Since its discovery in 1906, many small molecules have been designed to block dise...
Apilimod in oncology: From non-malignant origins to emerging anti-cancer potential [0.03%]
Apilimod在肿瘤学中的应用：从非恶性起源到潜在的抗肿瘤作用
C Evrard,B Gündel,M Löhr et al.
C Evrard et al.
Apilimod is an emerging therapeutic compound whose clinical potential has renewed interest in the PIKfyve signaling pathway, a central regulator of endolysosomal trafficking and cellular homeostasis. This review provides a critical overview...
Piperlonguminine attenuates atherosclerosis in mice via phenotype switching inhibition of vascular smooth muscle cells [0.03%]
派伯隆古明因通过抑制血管平滑肌细胞表型转换改善小鼠动脉粥样硬化病情
Yun Sun,Defen Zhu,Xumei Luo et al.
Yun Sun et al.
Phenotypic switching of vascular smooth muscle cells (VSMCs) plays diverse roles in the development of atherosclerosis. These cells are a primary contributor to plaque formation and can transition between contractile and synthetic states in...
Intestinal-restricted Farnesoid X receptor agonist Fex3 alleviates cholestatic liver injury via FGF15-CYP7A1 axis [0.03%]
肠限制型法尼醇X受体激动剂Fex3通过FGF15-CYP7A1轴缓解胆汁淤积性肝损伤
Jiangzhou Song,Yi Wang,Rongrong Guo et al.
Jiangzhou Song et al.
Maintaining bile acids (BAs) homeostasis is a recognized key strategy for treating primary biliary cholangitis (PBC), with the farnesoid X receptor (FXR) playing a significant regulatory role in this process. Compared to systemic FXR agonis...
Glucose transporter 9 inhibition as a potential novel approach for lowering uric acid [0.03%]
葡萄糖转运蛋白9抑制有望成为降低血尿酸的新方法
Katsuya Deai,Kenji Fukui,Shiori Naruoka et al.
Katsuya Deai et al.
Glucose transporter 9 (GLUT9) is a uric acid transporter that plays a key role in maintaining uric acid homeostasis. JTT-763 is a novel GLUT9 inhibitor identified based on its uric acid transport inhibitory activity against human GLUT9 (hGL...
LS21013A-06, a PDE4 inhibitor, preserves blood-brain barrier integrity in experimental ischemic stroke models through PKA-dependent modulation of LECT2 [0.03%]
LS21013A-06通过PKA依赖性调节LECT2在实验性缺血性卒中模型中保护血脑屏障完整性（一种PDE4抑制剂）
Jiakang Wang,Chunyuan Zeng,Fei Ye et al.
Jiakang Wang et al.
Ischemic stroke (IS) disrupts the blood-brain barrier (BBB), thereby aggravating neurological deterioration. Loss of tight junction (TJ) and adherens junction (AJ) proteins is a key event in BBB breakdown, but the upstream mechanisms remain...
Inhibition of ferroptosis exerts renal protective effects in membranous nephropathy rats via the Nrf2/HO-1 pathway [0.03%]
铁死亡抑制通过Nrf2/HO-1通路对膜性肾病大鼠发挥肾脏保护作用
Xiujie Shi,Yue Shi,Meiying Chang et al.
Xiujie Shi et al.
The incidence of membranous nephropathy (MN) is gradually increasing; however, safe and effective targeted therapies are still lacking. Ferroptosis may be involved in the disease progression of MN; however, the specific pathways involved re...
CDT1 and E2F1 synergistically promote the glycolysis and progression of non-small cell lung cancer through the TPX2/AKT pathway [0.03%]
CDT1和E2F1通过TPX2/AKT途径协同促进非小细胞肺癌的糖酵解和进展
Jianfeng Tan,Leqing Zhu,Bangxian Hu et al.
Jianfeng Tan et al.
Emerging data indicate that chromatin licencing and DNA replication factor 1 (CDT1) plays an important role in several cancers. However, it remains unclear whether CDT1 is functionally indispensable in lung cancer. Here, constructing tissue...