Dihydromyricetin: A potential candidate for the treatment of cholestatic liver injury via inhibition of the NLRP3 inflammasome [0.03%]
二氢杨梅素通过抑制NLRP3炎性小体治疗胆汁淤积性肝损伤的潜力研究
Hao Zhang,Yiping Dang,Yuanjin Guo et al.
Hao Zhang et al.
Objective: Cholestatic liver injury is a hepatic disorder caused by abnormal bile acid metabolism and biliary obstruction, with limited clinical treatment options. Activation of the NLRP3 inflammasome is recognized as a k...
Downregulation of claudin-2 expression and chemoresistance by saquinavir in human lung adenocarcinoma cells [0.03%]
Sayaka Komoto,Riho Kimura,Yuta Yoshino et al.
Sayaka Komoto et al.
Claudin-2 (CLDN2) is a tight junction-associated transmembrane protein that is highly expressed in lung adenocarcinoma and contributes to chemoresistance. Here, we screened Food and Drug Administration-approved small-molecule drugs to ident...
Icariside II suppresses bladder cancer progression via endoplasmic reticulum stress-mediated autophagy and lysosomal dysfunction [0.03%]
Jinhua Wang,Kancheng He,Huiyue Qi et al.
Jinhua Wang et al.
Background: Icariside II is an active compound extracted from Herba Epimedii, a traditional Chinese medicine known for its remarkable effects in treating erectile dysfunction and arthritis. However, the specific mechanism...
Therapeutic Opportunities for Ferroptosis In Lipopolysaccharides- Induced Acute Kidney Injury; Liproxstatin-1 Versus N- Acetyl Cysteine [0.03%]
Heba F Ibrahim,Eman H Thabet,Sara Assem et al.
Heba F Ibrahim et al.
Acute kidney injury (AKI) is a fatal condition with high morbidity and mortality rates. Recent studies indicated that ferroptosis is implicated in the pathogenesis of AKI. This suggests that ferroptosis inhibitors deserve more attention as ...
Phloretin inhibits osteoclast differentiation and alleviates disuse osteoporosis through the PI3K/AKT/NF-κB pathway [0.03%]
Fanhao Wei,Bin Yang,Binjia Ruan et al.
Fanhao Wei et al.
Mechanical unloading that results from aging, prolonged bed rest, or spaceflight leads to disuse osteoporosis (DOP), a significant public health concern. However, the mechanisms underlying this condition, as well as effective therapeutic st...
Elotuzumab enhances the anti-tumor activity of Vγ9Vδ2 T cells against primary effusion lymphoma [0.03%]
Kosuke Maeda,Ryusho Kariya,Jutatip Panaampon et al.
Kosuke Maeda et al.
Primary Effusion Lymphoma (PEL) is an aggressive B-cell lymphoma with no standard treatment. Vγ9Vδ2 T cells contribute to tumor eradication but have limited cytotoxicity on their own. Elotuzumab (Elo), an anti-SLAMF7 monoclonal antibody a...
Insights into semaglutide cardiovascular research: Mechanisms, trials, and frontiers [0.03%]
塞meglutide心血管研究述评：机制、试验与前沿方向
Jiexin Zhang,Guanbin Gao,Meng He et al.
Jiexin Zhang et al.
Cardiovascular disease (CVD) remains the leading cause of global mortality, with pathophysiological alterations such as heart failure with preserved ejection fraction, diabetic cardiomyopathy, and atherosclerotic cardiomyopathy representing...
Targeted knockdown of hepatic XDH via GalNAc-siRNA alleviates hyperuricaemia and renal injury in UOX-/- mice [0.03%]
GalNAc-siRNA介导的肝脏XDH敲低缓解Uox基因敲除小鼠高尿酸血症及肾脏损伤
Ruikai Li,Yuqi Li,Chuting Zhang et al.
Ruikai Li et al.
Hyperuricaemia is a metabolic disorder characterized by elevated serum urate levels. Uric acid production primarily results from purine metabolism, with xanthine dehydrogenase (XDH) serving as a key enzyme determining uric acid synthesis. R...
Agmatine interaction with imidazoline receptor inhibits manifestation of depression-like behavior in 3-Nitropropionic Acid-induced Huntington's disease-like phenotype in rats [0.03%]
_agmatine与imidazoline受体的相互作用可抑制3-硝基丙酸诱导的类亨廷顿舞蹈病大鼠抑郁样行为的产生
Raj Katariya,Sakshi Jari,Poonam Dhaigude et al.
Raj Katariya et al.
Huntington's disease (HD)-associated depression is a prevalent psychiatric symptom affecting between one-third and over two-thirds of patients, significantly impacting their quality of life. Agmatine, a biogenic amine produced by the decarb...
Spleen-brain axis regulates myelin integrity via TGF-β1 signaling in cuprizone-induced demyelination and remyelination model [0.03%]
脾-脑轴通过TGF-β1信号调节杯rizone诱导的脱髓鞘和再髓鞘模型中的髓鞘完整性
Yi Cai,Tingting Zhu,Mingming Zhao et al.
Yi Cai et al.
Demyelination and impaired remyelination are hallmark features of many neurodegenerative and psychiatric disorders. Although central mechanisms have been widely investigated, the contribution of peripheral immune organs such as the spleen r...