Micropeptide PEP1695 mitigates lung injury in COPD mice by inhibiting epithelial-mesenchymal transition of type II alveolar epithelial cells [0.03%]
Min Zhang,Xue Zhang,Yan Zhou et al.
Min Zhang et al.
Micropeptides encoded by small open reading frames (smORFs) within long noncoding RNAs (lncRNAs) have emerged as important regulators of various biological processes. However, whether micropeptides mitigate lung tissue damage in chronic obs...
Troxerutin attenuates paclitaxel-induced cardiotoxicity through modulation of ferroptosis and GRP78/ATF6/CHOP signaling in rats [0.03%]
Yasmine M El-Naggar,Sara El Wakeel,Mina Y George et al.
Yasmine M El-Naggar et al.
Paclitaxel (PXT) is an effective chemotherapeutic agent whose clinical use is limited by serious cardiotoxic effects, including arrhythmias, myocardial infarction, and heart failure. Troxerutin (TXR) is a bioflavonoid with demonstrated card...
Therapeutic effect of rutin on Henoch-Schönlein purpura by attenuating inflammation and protection of the intestinal barrier function in rats [0.03%]
Wenwen Zhao,Minghui Ouyang,Jing Mu et al.
Wenwen Zhao et al.
Henoch-Schönlein purpura (HSP) or immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in children. Rutin is a flavonoid with anti-inflammatory and antioxidant effects. This study aimed to investigate the protective ef...
Astilbin directly targets trimethylguanosine synthase 1 to enhance telomerase activity thus alleviating pulmonary fibrosis [0.03%]
Junjie Zhao,Bin Xia,Xinyang Hu et al.
Junjie Zhao et al.
Pulmonary fibrosis (PF) is an intractable chronic interstitial lung disease with limited effective therapeutic options. Accumulating evidence suggests that astilbin (AST), a natural flavonoid isolated from traditional Chinese herbs, possess...
Neuropeptide S alleviates neuropathic pain through lateral hypothalamic orexinergic circuit in rats [0.03%]
Utkarsh P Patil,Harish M Kawade,Deepali M Pandhare et al.
Utkarsh P Patil et al.
Neuropathic pain poses a significant clinical challenge due to limited treatment options. Neuropeptide S (NPS) system is known to modulate pain and related affective states; however, the underlying mechanisms remain unexplained. NPS activat...
Neuroprotective effects of cinnamaldehyde and naltrexone on morphine-induced hippocampal neurotoxicity: Behavioral, biochemical, ultrastructural evaluations [0.03%]
Seyede Soraya Mahmoudi,Amir Abbas Farshid,Esmaeal Tamaddonfard et al.
Seyede Soraya Mahmoudi et al.
Chronic consumption of opiates such as morphine can exert serious adverse effects such as cognitive disturbances. Cinnamaldehyde has a potent neuroprotective property. The current study was targeted to explore the effect of cinnamaldehyde o...
A ferulic acid derivative FAD012 protects brain microvascular endothelial cells from H2O2-induced ferroptosis via NRF2 activation [0.03%]
Toshiya Aoyama,Meiyan Xuan,Satoshi Kitaoka et al.
Toshiya Aoyama et al.
Ferroptosis, a regulated form of necrotic cell death characterized by iron-dependent lipid peroxidation, has been implicated in blood-brain barrier (BBB) disruption during ischemia-reperfusion injury, particularly in brain microvascular end...
Citral exerts a more pronounced antinociceptive effect in obese adult male C57BL/6J mice mediated through the CB2 receptor [0.03%]
柠檬醛通过CB2受体介导在肥胖的C57BL/6J雄性小鼠中产生更显著的抗痛觉作用
Felipe Lima Dario,Maria Luiza Alves Aquino,Maycon Tavares Emílio-Silva et al.
Felipe Lima Dario et al.
Background: Obesity is a prevalent chronic disease strongly associated with pain, primarily due to low-grade systemic inflammation that sensitizes nociceptive neurons. ...
The Pulmonary Circadian Rhythms (Diurnal Rhythms) Role of the Bmal1/Per2 Axis in Mitigating Ventilator-Induced Lung Injury and Fibrosis through Nrf2 Antioxidant Pathway Activation [0.03%]
BMAL1/PER2轴通过激活Nrf2抗氧化途径减轻机械通气诱导的肺损伤和纤维化的作用
De-Chao Li,Ming-Hui Wu,Hong-Yan Ruan
De-Chao Li
Backgrounds: While lung-protective ventilation strategies are standard care, effective adjunctive pharmacotherapies for ventilator-induced lung injury (VILI) remain lacking. Disruption of circadian (diurnal) rhythms is im...
Ibogalogs and their pyridoindole homologs activate or inhibit the 5-HT2B receptor by modulating the distance between transmembrane segments TM3 and TM6 in the orthosteric site [0.03%]
伊博加因类及其吡啶并吲哚类似物通过调节正构位点跨膜区TM3和TM6之间的距离来激活或抑制5-HT2B受体
Hugo R Arias,Deborah Rudin,Xintong Ren et al.
Hugo R Arias et al.
Previous behavioral studies showed that ibogalogs induce beneficial effects in various neurological animal paradigms (see Introduction). Thus, the binding, functional, and mechanistic characterization of ibogalogs and their pyridoindole hom...