Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling [0.03%]
补骨脂通过HIF-1α介导的NF-κB信号抑制作用来缓解破骨细胞生成及卵巢切除术引起的骨质流失
Shu-Wen Shi,Yi-Fei Fu,Xian Wu et al.
Shu-Wen Shi et al.
Background: Osteoporosis is a common metabolic bone disease characterized by an imbalance in bone remodeling, which leads to elevated bone resorption due to enhanced osteoclastic activity. Current anti-resorptive therapie...
Chorionic villous mesenchymal stem cell-derived exosomes promote trophoblasts proliferation and invasion through delivery miR-135b-5p targeting TXNIP via the β-catenin pathway [0.03%]
绒毛基质干细胞来源的外泌体通过Wnt/β-catenin信号传导途径递送miR-135b-5p靶向TXNIP促进滋养细胞增殖和侵袭
Guoqiang Gao,Yijing Chu,Wenting Li et al.
Guoqiang Gao et al.
Human chorionic villous mesenchymal stem cells (CV-MSCs) are a promising and effective treatment for tissue injury. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). This work aimed...
Clofibrate inhibits tumor immune escape by increasing macrophage phagocytosis [0.03%]
氯贝特通过增加巨噬细胞吞噬作用抑制肿瘤免疫逃逸
Huijie Wang,Yelei Wang,Yinghan Li et al.
Huijie Wang et al.
The CD47/SIRPα signaling axis functions as a critical innate immune checkpoint, enabling tumor immune escape. Although the PPARα agonist clofibrate is known to influence cancer cell metabolism, proliferation, and inflammatory responses, i...
Nstpbp5185, a novel benzimidazole derivative, suppresses PDGF signaling and reduces neointimal hyperplasia following vascular injury [0.03%]
一种新型苯并咪唑衍生物Nstpbp5185通过抑制血小板源性生长因子信号通路减少血管损伤后的内膜增生
Ming-Jen Hsu,Shih-Hsin Hsiao,Jin-Cherng Lien et al.
Ming-Jen Hsu et al.
Restenosis remains a significant clinical challenge following percutaneous coronary interventions such as angioplasty and stenting. Despite advances in techniques and drug-eluting stents, neointimal hyperplasia and vessel re-narrowing still...
Deacetylasperulosidic acid methyl ester attenuates liver fibrosis by modulating the SCFAs-Wnt/β-catenin signaling axis [0.03%]
脱乙酰基阿斯珀鲁西迪酸甲酯通过调节SCFAs-Wnt/β-catenin信号轴来缓解肝纤维化
Cheng Wang,Ting Jiang,Lingli Zheng et al.
Cheng Wang et al.
Liver fibrosis is a common pathological consequence of chronic liver injury, characterized by excessive extracellular matrix deposition, hepatocellular damage and persistent inflammation, which may progress to cirrhosis or hepatocellular ca...
TAK-242 alleviates neuroinflammation and poststroke cognitive impairment by targeting the TLR4/SYK/NF-κB pathway in a cerebral ischemia/reperfusion rat model [0.03%]
TAK-242通过靶向TLR4/SYK/NF-κB途径缓解脑缺血再灌注大鼠模型的神经炎症和卒中后认知障碍
Hui Zhang,Qimei Yun,Zezhou Xu et al.
Hui Zhang et al.
Neuroinflammation plays an essential role in neurological dysfunction in cerebral ischemia and reperfusion injury. Understanding the molecular network associated with neuroinflammation will provide potential targets for the neuroprotective ...
Neutrophil extracellular traps (NETs) extrusion in infection and diseases: A hallway for diagnosis and prognosis [0.03%]
感染和疾病中的中性粒细胞胞外诱捕网（NETs）释放：一个用于诊断和预后的通道
Muhammad Hassan Nasir,Aneeq Ur Rehman,Marina Bt Yusoff et al.
Muhammad Hassan Nasir et al.
A novel mechanism, NETosis, extrudes neutrophil extracellular traps (NETs) and empowers neutrophils to trap microbial pathogens and eliminate them through antimicrobial proteins. NETs are reported in microbial pathogenesis and are associate...
Chrysophanol attenuates breast cancer angiogenesis through blocking VEGFA/VEGFR2/ERK activation via inhibiting ACE2 ubiquitination [0.03%]
大黄素通过抑制ACE2泛素化阻断VEGFA/VEGFR2/ERK激活从而抑制乳腺癌血管生成
Tong Zhao,Luying Xu,Wenjie Huang et al.
Tong Zhao et al.
Background: Breast cancer progression depends on abnormal angiogenesis, driven by VEGF/VEGFR2/ERK and inhibited by Angiotensin-Converting Enzyme 2 (ACE2). Chrysophanol (CHR) shows anti-breast cancer efficacy, but its mech...
β-sitosterol attenuates hyperglycemia induced apoptosis through modulating NF-κB/NLRP3 in renal proximal tubule epithelial cell line [0.03%]
β-谷固醇通过调节NF-κB/NLRP3减轻高糖诱导的肾近端小管上皮细胞凋亡
Abdulrahman Alasmari,Chellasamy Panneerselvam
Abdulrahman Alasmari
Diabetic nephropathy is the primary cause of chronic kidney disease worldwide, impacting more than 107 million people. Hyperglycemia-induced apoptosis of renal proximal tubule epithelial cells through NF-κB pathway activation constitutes a...
The novel therapeutic strategy of myricetin/chitooligosaccharide/astaxanthin, as potent multi-target-directed ligands for the potential treatment of Alzheimer's disease with comorbid depression [0.03%]
茋类化合物RU-026通过抑制巨噬细胞中TREM2介导的炎症信号传导减轻阿尔茨海默病中的抑郁样行为
Songbin He,Zhiqi Lin,Xiaojing Zhou et al.
Songbin He et al.
Objective: The mixed particles of Myricetin (MYR)/Chitooligosaccharide (COS)/Astaxanthin (AST) had not study to therapeutic effects on Alzheimer's disease (AD) combined with depression. In this study, the mixed particles ...