The E3 ubiquitin ligase midline 1 reduces the intrinsic antibacterial activity of hepatocytes by promoting HRG degradation during sepsis [0.03%]
E3泛素连接酶中线1通过促进HRG在脓毒症期间的降解来降低肝细胞的固有抗菌活性
Junjie Shu,Wei Ma,Haoru Liu et al.
Junjie Shu et al.
Aims: The ubiquitination system in hepatocytes and its direct role in antibacterial defense during sepsis remain poorly understood. This study investigated the mechanism by which the E3 ubiquitin ligase Midline 1 (Mid1) r...
Coxsackievirus B3 suppresses oral squamous cell carcinoma by inducing ferroptosis through the circ_0010074/miR-214-3p/GPX4 pathway [0.03%]
环状RNA circ_0010074/miR-214-3p/GPX4轴诱导的铁死亡在柯萨奇病毒B3抑制舌鳞癌中的作用机制研究
Zhao Bowen,Li Jianhao,Li Zhengmiao et al.
Zhao Bowen et al.
Oral squamous cell carcinoma (OSCC) exhibits aggressive invasion with limited treatment options. This study investigates the oncolytic potential of coxsackievirus B3 (CVB3) against OSCC and explores its ability to induce ferroptosis. Gene S...
Corrigendum to "Moderate mechanical strain and exercise reduce inflammation and excessive autophagy in osteoarthritis by downregulating mitofusin 2" [Life Sci. 332 (2023) 122020] [0.03%]
关于“中度机械拉伸和运动通过下调线粒体融合蛋白2减少骨关节炎中的炎症和过度自噬”的勘误[生命科学期刊第332卷(2023年)122020号论文]
Xiaofeng Deng,Haoran Xu,Xiaoxia Hao et al.
Xiaofeng Deng et al.
Published Erratum
Life sciences. 2025 Dec 17:124147. DOI:10.1016/j.lfs.2025.124147 2025
miR-30a-5p preserves cardiac homeostasis by reprogramming metabolic checkpoints in hypertrophic cardiomyopathy [0.03%]
miR-30a-5p通过重新编程肥厚型心肌病中的代谢检查点来维持心脏稳态
Xiao-Cheng Zhang,Chan Wu,Yun-Da Li et al.
Xiao-Cheng Zhang et al.
Emerging evidence has established the regulatory role of miR-30a-5p in myocardial infarction through multifaceted mechanisms. However, its functional significance in pathological cardiac hypertrophy remains incompletely elucidated. This stu...
Tirzepatide counteracts brown adipose tissue whitening, inflammation, and mitochondrial dysfunction in estrogen-deficient obese diabetic mice [0.03%]
tirzepatide干预可对抗雌激素缺乏的肥胖糖尿病小鼠中的棕色脂肪组织白色化、炎症和线粒体功能障碍
Julie Oliveira A Bittencourt,Ilitch A Marcondes-de-Castro,Thatiany Souza Marinho et al.
Julie Oliveira A Bittencourt et al.
This study investigated the therapeutic potential of tirzepatide, a dual GIP/GLP-1 receptor agonist, in a mouse model combining obesity, type 2 diabetes, and estrogen deficiency. Four groups were initially established and maintained for 12 ...
LSKL mitigates dehydroepiandrosterone-induced apoptosis and oxidative stress by THBS1/PI3K/AKT pathway in rat granulosa cells [0.03%]
LSKL通过THBS1/PI3K/AKT信号通路缓解DHEA诱导的颗粒细胞凋亡和氧化应激
Lu Zhang,Chao Wang,Yu Liu et al.
Lu Zhang et al.
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder characterized by abnormalities in the inflammation-like ovulatory process. Elevated thrombospondin-1 (THBS1) is associated with these disruptions, but the impact ...
HDAC11 deficiency improves muscle phenotype in a Duchenne muscular dystrophy murine model by reducing inflammation and fibrosis [0.03%]
组蛋白脱乙酰酶11缺乏通过减少炎症和纤维化改善杜氏肌营养不良小鼠模型的肌肉表型
Renato Odria,Alexandra Mercado-Amarilla,Carolina Soler-Botija et al.
Renato Odria et al.
Duchenne muscular dystrophy (DMD) is a devastating genetic disorder caused by mutations in the dystrophin gene, which encodes for an essential protein to maintain muscle integrity. Loss of dystrophin leads to progressive muscle degeneration...
Hypoxia-activated HSP90AA1/STUB1 axis promotes acute pancreatitis via necroptosis protein stabilization [0.03%]
缺氧激活的HSP90AA1/STUB1轴通过稳定坏死蛋白促进急性胰腺炎发病
Tian-Jiao Song,Chen-Shi-Yu Zhu,Jin-Quan Luo et al.
Tian-Jiao Song et al.
Acute pancreatitis (AP) is a prevalent inflammatory disorder with high mortality in severe cases. Although necroptosis-driven inflammatory cascades significantly contribute to poor prognosis, effective therapeutic interventions remain limit...
NIK suppresses AKT/ACLY pathway-mediated lipogenesis in liver by stabilizing INPP5B during chronic ethanol exposure [0.03%]
尼可culenin通过稳定INPP5B来抑制慢性酒精暴露下肝脏中AKT/ACLY通路介导的脂质合成
Wen Zhang,Manzhi Qi,Xiaojing Zhao et al.
Wen Zhang et al.
Background: Hepatic steatosis is a hallmark of alcohol-associated liver disease (ALD) and interacts with hepatic inflammation to drive disease progression. NF-κB-inducing kinase (NIK) has been established as a bridge lin...
Gene editing of JNK alleviates sodium iodate-induced retinal degeneration in mice [0.03%]
基因编辑JNK缓解鼠碘酸钠致视网膜退行性病变
Lei Tao,Danxue He,Yuling Chen et al.
Lei Tao et al.
Purpose: Dry age-related macular degeneration (dry AMD) still lacks effective treatment strategies due to its complex mechanisms. Although c-Jun N-terminal kinase (JNK) signaling has been reported to be associated with re...