Pirfenidone ameliorates dexamethasone-induced steatohepatitis and vascular resistance in rats [0.03%]
吡非尼酮改善地塞米松诱导的实验大鼠肝脂肪变性及其血管阻力作用研究
Abdullah Q Alsaedi,Manar A Nader,Dalia H El-Kashef et al.
Abdullah Q Alsaedi et al.
In clinics, glucocorticoids (GC) are frequently recommended as immunosuppressive and anti-inflammatory medications. The side effects of GC are the main concerns, which mostly include insulin resistance (IR), vascular changes, and fatty live...
TRPV2 protects dopaminergic neurons via ferroptosis inhibition in Parkinson's disease [0.03%]
TRPV2通过抑制铁死亡保护帕金森病中的多巴胺能神经元
Ying Chen,Junzhen Jia,Yan Qin et al.
Ying Chen et al.
Aims: Ferroptosis, the cell death induced by iron accumulation, contributes to the pathogenesis of Parkinson's disease (PD). While transient receptor potential vanilloid 2 (TRPV2) is known to mediate pathological processe...
Sirtuin 1 inhibits NLRP3 inflammasome activation through protein-protein interaction [0.03%]
Sir2_like_deacetylase_sirtuin-1通过蛋白质间相互作用抑制NLRP3炎性小体活化
Li-Chun Ho,Yi-Ling Tsang,Hsiao-Chien Hung et al.
Li-Chun Ho et al.
Sirtuin 1 (SIRT1) is known to suppress NLRP3 inflammasome activation via NF-κB inhibition, but its role in inflammasome assembly remains unclear. Here, using a HEK293T reconstitution system, we show that SIRT1 directly interacts and co-loc...
Drug repurposing reveals Fmoc-l-leucine as an adipose thermogenesis activator in cold-exposed mice by targeting PPARγ/UCP1 [0.03%]
药物再利用发现Fmoc-l-亮氨酸通过靶向PPARγ / UCP1激活冷暴露小鼠的脂肪产热作用
Mingjie Feng,Guangyan Jia,Qingyu Li et al.
Mingjie Feng et al.
Cold-induced injuries, such as hypothermia and frostbite, pose significant health risks and have limited therapeutic options. Drug repurposing using integrated bioinformatics approaches offers an effective strategy for identifying potential...
Aberrant interferon-γ signaling disrupts trophoblast invasion via IDO1/AHR signaling and metabolic reprogramming associated with recurrent pregnancy loss [0.03%]
干扰素-γ信号异常通过IDO1/AHR信号和代谢重编程途径影响胎盘滋养细胞侵袭与反复流产相关性
Linwei Zhou,Lijun Yang,Jinya Zhang et al.
Linwei Zhou et al.
Aims: Recurrent pregnancy loss (RPL) is a multifactorial reproductive disorder in which immune dysregulation has been increasingly implicated. This study aimed to elucidate how interferon-γ (IFN-γ) signaling affects tro...
Ferroptosis in plants: Regulatory mechanisms and potential applications from plant physiology to human diseases [0.03%]
植物铁死亡：从植物生理到人类疾病的调控机制和潜在应用
Fang Wang,Ruifang Dang,Yanjie Yang et al.
Fang Wang et al.
Ferroptosis is a novel form of regulated cell death characterized by iron-dependent lipid peroxidation, which is mediated by multi-pathway cascades involving dysregulated iron metabolism, polyunsaturated fatty acids (PUFAs) oxidation, and i...
STC-1 improves scar remodeling and is associated with PI3K/AKT signaling and immune modulation [0.03%]
STC-1促进瘢痕重塑并与PI3K/AKT信号和免疫调节相关
Xiao-Ying Lin,Zhang-Rui Wu,Yi Wang et al.
Xiao-Ying Lin et al.
Background: Dysregulation of the wound remodeling phase can lead to excessive scar formation, which may cause functional impairment and aesthetic distress. However, effective strategies to improve tissue repair outcomes r...
Screening strategy using a filamentous fungus model to repurpose drugs for mitochondrial complex I deficiencies [0.03%]
一种筛选策略：利用丝状真菌模型来重新定向药物用于线粒体复合物I缺陷性疾病治疗
Carole H Sellem,Nolwenn Bounaix,Mathilde Logerais et al.
Carole H Sellem et al.
Aim: This study aimed to repurpose FDA-approved drugs for the treatment of mitochondrial complex I diseases. Materials and methods: The...
Dapagliflozin ameliorates myocardial ischemia/reperfusion injury by modulating EGFR signaling and targeting NCOA4-mediated ferritinophagy [0.03%]
达格列净通过调节EGFR信号传导并靶向NCOA4介导的铁死亡自噬来改善心肌缺血/再灌注损伤
Peng Yu,Jitao Ling,Feng Chen et al.
Peng Yu et al.
Background: SGLT2 inhibitor dapagliflozin (Dapa) has gained increasing attention in the treatment of myocardial ischemia-reperfusion injury (IRI). However, the mechanism of action of the cardiovascular benefits of Dapa is...
Ezrin (EZR) promotes breast cancer progression and drug resistance: Molecular mechanisms involving STAT3 activation and TPM3 interaction [0.03%]
ezrin(EZR)通过激活STAT3和TPM3互作促进乳腺癌发生发展与耐药的分子机制研究
Hongshan Huang
Hongshan Huang
Aims: To define the clinical relevance and mechanistic role of Ezrin (EZR) in breast cancer progression, metastasis, and paclitaxel resistance. Materials ...