Brown adipose tissue-derived neuregulin 4 attenuates hyperlipidemia and atherosclerosis by activating the hepatic ErbB4/AHR/CYP1A1 signaling pathway [0.03%]
棕色脂肪组织来源的neuregulin 4通过激活肝脏ErbB4/AHR/CYP1A1信号通路缓解高脂血症和动脉粥样硬化
Yulong Yang,Yue Hu,Xiqiu Wu et al.
Yulong Yang et al.
Hyperlipidemia is a major contributor to atherosclerotic cardiovascular disease, yet effective therapeutic strategies targeting lipid metabolism remain limited. Recent evidence has established brown adipose tissue (BAT) as an endocrine orga...
Steroidal alkaloid H89712 ameliorates neuroinflammation and memory deficits: Enhancing cerebral oxidative phosphorylation in APP/PS1 mice [0.03%]
类固醇生物碱H89712改善神经炎症和记忆缺陷：通过提高APP / PS1小鼠脑氧化磷酸化水平来实现
Liping Jiang,Zhuo Zhang,Xin Luo et al.
Liping Jiang et al.
Aims: Alzheimer's disease (AD) poses a major health challenge with limited therapeutic options. This study aimed to investigate the anti-AD potential and underlying mechanism of a novel steroidal alkaloid, H89. ...
Targeting PARP1-dependent parthanatos in Alzheimer's disease: Mechanisms and therapeutic opportunities [0.03%]
靶向阿尔茨海默病中PARP1依赖性的Parthanatos：机制和治疗机会
Ayman Ali Mohammed Alameen,Hayder M Al-Kuraishy,Ahmed M Abdelaziz et al.
Ayman Ali Mohammed Alameen et al.
Alzheimer's disease (AD) is the predominant cause of dementia globally. This review clarifies the dual function of poly(ADP-ribose) polymerase 1 (PARP1) in AD pathogenesis, emphasizing its role in mediating parthanatos, a unique caspase-ind...
The emerging role of NAT10-mediated N4-acetylcytidine modification of RNA in bone diseases: Current frontiers and future challenges [0.03%]
NAT10介导的RNA N4-乙酰基胞苷修饰在骨疾病中的作用及其面临的挑战
Gan Luo,Zhihan Ning,Hong Yang
Gan Luo
Aims: To review the biosynthesis, regulatory mechanisms, and functional roles of N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) RNA modification in bone and joint diseases, and to evaluate its therapeuti...
Overactivated bradykinin-B2 receptor promotes type a aortic dissection by inducing endothelial dysfunction: Therapeutic effect of icatibant [0.03%]
活化过强的缓激肽B2受体通过诱导内皮细胞功能障碍促进A型主动脉夹层：Icatibant的治疗作用
Shuanglei Zhao,Lei Li,Qianxian Li et al.
Shuanglei Zhao et al.
Aims: Type A aortic dissection (TAAD) is a life-threatening cardiovascular emergency for which no effective pharmacological therapy currently exists. Elevated bradykinin (BK) has been identified as an independent predicto...
Gut microbiota and metabolites in remodeling the tumor microenvironment and regulating immunotherapeutic efficacy in colorectal cancer [0.03%]
肠道菌群及其代谢产物通过重塑结直肠癌肿瘤微环境和调节免疫治疗效应影响疾病进展和预后
Meichen Gu,Zhuo Wang,Fuxue Huang et al.
Meichen Gu et al.
Aims: Immune checkpoint inhibitors (ICIs) benefit patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), but efficacy remains limited in proficient mismatch repair/mi...
A CD31-derived cytoplasmic ITIM peptide enhances epidermal and dermal regeneration in cutaneous wound repair [0.03%]
一种CD31衍生的细胞内ITIM肽促进皮肤伤口修复中的表皮和真皮再生
Aeseon Yoon,Jung-Hwa Han,Jeongseon Oh et al.
Aeseon Yoon et al.
Aims: Chronic wounds affect millions globally, yet current therapies lack the ability to coordinate epithelial, dermal, and immune repair processes. We investigated whether a 16-amino acid immunoreceptor tyrosine-based in...
Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses [0.03%]
短QT间期综合征3型基于诱导多能干细胞源性心肌细胞等基因模型揭示电生理特征及药物反应差异
Min Woo Kim,Jeong Hwan Park,Myeonghee Lee et al.
Min Woo Kim et al.
Short QT syndrome (SQTS) is a genetically inherited autosomal dominant cardiac channelopathy associated with paroxysmal atrial and ventricular fibrillation, syncope, and sudden cardiac arrest. Although SQTS is a well-known arrhythmogenic di...
RPS20 phosphorylation acts as a molecular switch to integrate inflammatory and oxidative stress signals in sepsis [0.03%]
RPS20磷酸化作为分子开关介导脓毒症状态下炎症和氧化应激信号的整合
Gang Yuan,Qudi Qiao,Ying Li et al.
Gang Yuan et al.
Sepsis is a life-threatening condition driven by dysregulated inflammation and oxidative stress, yet the role of ribosomal proteins in integrating these pathological signals remains poorly understood. Here, we identify ribosomal protein S20...
Local lymphatic circulation disorder: A key promoter of tissue inflammation and organ fibrosis [0.03%]
局部淋巴循环障碍：组织炎症和器官纤维化的关键促进因素
Xun Wu,Chunjun Liu
Xun Wu
The lymphatic system serves as a vital vascular network essential for maintaining fluid homeostasis, macromolecule and lipid transport, and modulating immune responses. While traditional research has predominantly focused on peripheral lymp...