Temporal control of decidual inflammation by HOXA10 is essential for implantation and its dysregulation is associated with early pregnancy loss [0.03%]
HOXA10调控蜕膜炎症对植入至关重要且其失调与早期妊娠丢失相关
R Sharma,B Negi,R Ponsankaran et al.
R Sharma et al.
Background: Successful implantation requires tightly regulated endometrial inflammation. While initial inflammatory signaling is essential for implantation, persistent inflammation is detrimental to placentation and pregn...
FOSL2+ macrophages drive pro-inflammatory phenotype via miR-92a-3p/FOSL2/NF-κB axis to mediate endothelial cell injury in aortic dissection [0.03%]
FOSL2+巨噬细胞通过miR-92a-3p/FOSL2/NF-κB轴驱动促炎表型介导主动脉夹层内膜炎症反应及血管损伤
Zhenpeng Yuan,Ruihan Chen,Rong Fan et al.
Zhenpeng Yuan et al.
Background: In aortic dissection, macrophages play a critical role; however, the impact of macrophages on vascular endothelial cells remains unclear. Meth...
Rehana Basri,Hayder M Al-Kuraishy,Mohamed N Fawzy et al.
Rehana Basri et al.
Alzheimer's disease (AD) is a significant public health threat, and current therapeutic approaches provide only minimal symptomatic benefit without slowing its progression. This review covers evidence for the expanding involvement of pituit...
Lingli Huang,Yanshi Wang,Dai Li et al.
Lingli Huang et al.
Aims: ASGR1 is a hepatocyte surface glycoprotein receptor that plays a crucial role in maintaining liver homeostasis. This study investigates its role in acute liver injury (ALI) and whether it is associated with the regu...
Neurobiology of TRPM channels in pain processing: Current advances and future directions [0.03%]
疼痛处理中TRPM通道的神经生物学：当前进展和未来方向
Madhuri Dhande,Deepak Chouhan,Nivedita Verma et al.
Madhuri Dhande et al.
Chronic pain affects 7-10 % of the global population and remains a major clinical and socioeconomic burden. Transient receptor potential melastatin (TRPM) channels are emerging as key modulators of somatosensory processing and pain pathophy...
Butyrate ameliorates lung inflammation in chronic obstructive pulmonary disease in association with the regulation of histone lactylation: A mechanistic study [0.03%]
丁酸通过调节组蛋白乳酰化改善慢性阻塞性肺疾病的肺部炎症：一项机制研究
Min Jiang,Qin Jiang,Haibo Wu et al.
Min Jiang et al.
Aims: This study investigates the role and mechanism of butyrate in modulating lung inflammation in a murine model of chronic obstructive pulmonary disease (COPD). ...
The Novel Triad of Atherosclerosis, ACE2, and Dysbiosis: A literature Review [0.03%]
动脉粥样硬化、ACE2和菌群失调三联征的文献回顾
V Prabhakaran,V Poovizhi,Vipin Kumar Verma et al.
V Prabhakaran et al.
Atherosclerosis, a chronic inflammatory disease and the leading cause of myocardial infarction and stroke, is marked by lipid accumulation, arterial stiffening, and plaque formation initiated by endothelial dysfunction. Despite its well-und...
YAP inactivated by NF-κB p65, can protect against colonic epithelial cell pyroptosis in ulcerative colitis via transcriptionally regulating NLRP3 [0.03%]
YAP通过转录调控NLRP3抑制NF-κB p65介导的溃疡性结肠炎(colitic)黏膜上皮细胞焦亡中
Mengmeng Xu,Pianpian Xia,Su Wang et al.
Mengmeng Xu et al.
Aims: The aberrant activation of the intestinal mucosal immune system is a critical driver of inflammatory injury in ulcerative colitis. Emerging evidence implicates pyroptosis, a pro-inflammatory programmed cell death, p...
Modulating MiR-350/Akt/mTOR/beclin1 signaling by nitazoxanide ameliorates bleomycin-induced pulmonary fibrosis in a wistar rat model [0.03%]
硝唑尼德通过调节MiR-350/Akt/mTOR/beclin1信号通路改善韦氏大鼠模型中bleomycin诱导的肺纤维化
Eman M Elbaz,Yara Shawky,Amina A S Abdel Rahman et al.
Eman M Elbaz et al.
Aims: Pulmonary fibrosis (PF) is a destructive, inflammatory intersectional lung disease that has lethal consequences. Autophagy, a cellular homeostasis sustaining system, has shown a vital function in PF progression. Nit...
UAMC-3203 attenuates aortic dissection by targeting ferroptosis-mediated vascular smooth muscle cell loss [0.03%]
UAMC-3203通过靶向铁死亡介导的血管平滑肌细胞丢失来缓解主动脉夹层
Wenjie Fu,Xinyu Li,Linlong Guo et al.
Wenjie Fu et al.
Aortic dissection (AD), which is a lethal cardiovascular emergency, lacks effective pharmacological interventions. The pathogenesis of AD is complex, and the loss of vascular smooth muscle cells (SMCs) is considered to be a key pathological...