Estrogen receptor-autophagy axis protects the heart, aorta and kidneys during perimenopausal aging: Evidence from human cohort and mouse experiments [0.03%]
雌激素受体-自噬轴在围绝经期保护心脏、主动脉和肾脏：来自人类队列和小鼠实验的证据
Xiuting Xiang,Weizhou Jiang,Praneetha Palasuberniama et al.
Xiuting Xiang et al.
Aim: The gradual decline in estrogen levels during perimenopause is strongly associated with an increased risk of metabolic and cardiovascular diseases. However, the specific relationship and underlying mechanisms remain ...
Linling Fan,Yijing Liao,Zhihong Wang et al.
Linling Fan et al.
Introduction: γ-Aminobutyric acid (GABA), a classical neurotransmitter, also regulates skeletal muscle-an endocrine organ secreting irisin. This FNDC5-derived myokine induces white adipose tissue browning, augmenting the...
The emerging role of decorin in pancreatic islet biology: From development to degeneration [0.03%]
角蛋白二聚体在胰岛生物学中的作用：从发育到退变
Huanjing Bi,Ruiyang Ma,Zuhan Chen et al.
Huanjing Bi et al.
Decorin, a small leucine-rich proteoglycan, has emerged as a multifunctional signaling molecule with critical implications for pancreatic islet biology beyond its canonical role in extracellular matrix organization. Despite extensive charac...
Retraction notice to "Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression" [Life Sci. 186 (2017) 125-132] [0.03%]
撤稿： baicalin可能通过抑制il-33表达缓解葡聚糖硫酸钠致慢性溃疡性结肠炎的炎症浸润[life sci. 186 (2017) 125-132]
Cheng-Liang Zhang,Si Zhang,Wen-Xi He et al.
Cheng-Liang Zhang et al.
Retraction notice to "A novel approach to bladder dysfunction induced by bladder outlet obstruction: Low-intensity extracorporeal shock wave therapy promotes bladder regeneration" [Life Sci. 378 (2025) 123799] [0.03%]
撤稿通知：“膀胱出口梗阻引起的膀胱功能障碍的新方法：低强度体外冲击波治疗促进膀胱再生”[Life Sci. 378 (2025) 123799]
Sheng-Tang Wu,Tai-Jui Juan,Jian-He Lu et al.
Sheng-Tang Wu et al.
Advances in AI for predicting pharmacological properties of natural medicines [0.03%]
人工智能在预测天然药物药理性质方面的进展
Tianyu Xu,Yuemiao Xu,Jinger Zhang et al.
Tianyu Xu et al.
Artificial intelligence (AI), which includes machine learning (ML) and deep learning (DL), has become an important tool in drug development. An increasing number of studies have discovered pharmacologically active compounds in natural produ...
Adiponectin receptor agonist, AdipoRon, reduces the growth of prostate cancer cells and patient-derived organoids [0.03%]
腺苷酮受体激动剂AdipoRon可抑制前列腺癌细胞及患者来源类器官的生长
Francielle C Mosele,Ana Luiza Romano Gabriel,Nilton José Dos Santos et al.
Francielle C Mosele et al.
Low adiponectin levels in obese men are associated with an incidence of aggressive prostate cancer (PCa). Despite significant advances in PCa treatment, some cases become resistant, making the development of new therapies crucial. An altern...
Adventitial fibroblast-derived NAMPT is associated with vascular remodeling in erythropoietin-induced abdominal aortic aneurysm [0.03%]
促红细胞生成素诱导的腹主动脉瘤中 adventitial 成纤维细胞源性 NAMPT 与血管重塑有关
Xinyi Lyu,Shuqin Ding,Chongqing Jiang et al.
Xinyi Lyu et al.
Abdominal aortic aneurysm (AAA) remains a life-threatening condition with limited pharmacological interventions. While erythropoietin (EPO) has been implicated in AAA pathogenesis, its cell-type-specific effects on nicotinamide phosphoribos...
O-GlcNAcylation stabilizes c-MYC to upregulate xCT and inhibit ferroptosis in ovarian cancer [0.03%]
O-葡萄糖酸化通过上调xCT抑制铁死亡来稳定c-MYC在卵巢癌中的作用
Ying Tang,Yaru Zhang,Xinmei Chen et al.
Ying Tang et al.
Aims: Ovarian cancer (OV) is one of the most prevalent and life-threatening malignancies among women worldwide. Resistance to conventional therapies poses a major challenge in OV treatment. Ferroptosis, a type of programm...
RUVBL1-mediated mTORC1 activation drives tumour progression and immune evasion for oral squamous cell carcinoma [0.03%]
RUVBL1介导的mTORC1激活驱动口腔鳞状细胞癌的肿瘤进展和免疫逃逸
Xinpei Wang,Zuxuan Zhao,Fengyang Jing et al.
Xinpei Wang et al.
Background and aims: Oral squamous cell carcinoma (OSCC) is a prevalent head and neck malignancy for which surgical resection remains the primary therapeutic approach. Although immunotherapy, particularly immune checkpoin...