Cabozantinib induces NLRP3-CASP1-GSDMD-dependent pyroptosis in hepatocellular carcinoma [0.03%]
卡博替尼通过NLRP3-CASP1-GSDMD依赖性细胞焦亡途径抑制肝癌进展
Li Lin,Chiun Hsu,Chia-Lang Hsu et al.
Li Lin et al.
Aims: Cabozantinib is a multi-target tyrosine kinase inhibitor approved for second-line treatment of advanced hepatocellular carcinoma (HCC). While its antiangiogenic and antiproliferative effects are well known, its immu...
Sinapic acid balances the excitatory and inhibitory neurotransmitter systems to mitigate post-traumatic stress disorder-like behaviors [0.03%]
芥子酸通过平衡兴奋性及抑制性神经递质系统来缓解创伤后应激障碍样行为
Chang Hyeon Kong,Keontae Park,Ju Eun Han et al.
Chang Hyeon Kong et al.
Post-traumatic stress disorder (PTSD) is a mental illness that can occur in individuals who have experienced trauma. Sinapic acid has been reported to be effective for anxiety as a GABAA receptor agonist, and has been reported to improve co...
Sinomenine ameliorates myocardial ischemia/reperfusion injury by inhibiting mitochondrial oxidative stress-mediated PANoptosis and ferroptosis via α7nAChR [0.03%]
延胡索碱通过α7nAChR抑制线粒体氧化应激介导的PANoptosis和铁死亡改善心肌缺血再灌注损伤
Jia-Rong Yang,Fu-Qin Tan,Chen-Jie Cheng et al.
Jia-Rong Yang et al.
Aims: To elucidate the cardioprotective effect of sinomenine (SIN) against myocardial ischemia/reperfusion injury (MIRI) and to investigate the role of the α7 nicotinic acetylcholine receptor (α7nAChR) and its downstrea...
Retraction notice to "Effectiveness of mesenchymal stem cell-seeded onto the 3D polylactic acid/polycaprolactone/hydroxyapatite scaffold on the radius bone defect in rat" [Life Sci. 257 (2020) 118038] [0.03%]
有关“载有间充质干细胞的三维聚乳酸/聚己内酯/羟基磷灰石支架对大鼠桡骨缺损的影响”的撤稿通知[生命科学，257（2020）118038]
A Oryan,S Hassanajili,S Sahvieh et al.
A Oryan et al.
Minocycline-induced microglial remodeling restores hippocampal NMDA-dependent synaptic plasticity and reduces anxiety-like behavior in juvenile rats with temporal lobe epileptogenesis [0.03%]
多西环素诱导的小胶质细胞重塑可恢复青少年颞叶癫痫发作模型大鼠海马NMDA依赖性突触可塑性并减少焦虑样行为
Tatiana Y Postnikova,Georgy P Diespirov,Alexandra V Griflyuk et al.
Tatiana Y Postnikova et al.
Microglial activation and neuroinflammation are recognized as key drivers of synaptic dysfunction in temporal lobe epilepsy (TLE), yet the causal mechanisms linking specific microglial phenotypes to neuronal hyperexcitability remain poorly ...
Ameliorating effect and mechanism of p-coumaric acid liposome on cognitive dysfunction and mitochondrial damage under intermittent hypoxia [0.03%]
间歇低氧下阿魏酸脂质体改善认知功能障碍及线粒体损伤的作用及其机制研究
Yan-Zi Liang,Meng-Zhen Jiang,Xue-Ting Xu et al.
Yan-Zi Liang et al.
Aims: Alzheimer's disease (AD) has become a global public health problem. Mitochondrial dysfunction contributes to AD pathogenesis, and adequate oxygen supply is essential to maintain mitochondrial homeostasis. P-coumaric...
Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis [0.03%]
压缩应力通过Piezo1/YAP-TEAD/NLRP3轴诱导软骨终板退变
Tong Cao,Fushuai Peng,Wei Wang et al.
Tong Cao et al.
Aims: To investigate the potential mechanisms by which compressive stress induces degeneration of cartilage endplate, and to elucidate the specific roles of mechanosensitive protein Piezo1, YAP, and NLRP3 in this process....
Mitochondrial function of peripheral lymphocytes: role on multiple sclerosis clinical subtypes [0.03%]
外周淋巴细胞的线粒体功能：在多发性硬化症临床亚型中的作用
Adela González-Jiménez,Paloma de Heras-Pino,Alba Moreno-Jerez et al.
Adela González-Jiménez et al.
Aims: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of unknown etiology, resulting in unmet therapeutic needs. Symptoms heterogeneity and incomplete mechanistic understanding hinder effective pat...
Risk stratification using inflammatory and metabolic biomarkers: A multi-cohort predictive study of mortality in atherosclerotic cardiovascular disease [0.03%]
利用炎症和代谢生物标志物进行风险分层：动脉粥样硬化性心血管疾病的多队列死亡率预测研究
Xiao Li,Qingyue Zeng,Xiaoyu Zhang et al.
Xiao Li et al.
Background: The pathological process of atherosclerotic cardiovascular disease (ASCVD) involves complex interactions between metabolic dysregulation and inflammatory responses. The stress hyperglycemia ratio (SHR) and neu...
Early-life sex hormone deficiency promotes beneficial remodeling in white adipose tissue and whole-body metabolism [0.03%]
生命早期性腺素缺乏促进白色脂肪组织和全身代谢向有益方向重塑
Ignacio Miguel,Ana Alzamendi,Alejandro Ezequiel Harnichar et al.
Ignacio Miguel et al.
Aims: This study investigates the impact of female sex hormone deficiency (FSHD) on white adipose tissue (WAT) development, focusing on two distinct depots: retroperitoneal adipose tissue (RPAT) and inguinal adipose tissu...