Hyperglycemia disrupts alveolar bone homeostasis by inducing stem cell senescence through Mettl3/Foxo3/Sirt1 axis in diabetic periodontitis [0.03%]
高血糖通过Mettl3/Foxo3/Sirt1轴诱导干细胞衰老从而破坏糖尿病牙周炎的肺泡骨稳态
Jie Zhou,Xinyue Li,Lanxi Xiao et al.
Jie Zhou et al.
Aims: Diabetes exacerbates periodontitis by intensifying inflammatory responses and impairing tissue regeneration. Hyperglycemia-induced dysfunction of jawbone-derived bone marrow mesenchymal stem cells (BMSCs) contribute...
Corrigendum to "SNHG8/miR-873-3p/CDK6 axis triggers proliferation and migration of smooth muscle cells in intimal hyperplasia" [Life Sci. 379 (2025) 123878] [0.03%]
“SNHG8/miR-873-3p/CDK6轴触发内膜增生平滑肌细胞的增殖和迁移”一文中关于CDK6的引文更正 [Life Sci. 379 (2025) 123878]
Jiaying Sun,Jing Qi,Jianyao Su et al.
Jiaying Sun et al.
Published Erratum
Life sciences. 2026 Jan 17:124198. DOI:10.1016/j.lfs.2026.124198 2026
Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis [0.03%]
衰老相关GSK3β过度表达通过Nrf2缺乏诱导的肝细胞铁死亡加重肝脏缺血再灌注损伤
You Wu,Yan Zhang,Shiwei Zhang et al.
You Wu et al.
Background and aims: Aging can exacerbate hepatic ischemia-reperfusion injury (HIRI), but the underlying mechanisms remain uncertain. In this study, the mechanisms through which age-related dysregulation of the GSK3β-Nrf...
Galectin-9 in human trophoblast cells: Implications for maternal-fetal immune balance and pregnancy complications [0.03%]
人绒毛膜细胞中半乳糖凝集素-9与母胎免疫平衡及妊娠并发症的关系研究
Xuqing He,Penghao Li,Jingliang Xu et al.
Xuqing He et al.
Introduction: Galectin-9 (Gal-9) is a multifunctional protein belonging to the β-galactoside-binding lectin family playing crucial roles in immune regulation of tumor and pregnancy. However, its roles in placental pathop...
iNKT cell activation exacerbates isoproterenol-induced cardiac injury through macrophage IFN-γ-STAT1 signaling [0.03%]
iNKT细胞活化通过巨噬细胞IFN-γ-STAT1信号加重异丙肾上腺素致心脏损伤
Laiping Zhang,Jie Liu,Xiao Guan et al.
Laiping Zhang et al.
Aims: With the extensive application of immunotherapy in treating cancer, the immunotherapy-related cardiovascular toxicity (ITR-CVT) has gotten a rapid recognition due to its high mortality. Previously, we have found tha...
Single-cell RNA sequencing reveals the role of neutrophils in intestinal ischemia-reperfusion injury in mice [0.03%]
单细胞RNA测序揭示中性粒细胞在小鼠肠缺血再灌注损伤中的作用
Ran Li,Ao Wang,Jiayi Cao et al.
Ran Li et al.
Objective: Intestinal ischemia-reperfusion injury (IRI) severely compromises the mucosal barrier. While neutrophils are key responders, their specific roles and mechanisms remain unclear. This study aims to delineate the ...
From inflammation to innovation: Exploring the emerging roles of itaconate in ARDS [0.03%]
从炎症到创新——探讨ITA在ARDS中的新兴作用机制
Guixiang Yang,Ling Hu,Min Zhong et al.
Guixiang Yang et al.
Acute respiratory distress syndrome (ARDS) is a life-threatening form of respiratory failure characterized by diffuse alveolar damage, pulmonary edema, and decreased lung compliance. It represents the most severe manifestation of acute lung...
Pulmonary neuroendocrine cell as a therapeutic strategy in pulmonary hypertension: Great expectations or Bleak House? [0.03%]
肺神经内分泌细胞作为肺动脉高压治疗策略的选择：充满希望还是前路渺茫？
Yunhua Yang,Yurong Zhang,Shaoxin Gong et al.
Yunhua Yang et al.
Pulmonary hypertension (PH) is a cardiovascular disease with a poor prognosis, mainly attributed to irreversible pulmonary vascular remodeling. Although there are already mature clinical diagnosis and treatment guidelines, the mortality rat...
New insights in the chronic kidney disease-associated osteoarthritis progression: Role of uremic toxin indoxyl sulfate-induced chondrocyte senescence and ferroptosis [0.03%]
慢性肾脏病相关骨关节炎进展的新见解：尿毒症毒素吲哚硫酸盐诱导软骨细胞衰老和铁死亡的作用
Yao-Pang Chung,Ya-Wen Chen,Chun-Fa Huang et al.
Yao-Pang Chung et al.
Aims: Epidemiological data have shown a notably high co-occurrence of osteoarthritis (OA) and chronic kidney disease (CKD). The pathological mechanisms for CKD-associated OA still remain to be clarified. Uremic toxin Indo...
Emodin induces oxidative stress and Ferroptosis in hepatocellular carcinoma cells through the miR-4465/NFE2L3/HMGCR/GPX4 signaling Axis [0.03%]
大黄素通过miR-4465/NFE2L3/HMGCR/GPX4信号轴诱导氧化应激和肝癌细胞的铁死亡
Zhiran Ding,Menghua Zheng,Bingbing Mou et al.
Zhiran Ding et al.
Aims: Emodin, a natural anthraquinone, exerts antitumor effects by increasing reactive oxygen species (ROS) and inducing apoptosis, autophagy, and cell-cycle arrest. However, its potential to induce ferroptosis, a distinc...