Aerobic exercise stabilizes atherosclerotic plaques by suppressing miR-15a-5p-mediated repression of Semaphorin-3A in vascular smooth muscle cells [0.03%]
有氧运动通过抑制血管平滑肌细胞中miR-15a-5p介导的Semaphorin-3A抑制来稳定动脉粥样硬化斑块
Guomin Hu,Weijia Chen,Xiangyuan Zhou et al.
Guomin Hu et al.
Aims: Aerobic exercise reduces cardiovascular events in atherosclerosis, but the causal roles of microRNAs (miRNAs) in mediating exercise-induced vascular smooth muscle cell (VSMC) phenotypic switching and plaque stabiliz...
Targeting the lysine methyltransferase Suv39h1 in cardiac fibroblasts attenuates post-infarct myocardial fibrosis [0.03%]
靶向心房成纤维细胞中的赖氨酸甲基转移酶Suv39h1可减轻梗死后的心肌纤维化
Shuai Liu,Xiaoping Wu,Yujia Xue et al.
Shuai Liu et al.
Aims: Adverse ventricular remodeling following myocardial infarction contributes to heart failure. Following cardiac injury, quiescent fibroblasts trans-differentiate into myofibroblasts and produce extracellular matrix p...
Reversible ubiquitination regulates HSF1 phase separation in response to proteotoxic stress [0.03%]
可逆泛素化调节HSF1在蛋白毒性压力下的相分离现象
Yue Zhu,Jianhua Wang,Shuhong Tang et al.
Yue Zhu et al.
Aims: Heat shock factor 1 (HSF1) undergoes phase separation to form nuclear condensates in response to proteotoxic stress, which governs cell fate. Protein ubiquitination is a widely existed post-translational modificatio...
Role of miR-338-3p and miR-378a-3p as regulators in Crohn's disease pathogenesis: Potential therapeutic implications in inflammatory bowel disease [0.03%]
miR-338-3p和miR-378a-3p在调节克罗恩病发病机制中的作用：在炎症性肠病治疗中的潜在应用意义
Ki-Uk Kim,Jung Min Moon,Eunsu Lim et al.
Ki-Uk Kim et al.
Aims: Epithelial cell-derived microRNAs (miRNAs) are increasingly recognized as contributors to inflammatory bowel disease (IBD) through altered epithelial permeability and inflammatory cytokine production. This prospecti...
Exogenous hydrogen sulphide alleviates diabetes-associated cognitive decline by inhibiting ferroptosis through Nrf2/GPX4 signalling pathway [0.03%]
外源硫化氢通过Nrf2/GPX4信号通路抑制铁死亡从而改善糖尿病相关性认知障碍
Wei Hua,Yilei Sun,Mingze Sun et al.
Wei Hua et al.
Aims: Neuronal ferroptosis affects the pathogenesis of diabetes-associated cognitive decline (DACD). Exogenous hydrogen sulphide (H2S) treatment ameliorates cognitive deficits in diabetic mice. This study aimed to explore...
Amniotic fluid stem cell-derived extracellular vesicles enhance functional recovery of neurogenic bladder and neurovascular plasticity after cerebral ischemia in rats [0.03%]
人羊水干细胞源性外泌体促进脑缺血后神经源性膀胱功能恢复及神经血管重构
Ching-Chung Liang,Steven W Shaw,Hsien-Ming Wu et al.
Ching-Chung Liang et al.
Background: Post-stroke neurogenic bladder dysfunction impairs patients' quality of life, yet current treatments offer limited effectiveness. This study investigated the therapeutic effects and underlying mechanisms of hu...
LEAP2 acts in hepatocytes and at central level, alleviates steatosis and inflammation but resistance in obese and aging [0.03%]
LEAP2作用于肝细胞及中枢水平，可减轻肥胖和衰老小鼠的脂肪变性和炎症但不能改善胰岛素抵抗
Marta V Miguéns,Carmen Quintela-Vilariño,Sabela Casado et al.
Marta V Miguéns et al.
Scope: Global increase in obesity and metabolic syndrome has led to a marked rise in comorbidities, with liver disease emerging as a major concern. Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over...
Endostar overcomes Osimertinib-resistance mediated EGFR-activation mutation, T790M and cis-C797S triple mutations via enhancing the binding of Osimertinib to EGFR protein [0.03%]
エンドースター通过增强奥希替尼与EGFR蛋白的结合克服EGFR激活突变、T790M和顺式C797S三重耐药mutations
Zhongquan Song,Yanmei Zhu,Surong Fang et al.
Zhongquan Song et al.
Aims: The EGFR-C797S mutation is the main cause of Osimertinib resistance. No effective treatment regimen is currently available for patients harboring EGFR-activation mutation/T790M/cis-C797S triple mutations. ...
ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications [0.03%]
ERCC6L通过PLK1介导的有氧糖酵解促进皮肤黑色素瘤进展：机制和治疗意义
Mengdi Zhang,Shengbo Zhou,Bing Han et al.
Mengdi Zhang et al.
Aims: To elucidate the oncogenic role and mechanistic basis of ERCC6L in cutaneous melanoma, focusing on its impact on tumor metabolism and progression. M...
Corrigendum to "Empagliflozin enhances neuroplasticity in rotenone-induced parkinsonism: Role of BDNF, CREB and Npas4" [Life Sci. 312 (1 January 2023) 121258] [0.03%]
“恩格列净增强罗特诺诱导的帕金森病中的神经可塑性：脑源性神经营养因子、CREB 和 Npas4 的作用”一文中存在更正 [生命科学 第312卷（2023年1月）121258]
Hager H Mousa,Maha H Sharawy,Manar A Nader
Hager H Mousa
Published Erratum
Life sciences. 2026 Jan 19:124213. DOI:10.1016/j.lfs.2026.124213 2026