Endothelial NLRP3 inflammasome activation drives immunothrombosis in Streptococcus pyogenes infection [0.03%]
A型链球菌感染中内皮细胞NLRP3炎性小体活化驱动免疫血凝反应
Yi-Hsin Lai,Ya-Hui Liu,Jyun-You Chen et al.
Yi-Hsin Lai et al.
Streptococcus pyogenes (Strep A), a formidable human pathogen, is notorious for causing life-threatening diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome, often complicated by thrombosis and coagulation abnormal...
A protective role of ECSIT in chemotherapy-induced intestinal mucositis by maintaining Lgr5+ intestinal stem cells and gut homeostasis [0.03%]
ECSIT通过维持Lgr5+肠道干细胞和肠平衡在化疗引起的肠黏膜炎中发挥保护作用
Shuai Wang,Yuying Jiang,Jie Yu et al.
Shuai Wang et al.
Aims: Chemotherapy-induced intestinal mucositis (CIM) is a common and severe side effect linked to disrupted intestinal stem cell (ISC) balance, though its molecular regulation remains unclear. The principal objective of ...
STAT1/SLC31A1 signaling promotes diabetic retinopathy progression by mediating cuproptosis-induced M1 polarization in microglial cells [0.03%]
STAT1/SLC31A1信号通路通过介导铜死亡诱导的小胶质细胞M1极化促进糖尿病视网膜病变进展
Jiayang Huang,Qiang Hu,Xue Zhang et al.
Jiayang Huang et al.
One of the main causes of vision impairment in diabetics is diabetic retinopathy (DR). However, the molecular mechanisms controlling its progression remains incompletely known. In this research, we identified the STAT1/SLC31A1 signaling pat...
Enhanced antiproliferative and anti-inflammatory effects of combined metformin, tadalafil, and tamsulosin in a rat model of testosterone-induced benign prostatic hyperplasia [0.03%]
雷公藤红素联合曼陀罗idine通过激活自噬减轻小鼠酒精性肝炎损伤
Samar S Khalaf,Aya M Sherif,Eman T Mehanna et al.
Samar S Khalaf et al.
Aims: Benign prostatic hyperplasia (BPH) is a common condition in aging men, associated with hormonal imbalances, oxidative stress, and inflammation. This study evaluated the effects of metformin, tadalafil, and tamsulosi...
Light exposure-induced circadian rhythm disruption impairs male reproductive health through oxidative stress and apoptosis [0.03%]
光照暴露引起的昼夜节律紊乱通过氧化应激和凋亡损害雄性生殖健康
Guodong Liu,Yuyang Zhang,Hui Gao et al.
Guodong Liu et al.
Aims: Artificial light exposure at night and irregular light schedules are increasingly prevalent environmental stressors in modern society and have been implicated in male reproductive disorders. This study aimed to dete...
The roles of extrachromosomal DNA in tumorigenesis and therapeutic resistance in cancer [0.03%]
细胞外染色体DNA在肿瘤发生和发展耐药中的作用
Yidan Zhang,Jiale Li,Hongbin Wang et al.
Yidan Zhang et al.
Extrachromosomal DNA (ecDNA) is a form of circular DNA that exists independently of chromosomes. Predominantly observed in tumor cells, ecDNA represents a key manifestation of genomic instability in cancer. In contrast to chromosomal DNA, e...
Developmental cardiovascular disruption triggered by polystyrene nanoplastics in zebrafish mediated through oxidative stress [0.03%]
聚苯乙烯纳米塑料通过氧化应激介导引发斑马鱼发育期心血管紊乱
Febriyansyah Saputra,Yu-Tzu Tsao,Agoes Soegianto et al.
Febriyansyah Saputra et al.
The rising prevalence of polystyrene nanoplastics (PSNPs) in aquatic ecosystems poses not only ecological threats but also growing concerns for human health, particularly through their potential to interfere with cardiovascular development ...
Phosphodiesterase 3 inhibition mitigates sepsis progression in a rodent sepsis model [0.03%]
磷二酯酶3抑制减轻啮齿动物脓毒症模型中的脓毒症进展
Junior Garcia Oliveira,Gustavo Ferreira Alves,Elaine Leocádia Anton et al.
Junior Garcia Oliveira et al.
Background: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, disrupts intracellular messengers, such as cyclic nucleotides cAMP and cGMP, contributing to high mortal...
Piezo-mediated mechanically activated currents in organ fibrosis: Novel mechanisms and therapeutic strategies [0.03%]
器官纤维化中的压电介导机械激活电流：新机制和治疗策略
Ling Dong,Li-Chan Lin,Sui Mao et al.
Ling Dong et al.
Organ fibrosis is one of the major challenges to global health. During the process of fibrosis, the abnormal accumulation of extracellular matrix (ECM) leads to changes in the mechanical microenvironment of tissues. The organ system is a hi...
Viable exogenous mitochondria modulate neurochemical and behavioral features of fibromyalgia in a reserpine-induced fibromyalgia model [0.03%]
可行的外源线粒体调节血清素耗竭诱导的纤维肌痛模型中小鼠的行为和神经化学特征
Nourhan S Elkholy,Haitham S Mohammed,Ayman Saber Mohamed et al.
Nourhan S Elkholy et al.
Fibromyalgia Syndrome (FMS) is a chronic disorder marked by widespread pain, fatigue, and cognitive dysfunction, often associated with mitochondrial dysfunction and oxidative stress. Despite existing treatments, none address the underlying ...