Macrophages, fibrosis, and intrauterine adhesions: Cellular interactions and pathophysiological implications [0.03%]
巨噬细胞、纤维化和宫腔粘连：细胞相互作用与病理生理意义
Xingyu Jia,Yunfei Zhang,Huihua Cai
Xingyu Jia
Intrauterine Adhesion (IUA) is a pathological condition caused by damage to the basal layer of the endometrium, often triggered by uterine surgeries such as curettage or intrauterine infections. It is primarily characterized that the normal...
Estrogen receptors α/β exhibit distinct intermolecular interactions to mediate gene regulatory events [0.03%]
雌激素受体α/β通过不同的分子间相互作用介导基因调控事件
Ayushi Chhabra,Sheeba Rizvi,Sudhir Kumar et al.
Ayushi Chhabra et al.
Aim: Estrogen receptors (ERα and ERβ) are intracellular transcription factors that regulate gene expression when bound by estrogens. Although their roles in cellular functions and the onset of disease are relatively wel...
Dose-dependent effects of vildagliptin (DPP-4 inhibitor) in a scopolamine-induced memory impairment model in rats [0.03%]
在山梗菜碱诱导的大鼠记忆损害模型中，维格列汀（DPP-4抑制剂）的剂量依赖性效应
Fazilet Sen Metin,Elif Aksoz
Fazilet Sen Metin
Aims: Cognitive decline and dementia are closely linked with metabolic disorders such as type 2 diabetes mellitus, sharing common pathophysiological mechanisms including insulin resistance, inflammation, and oxidative str...
Exercise alleviates the obesity-related dysfunction of skeletal muscle and heart caused by Akh gene knockdown in Drosophila [0.03%]
运动能够缓解Drosophila中Akh基因敲低引起的肥胖相关的骨骼肌和心脏功能障碍
Ying Lin,Deng-Tai Wen,Qing-Yao Sun et al.
Ying Lin et al.
The Adipokinetic hormone (Akh), a functional analog of mammalian glucagon, plays a key role in regulating energy metabolism in Drosophila. Although exercise is recognized as an important intervention for preventing and alleviating obesity-r...
Leap2 modulates β-adrenergic triggered cardiac responses and provokes antihypertensive effects [0.03%]
Leap2调节β肾上腺素能触发的心脏反应并产生降压效果
Sixta Isabel Atencio Berrio,Jhulle Horrane Carvalho,João Batista Dutra et al.
Sixta Isabel Atencio Berrio et al.
Receptors for orexigenic hormones are broadly expressed in different tissues. Growth hormone secretagogue receptor (GHSR) is the receptor for the gastric peptide hormone ghrelin, although it further displays an intrinsic ligand-independent ...
High-intensity interval training attenuates the progression of diastolic and skeletal muscle dysfunction in the two-hit mouse model of HFpEF [0.03%]
高强度间歇训练可减轻双打击小鼠HFpEF模型的舒张性和骨骼肌功能障碍进展
Francisco Pino-De la Fuente,Mayarling F Troncoso,Sebastián Urquiza-Zurich et al.
Francisco Pino-De la Fuente et al.
Background: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial syndrome characterized by diastolic dysfunction, metabolic disturbances, and skeletal muscle impairments. Exercise training has been r...
HHcy promotes hypertension by activating ferroptosis via suppression of the renal H₂S-SLC7A11/GPX4 axis [0.03%]
HHcy通过抑制肾脏H2S-SLC7A11/GPX4轴激活铁死亡从而促进高血压
Pan Huang,Kexin Zhang,Ying Chen et al.
Pan Huang et al.
Elevated homocysteine (Hcy) is an independent risk factor for hypertension, and kidney is an important organ for Hcy metabolism and blood pressure regulation, and its damage is closely related to the process of hypertension. Recent evidence...
Loss of Galectin-3 in the epidermis exacerbates psoriasis pathogenesis via inhibiting autophagy [0.03%]
皮肤糖类丰富蛋白-3丢失通过抑制自噬加重银屑病病理学表現
Shanshan Han,Meiqi Cheng,Shengtao Jiang et al.
Shanshan Han et al.
Aims: Galectin-3 (Gal3) is linked to psoriasis pathophysiology, however, the detailed mechanism of Gal3 involved in this course still needs further addressing. This study aimed to elucidate the role of Gal3 in psoriasis. ...
Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression [0.03%]
乳酸通过激活H3K18乳酰化依赖的HSPA6上调促进急性肾损伤中的铜死亡现象
Mingxing Sui,Jiazhao Fu,Yuhong Li et al.
Mingxing Sui et al.
Aims: The present study aims to investigate the role and mechanism of lactate-induced histone lactylation in regulating cuproptosis during renal IRI. Mate...
Gestational sevoflurane exposure induces amino acid metabolic reprogramming and cognitive deficits in offspring [0.03%]
妊娠期吸入七氟烷可诱导后代氨基酸代谢重构和认知缺陷
Jieyu Ma,Li Xu,Nai Sun et al.
Jieyu Ma et al.
Background: Sevoflurane is one of the most widely used anesthetics in pediatric medicine; however, accumulating evidence raises critical concerns regarding its potential to induce long-term neurodevelopmental deficits. De...