Hinokiflavone exerts dual regulation on apoptosis and pyroptosis via the SIX4/Stat3/Akt pathway to alleviate APAP-induced liver injury [0.03%]
hinokiflavone通过SIX4/Stat3/Akt信号途径对凋亡和炎性坏死的双向调节缓解APAP诱导的肝损伤
Yi-Ying Liu,Yang Zhang,Guan-Yue Shan et al.
Yi-Ying Liu et al.
Hinokiflavone (HF), classified as a flavonoid, is a main bioactive compound in Platycladus orientalis and Selaginella. HF exhibits activities including anti-HIV, anti-inflammatory, antiviral, antioxidant and anti-tumor effects. The study ai...
Short-chain fatty acid on blood-brain barrier and glial function in ischemic stroke [0.03%]
短链脂肪酸对缺血性脑卒中后的血脑屏障及胶质细胞功能的影响
Khiany Mathias,Richard Simon Machado,Solange Stork et al.
Khiany Mathias et al.
Stroke is the second most common cause of death and one of the most common causes of disability worldwide. The intestine is home to several microorganisms that fulfill essential functions for the natural and physiological functioning of the...
P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity [0.03%]
自噬的P62介导的降解SLC7A11调节多柔比星诱导的心脏毒性铁死亡路径
Jihong Wang,Hong Yi,Juxiang Li et al.
Jihong Wang et al.
Doxorubicin-induced cardiotoxicity (DIC) poses a significant challenge, impeding its widespread application. Emerging evidence suggests the involvement of ferroptosis in the DIC. While the downregulation of SLC7A11 expression has been linke...
Maternal low-dose caffeine intake during the perinatal period promotes short- and long-term sex-dependent hormonal and behavior changes in the offspring [0.03%]
围产期母亲低剂量摄入咖啡因会促进子代短期和长期的性别依赖性激素和行为变化
Luana Lopes de Souza,Lilian Guedes Meyer,Camila Lüdke Rossetti et al.
Luana Lopes de Souza et al.
Aim: Maternal caffeine crosses the placenta and mammary barriers, reaching the baby and, because his/her caffeine metabolism is immature, our hypothesis is that even a low caffeine intake (250 mg/day), lower than the dose...
Generation of mouse testicular organoids with highly compartmentalized tubular lumen structure and their cryopreservation [0.03%]
具有高度分化的管腔结构小鼠睾丸类器官的构建及其冻存复苏
Jia Tan,Jiahui Li,Chunyan Lin et al.
Jia Tan et al.
Testicular organoids have great potential for maintaining male fertility and even restoring male infertility. However, existing studies on generating organoids with testis-specific structure and function are scarce and come with many limita...
Androgen deprivation exacerbates AD pathology by promoting the loss of microglia in an age-dependent manner [0.03%]
雄激素剥夺通过促进小胶质细胞的年龄依赖性丧失加剧AD病理变化
Jiaxin Cao,Haichao Chen,Yishu Zhang et al.
Jiaxin Cao et al.
Aims: Microglial cells are integral to the pathogenesis of Alzheimer's disease (AD). The observed sex disparity in AD prevalence, with a notable predominance in women, implies a potential influence of sex hormones, such a...
W Michael Brode,Esther Melamed
W Michael Brode
Long COVID is a complex, multisystem illness with a poorly understood pathophysiology, absence of specific diagnostic tests or criteria, or evidence-based treatments. With over 200 identified symptoms and approximately 10% of COVID-19 cases...
Rapid liver self-recovery: A challenge for rat models of tissue damage [0.03%]
快速肝自我恢复：组织损伤大鼠模型面临的挑战
Argelia Calvillo-Robledo,Samson-Soleil,Bruno A Marichal-Cancino et al.
Argelia Calvillo-Robledo et al.
Animal models, mainly murine, stay as a fundamental resource in diverse research pursuits, notably contributing to significant strides in discovering novel treatments for therapeutic applications. Preclinical assays must consider the existe...
ERP29 regulates the proliferation of endometrial carcinoma via M6A modification [0.03%]
通过M6A修饰调控子宫内膜癌增殖的ERP29的作用
Yanqi Ying,Jingyan Zhang,Dan Ren et al.
Yanqi Ying et al.
Aims: Endoplasmic reticulum protein 29 (ERP29) is crucial for endoplasmic reticulum stress (ERS). M6A plays an important role in the progression of endometrial cancer (EC). The study investigated the role of ERS-related g...
Regulation of TGF-β/BMP signaling during osteoblast development by non-coding RNAs: Potential therapeutic applications [0.03%]
非编码RNA在调控骨细胞发育中TGF-β/BMP信号通路的潜在治疗应用
Iyyappan Saranya,Nagarajan Selvamurugan
Iyyappan Saranya
Bone is a connective tissue that is metabolically active and serves multiple functions, including movement, structural support, and organ protection. It is comprised primarily of three types of bone cells, namely osteoblasts, osteocytes, an...